About our center
The Marshall Center, led by Lynn Marshall, Sc.D., conducts epidemiologic and clinical research on musculoskeletal conditions. Dr. Marshall’s research is informs public health and clinical practice by identifying risk factors for musculoskeletal conditions. This information can used to improve our ability to identify and intervene on high risk groups. Dr. Marshall has extensive training in statistical methods and brings a strong quantitative focus to her research. She actively collaborates with many health professionals, including biostatisticians, molecular biologists, surgeons, physiatrists, and physical therapists, both within and outside of OHSU. In addition to her scholarly activities, Dr. Marshall contributes to the teaching and service missions of OHSU as well. She is a research advisor and mentor to OHSU medical students, Orthopaedic residents, and graduate students. She serves as a vice chair of the Institutional Review Board (IRB).
• Low back pain, orthopaedic spine conditions associated with low back pain, and their long outcomes in older adults
• Risk factors for accidental falls and for bone fractures in older women and men
• Factors associated with bone loss and changes in physical functioning during aging
• Outcomes associated with lower urinary tract symptoms severity in older men
• Measurement of biologic phenomena, including assays and body composition imaging. The Marshall Center is collaborative, involving not only epidemiologic methods and statistical analysis but also disciplines that guide investigation of biologic mechanisms and clinical relevance.
Current active grants
Gerlinger Trust Research Award (Marshall, PI)
Spinal canal dimensions and pain symptoms of degenerative lumbar stenosis in older men
Co-investigators: Dr. Hans Carlson, Dr. Nels Carlson, and Dr. Jayme Hiratzka.
Watson Laboratories, Inc (Marshall, Co-PI)
Are lower urinary tract symptoms (LUTS) associated with an increased risk of fractures in elderly men?
Co-PI: Dr. J. Kellogg Parsons at University of California, San Diego
Co-investigator: Dr. Jodi Lapidus at OHSU.
Shriners Hospital for Children (Sakai, PI)
Development of a blood test for marfan syndrome
Selected publications (from 66 total)
1. Denard PJ, Holton KF, Miller J, Fink HA, Kado DM, Marshall LM, Yoo JU. Back pain, neurogenic symptoms and physical function in relation to spondylolisthesis among elderly men. Spine J 2010; 10: 865-873.
2. Holton KF, Denard PJ, Yoo JU, Kado DM, Barrett-Connor E, Marshall LM. Diffuse idiopathic skeletal hyperostosis (DISH) and its relation to back pain among older men: The MrOS Study. Semin Arthritis Rheum 2011; 41: 131-138.
3. Katzman WB, Miller-Martinez D, Marshall LM, Lane NE, Kado DM. Kyphosis and paraspinal muscle composition in older men: a cross-sectional study for the Osteoporotic Fractures in Men (MrOS) Research Group. BMC Musculoskelet Disord 2014; 15:19 doi:10.1186/1471-2474-15-19
4. Marshall LM,* Holton KF,* Parsons JK,* Lapidus JA,* Ramsey K, Barrett-Connor E. Lifestyle and health factors associated with progressing and remitting trajectories of untreated lower urinary tract symptoms among elderly men. Prostate Cancer Prostatic Dis 2014; 17:265-272. * Equal contributions.
5. Marshall LM*, Carlson E*, O'Malley JP, Snyder CK, Charbonneau N, Hayflick S, Coselli JS, Lemaire SA, Sakai LY. Thoracic aortic aneurysm frequency and dissection are associated with fibrillin-1 fragment concentrations in circulation. Circ Res. 2013; 113:1159-1168. * Equal contributions.
6. Hart RA, Marshall LM, Hiratzka SL, Kane MS, Volpi J, Hiratzka JR. Functional limitations due to stiffness as a collateral impact of instrumented arthrodesis of the lumbar spine. Spine 2014, in press.