Clinical Trials

The Harold Schnitzer Diabetes Health Center Research Department is committed to promoting and conducting excellent clinical research. Our goal is to enhance the quality of life of those living with or affected by diabetes.

Our efforts to find a cure for diabetes, and to improve life for people with this condition, are made possible by volunteers who participate in research studies. When you volunteer, you help us answer important questions about diabetes.

If you would like to be considered to participate in any of our research studies below, please call 503 494-4704, complete our Online Application Form for more information.

 

GRADE Study

Study started on: 5/17/13

Currently recruiting patients for this study? Yes

Principal Investigator is Andrew Ahmann, M.D.

View the Study Brochure

The National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health, in collaboration with 37 medical clinics, including Oregon Health & Science University, is conducting the GRADE Study (The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study). GRADE is a clinical trial designed for people living with diabetes.  The goal of the study is to find the best combination drug treatment for diabetes.

You may qualify for this study, if you:

  • Have had type 2 diabetes for less than 10 years
  • Are taking metformin as your only diabetes medication 

If you join GRADE, you will:

  • Come to Oregon Health & Science University for four diabetes medical visits each year for up to 7  years
  • Take metformin plus one of 4 other diabetes medications chosen by chance
  • Receive diabetes treatment, FDA approved medicines and supplies at no cost to you
  • Receive physical exams and lab tests at no cost to you
  • Receive $100 at the end of each year as well as $10 per visit 
The GRADE Study is being conducted at Oregon Health & Science University.  To learn more about participating in this study, contact: 503 494-4650.

eIRB #9157

Four Way Crossover Closed Loop with Exercise Detection

Study Started on: 8/19/2016

Currently recruiting patients for this study? Yes

Principal Investigators Jessica Castle, M.D. and Peter Jacobs, Ph.D.

You may qualify to participate if you:

  • Between the age of 21 to 45
  • Have type 1 diabetes
  • Currently use an insulin pump
  • Physically able to perform 45 minutes of exercise
The purpose of this study is to determine whether a dual hormone artificial pancreas with an exercise detection algorithm outperforms both single hormone artificial pancreas and a low glucose suspend algorithm and current care using the subject's own insulin pump. This system can detect exercise.This automated system involves the use of a glucose sensor and a computer program to determine an insulin or glucagon infusion rate every 5 minutes. The study requires a 2 hour screening visit, a 2 hour pump and sensor training visit and four 84 hour exercise study visits. For the 84 hour visits, Day 1 and Day 4 are 12 hour inpatient visits conducted at the research center at OHSU where study participants will exercise for 45 minutes. Study participants will be compensated up to $900 for participation.

The study is being conducted at Oregon Health & Science University. To learn more about participating in this study contact: Debbie Branigan (503) 418-9070

eIRB #15590

TrialNet Study

TrialNet - Pathway to Prevention

Study started on: 2/13/2009

Currently recruiting patients for this study? Yes

Principal Investigator is Andrew Ahmann, M.D.

The purpose of this study is to learn more about how type 1 diabetes develops in "at-risk" individuals. At risk individuals are those that have a blood relative with type 1 diabetes.

eIRB #5023