Pilot Project Abstract - Purnell, Jonathan, MD

Purnell, Jonathan, MD, Associate Professor, Dept. of Endocrinology, OHSU

“Disordered lipid and glucose metabolism in the non-human primate model of diabetes”

Disordered regulation of fatty acid metabolism has emerged as a key link between inflammation, insulin resistance, dyslipidemia, non-alcoholic steatoheptitis, and abnormal weight regulation leading to obesity. High-fat diets promote weight gain and excess deposition of lipids in the liver and muscle, cause dyslipidemia, and impair insulin signaling. Using a novel nonhuman primate (NHP) model of diabetes, the studies proposed here will bring together researchers from OHSU, the Advance Imaging Research Center (AIRC), and the Oregon National Primate Research Center (ONPRC) to use in-vivo imaging and glucose clamp techniques that will provide detailed analysis of the role of disordered lipid metabolism in the expression of insulin resistance in liver and muscle in this model.