Pilot Project Abstract - Davis, Harry B., PhD

Davis, Harry B., PhD, Postdoctoral Fellow, Dept. of Biomaterials and Biomechanics, OHSU

“Preparation and confirmation of the bioactive characteristics of silicate-based glasses for the repair and reconstruction of damaged tooth and bone tissue”

Silicate-based bioactive glasses (BAGs) have been in use for over 30 years; they act as scaffolds upon which growth of bioorganic materials can occur, have very low rejection potential by the immune system, carry no risk of viral or bacterial infection, act as a reservoir for ions necessary for the formation of new bioinorganic materials, are easily prepared, and have long shelf-lives. These have shown a remarkable ability to effect the formation of new apatite, Ca10(PO4)6(OH)2, that is necessary for repairing damaged tooth and bone tissue. We propose to make new BAGss that, when used in dental composites, will enhance the formation of new tooth and bone tissue. We will prepare new silicate-based glasses containing Ca, P, F, and B by a metalorganic sol-gel route which involves the homogeneous combination of tetraethyl orthosilicate (TEOS), triethyl phosphate (TEP), calcium methoxyethoxide ((CMOE) and boron trifluoride diethyl etherate (BF3•OEt2). Bioactivity of the resultant BAGs will be confirmed by the observation of apatite formation and ion release profiles upon exposure to simulated body fluid (SBF). Beyond the scope of the initial project, the new BAGs will ultimately be tested in orthodontic applications to see if they help prevent decalcification around spots where brackets are bonded to the tooth, and to determine if they are better able to block dentin tubules for the purpose of preventing tooth sensitivity. These BAGs might also be useful as coatings for implant materials in order to prevent rejection and to enhance bone repair and regeneration.