James Whittaker

James Whittaker

Associate Professor
Institute of Environmental Health; Division of Environmental and Biomolecular Systems
Office: Richard Jones Hall, Room RJH 6379
Phone: 503-346-3436
Lab: 503-346-3435


Ph.D. Biochemistry, University of Minnesota, 1983
B.Sc. (Hon.), Biological Sciences, Sir George Williams University, Montreal, 1978



  • NIH Postdoctoral Fellow, Chemistry, Stanford University, 1983-1986
  • Carnegie Mellon University, Assistant Professor, Chemistry 1983-1986, Associate Professor, Chemistry, 1992-1996


Research Interests

Electronic structures and dynamics of metalloenzyme active sites; spectroscopic and computational approaches to biomolecular structure; metalloenzyme mechanisms; enzyme engineering; biology of metal ions.


Selected Publications

Mei M. Whittaker; James W. Whittaker
Expression and purification of recombinant Saccharomyces cerevisiae mitochondrial carrier protein YGR257Cp (Mtm1p)
Protein Expression and Purification. 2014;93:77-86.

James W. Whittaker
Cell-free protein synthesis: The state of the art
Biotechnology Letters. 2013;35(2):143-152.

Mei M. Whittaker; James W. Whittaker
Metallation state of human manganese superoxide dismutase expressed in Saccharomyces cerevisiae
Archives of Biochemistry and Biophysics. 2012;523(2):191-197.

Iain L. McConnell; Vladimir M. Grigoryants; Charles P. Scholes; William K. Myers; Ping-Yu Chen; James W. Whittaker; Gary W. Brudvig
EPR-ENDOR characterization of ( 17O, 1H, 2H) water in manganese catalase and its relevance to the oxygen-evolving complex of photosystem II
Journal of the American Chemical Society. 2012;134(3):1504-1512.

James W. Whittaker
Non-heme manganese catalase - The 'other' catalase
Archives of Biochemistry and Biophysics. 2012;525(2):111-120.

Mei M. Whittaker; Thomas F. Lerch; Olga Kirillova; Michael S. Chapman; James W. Whittaker
Subunit dissociation and metal binding by Escherichia coli apo-manganese superoxide dismutase
Archives of Biochemistry and Biophysics. 2011;505(2):213-225.

James W. Whittaker
Metal uptake by manganese superoxide dismutase
Biochimica et Biophysica Acta - Proteins and Proteomics. 2010;1804(2):298-307.

Ellis S. Kempner; James W. Whittaker; Jay H. Miller
Radiation inactivation of galactose oxidase, a monomeric enzyme with a stable free radical
Protein Science. 2010;19(2):236-241.

Troy A. Stich; James W. Whittaker; R. David Britt
Multifrequency EPR studies of manganese catalases provide a complete description of proteinaceous nitrogen coordination
Journal of Physical Chemistry B. 2010;114(45):14178-14188.

Zhiguo Li; Allison Moy; Kirti Sohal; Carolyn Dam; Peter Kuo; James Whittaker; Mei Whittaker; Nejat Düzgünes; Krystyna Konopka; Andreas H. Franz; et al.
Expression and characterization of recombinant human secretory leukocyte protease inhibitor (SLPI) protein from Pichia pastoris
Protein Expression and Purification. 2009;67(2):175-181.

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