Clinical Trials

The Harold Schnitzer Diabetes Health Center Research Department is committed to promoting and conducting excellent clinical research. Our goal is to enhance the quality of life of those living with or affected by diabetes.

Our efforts to find a cure for diabetes, and to improve life for people with this condition, are made possible by volunteers who participate in research studies. When you volunteer, you help us answer important questions about diabetes.

If you would like to be considered to participate in any of our research studies below, please call 503 494-4704, complete our Online Application Form for more information.

The Sanford Project: T-Rex Study 

Study started on: 12/13/16

Currently recruiting patients for this study? Yes

The Sanford Project: T-Rex Study is investigating the safety and effectiveness of a treatment using one's own blood to change the course of their type 1 diabetes. This study is seeking to preserve insulin-making cells to lessen the impact of the disease in adolescents with type 1 diabetes. 

You may qualify to participate if you:  

  • Are between 8 and 18 years of age 
  • Were diagnosed with type 1 diabetes in the last 100 days 

What is involved?:  

  • 12 visits to OHSU with some lasting up to 6 hours
  • Laboratory tests including one large blood draw
  • One time infusion of your own cells
To learn more about having your child participate in this study contact: Rebecca Fitch email: or call: 503-494-4739.

eIRB #16177


TrialNet Study

TrialNet - Pathway to Prevention

Study started on: 2/13/2009

Currently recruiting patients for this study? Yes

Principal Investigator is Andrew Ahmann, M.D.

The purpose of this study is to learn more about how type 1 diabetes develops in "at-risk" individuals. At-risk individuals are those that have a blood relative with type 1 diabetes.

Who is eligible to be screened?

•  Anyone 1-45 years old with a parent, child, brother or sister with type 1 diabetes.

•  Anyone 1-20 years old with a niece, nephew, aunt, uncle, grandparent, half-brother, half-sister, or cousin with type 1 diabetes.

To learn more about participating in this study contact: Don DeFrang email: or call: 503-494-4704

eIRB #5023


Evaluating the dynamics of insulin and non-insulin mediated effects on glucose during aerobic exercise in subjects with type 1 diabetes.

Currently recruiting patients for this study? Yes

Study started on: 6/16/2017

Principal Investigators: Joseph El Youssef, MD MCR and Peter Jacobs PhD

Co-Investigators: Jessica Castle, MD

Kathy Hanavan RN MSN ANP-BC

Leah Wilson MD

You may qualify to participate if you:

  • Between ages 18 and 45
  • Diagnosed with type 1 diabetes for at least 1 year
  • Physically able to perform exercise for 45 minutes
  • Have a hemoglobin A1c less than 10%

What is involved?:  

  • 2-hour screening visit
  • 10-hour study visits with 45 minutes of aerobic exercise during each visit
  • 3 short follow-up phone calls after each study visit

Is compensation provided?:

$150 for each of three visits for a maximum of $450.

To learn more about participating in this study contact: Debbie Branigan 503-418-9070  




en español

Study started on: 5/17/13

Currently recruiting patients for this study? No

Principal Investigator is Andrew Ahmann, M.D.

The National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health, in collaboration with 37 medical clinics, including Oregon Health & Science University, is conducting the GRADE Study (The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study). GRADE is a clinical trial designed for people living with diabetes.  The goal of the study is to find the best combination drug treatment for diabetes.

You may qualify for this study, if you:

  • Have had type 2 diabetes for less than 10 years
  • Are taking metformin as your only diabetes medication 

If you join GRADE, you will:

  • Come to Oregon Health & Science University for four diabetes medical visits each year for up to 7  years
  • Take metformin plus one of 4 other diabetes medications chosen by chance
  • Receive diabetes treatment, FDA approved medicines and supplies at no cost to you
  • Receive physical exams and lab tests at no cost to you
  • Receive $100 at the end of each year as well as $10 per visit 
The GRADE Study is being conducted at Oregon Health & Science University. 

eIRB #9157