Michiko Nakano

Michiko Nakano

Research Professor
Institute of Environmental Health; Division of Environmental and Biomolecular Systems
Office: Hatfield Research Center, 3rd floor, Room 355
Phone: 503-346-3430


Ph. D., Cell Biology, University of Tokyo, 1976



  • Mitsubishi-Kasei Institute of Life Science, Postdoctoral Fellow 1977-78
  • Meiji College of Pharmacy, Tokyo, Assistant Professor, 1978-82
    Associate Professor, 1982-87
  • Oklahoma State University, Research Associate, 1987-88
  • Louisiana State University Medical Center at Shreveport, Research Associate, 1988-1995
    Research Assistant Professor, 1995-1998
  • OGI School of Science and Engineering, Research Assistant Professor, 1998-2000


Research Interests

Anaerobiosis of Bacillus subtilis; oxygen-controlled gene regulation; two-component signal transduction system; transcriptional activation; nitrate/nitrite reductases; flavohemoglobin; anaerobic electron transport; nitric oxide signaling.


Selected Publications

Amrita Lama; Jan Pané-Farré; Tai Chon; Anna M. Wiersma; Clarissa S. Sit; John C. Vederas; Michael Hecker; Michiko M. Nakano
Response of methicillin-resistant Staphylococcus aureus to amicoumacin a
PLoS ONE. 2012;7(3):[e34037].

Sushma Kommineni; Amrita Lama; Benjamin Popescu; Michiko M. Nakano
Global transcriptional control by NsrR in Bacillus subtilis
Journal of Bacteriology. 2012;194(7):1679-1688.

Erik T. Yukl; Alexandra Ioanoviciu; Santhosh Sivaramakrishnan; Michiko M. Nakano; Paul R. Ortiz De Montellano; Pierre Moënne-Loccoz
Nitric oxide dioxygenation reaction in devS and the initial response to nitric oxide in mycobacterium tuberculosis
Biochemistry. 2011;50(6):1023-1028.

Gnana S. Siluvai; Michiko Nakano; Mary Mayfield; Ninian J. Blackburn
The essential role of the Cu(II) state of Sco in the maturation of the CuA center of cytochrome oxidase: Evidence from H135Met and H135SeM variants of the Bacillus subtilis Sco
Journal of Biological Inorganic Chemistry. 2011;16(2):285-297.

Peter Zuber; Shefali Chauhan; Praseeda Pilaka; Michiko M. Nakano; Sairam Gurumoorthy; Ann A. Lin; Skye M. Barendt; Bui Khanh Chi; Haike Antelmann; Ulrike Mäder
Phenotype enhancement screen of a regulatory Spx mutant unveils a role for the ytpQ gene in the control of Iron homeostasis
PLoS ONE. 2011;6(9):[e25066].

Michiko M. Nakano; Ann Lin; Cole S. Zuber; Kate J. Newberry; Richard G. Brennan; Peter Zuber
Promoter recognition by a complex of Spx and the C-terminal domain of the RNA polymerase α subunit
PLoS ONE. 2010;5(1).

Sushma Kommineni; Erik Yukl; Takahiro Hayashi; Jacob Delepine; Hao Geng; Pierre Moënne-Loccoz; Michiko Nakano M.
Nitric oxide-sensitive and -insensitive interaction of Bacillus subtilis NsrR with a ResDE-controlled promoter
Molecular Microbiology. 2010;78(5):1280-1293.

Tai Huang; Hao Geng; Venugopal R. Miyyapuram; Clarissa S. Sit; John C. Vederas; Michiko M. Nakano
Isolation of a variant of subtilosin A with hemolytic activity
Journal of Bacteriology. 2009;191(18):5690-5696.

Gnana S. Siluvai; Michiko M. Nakano; Mary Mayfield; Mark J. Nilges; Ninian J. Blackburn
H135A controls the redox activity of the Sco copper center. Kinetic and spectroscopic studies of the His135Ala variant of Bacillus subtilis Sco
Biochemistry. 2009;48(51):12133-12144.

Erik T. Yukl; Alexandra Ioanoviciu; Michiko M. Nakano; Paul R. Ortiz De Montellano; Pierre Moënne-Loccoz
A distal tyrosine residue is required for ligand discrimination in DevS from Mycobacterium tuberculosis
Biochemistry. 2008;47(47):12532-12539.

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