Implant-related Bleeding Study

We are excited to announce a clinical research study for women using the contraceptive implant (Nexaplanon or Implanon) who are experiencing frequent or persistent bleeding.

Why is this study being done?Edelman Tamoxifen study photo

There are currently no medications approved to treat vaginal bleeding in women using the contraceptive implant. The study drug may reduce bleeding when taken for only a few days per month.

The purpose of this study is:

The purpose of this study is to learn whether a medication called tamoxifen might help to stop or reduce vaginal bleeding in women who use the contraception implant (Implanon or Nexplanon). You may take the study drug or placebo for up to six months. Participation in the study will last 6-7 months and requires up to 8 visits to OHSU.


  • Women between the ages of 15 and 45 who are current Nexplanon or Implanon users
  • Have frequent or persistent bleeding while using the implant
  • Have a cell phone that is capable of receiving text or e-mail messages
  • In general good health


  • Study related physical and gynecologic exams
  • Investigational study medication and/or placebo
  • Up to $400 compensation for time and travel over the course of the study 

Who do I contact for additional information?

To find out more information and to learn if you are qualified to participate, fill out the online form or call the Women’s Health Research Unit confidential recruitment line.

Complete the Online Form or call 503-494-3666, or email