OHSU

Cancer Biology

Scientific Goals

The goal of this program is to discover and develop new molecular mechanisms that control growth, differentiation, survival, clonal adaptation and genetic stability in normal mammalian cells and to define perturbations of these mechanisms that are necessary and sufficient for the development of cancer.

Members of this group share the overarching principle of the OHSU Knight Cancer Institute to develop novel and less toxic forms of treatment and prevention of malignant diseases. Toward this goal, we must first develop a comprehensive and integrated picture of molecular pathogenesis, a picture that necessarily requires studies of normal, pre-malignant and malignant cells. Members use advanced tools of genetic, cellular and molecular biology to identify interactions between cancer cells and their microenvironment, identify molecular targets for treatment and prevention and identify control points for terminal differentiation, cell cycle arrest, genome protection and apoptosis.

Focus Groups

The Cancer Biology program constitutes the foundation of basic science research of the OHSU Knight Cancer Institute. There are three research focus areas designed to help facilitate collaborative interactions: Signal Transduction, Carcinogenesis/Genetic Instability and Apoptosis. Members fall into one or more of these groups.

  1. Signal Transduction members focus their research on cellular signaling pathways and mechanisms of relevance to the regulation of normal and cancer cell growth including the integrated function of growth factors and their receptors, kinase-mediated signaling phenomena and the regulation of transcription that lies downstream of the aforementioned events.
  2. Carcinogenesis/Genetic Instability members focus their studies on cell cycle check-point control, DNA damage and repair pathways, and the relationship of these events to the development of genetic instability and cancer.
  3. Apoptosis members focus their research on molecular mechanisms that regulate programmed cell death and how this impacts the development of cancer and its role in cancer therapy.

Program Leaders

Mathew Thayer, Ph.D.

Rosalie Sears, Ph.D.



Program Members

Researcher Research Area

Carbone, Lucia, Ph.D.

Appointments:
Behavioral Neurocience  

Coussens, Lisa, Ph.D.

Appointments:
Department Chair, Department of Cell and Developmental Biology, OHSU Director of Basic Research, OHSU Knight Cancer Research  

Dai, Mushui, M.D., Ph.D.

Lab Page

Special Expertise:
  • p53
  • MDM2
  • c-Myc
  • ribosomal protein
  • nucleolar stress
 

David, Larry, Ph.D.

Special Interest:
 

Enns, Caroline, Ph.D

Appointments:
Professor, Cell and Developmental Biology  

Forte, Michael, Ph.D.

Lab Page

Special Expertise:
  • Drosophila
  • Mitochondria
  • Calcium
  • Permeability transition Pore
  • Signaling
 

Goodman, Richard, M.D., Ph.D.

Lab Page

Appointments:
Director, Vollum Institute Professor of Cell and Developmental Biology Professor of Biochemistry Professor of Molecular Biology  

Gray, Joe, Ph.D.

Lab Page

Appointments:
Gordon Moore Endowed Chair Chair, Department of Biomedical Engineering Director, OHSU Center for Spatial Systems Biomedicine Associate Director for Translational Research, OHSU Knight Cancer Institute  

Grompe, Markus, M.D.

Lab Page

Special Expertise:
  • Fonconi
  • metabolism
 

Harrington, Christina, Ph.D.

Appointments:
Director, Affymetrix Microarray Core  

Impey, Soren, Ph.D.

Lab Page

Appointments:
Assistant Professor
 

Iordanov, Mihail, Ph.D.

Special Interest:
  • Cancer Research
 

Liu, Yuangang, Ph.D.

Special Interest:
 

Lloyd, R. Stephen, Ph.D.

Lab Page

Special Interest:
 

Magun, Bruce, Ph.D

Special Interest:
 

Maurer, Richard, Ph.D.

Special Interest:
 

McCullough, Amanda K, Ph.D.

Special Expertise:
  • Environmental Exposure
  • oxidative stress
  • ultraviolet light-induced DNA damage
  • formaldehyde-induced DNA damage
  • DNA repair
 

Moses, Robb E., M.D.

Special Expertise:
  • Fanconi anemia
  • dna repair
 

Qian, David, Ph.D.

Special Expertise:
  • prostate
  • chemotherapy
  • hypoxia
  • genetics
  • metabolism
 

Scanlan, Thomas S., Ph.D.

Lab Page

Appointments:
Professor of Physiology and Pharmacology
Director, Program in Chemical Biology
 

Sears, Rosalie C., Ph.D.

Appointments:
Associate Professor  

Sherman, Larry, Ph.D

Special Expertise:
  • Myelination
  • Demyelinating diseases
  • Oligodendrocytes
  • Schwann cells
  • Multiple sclerosis
 

Skach, William, M.D.

Lab Page

Special Expertise:
  • Protein translocation
  • Polytopic membrane proteins
  • ER-associated degradation
 

Spellman, Paul, Ph.D.

Special Interest:
 

Thayer, Mathew, Ph.D.

Appointments:
Professor, Biochemistry & Molecular Biology Department
 

Turker, Mitchell, Ph.D., J.D.

Lab Page

Special Expertise:
  • Epigenetics
  • Gene silencing
  • Somatic Mutation
  • Radiation mutagenesis
  • Environmental Exposure
 

Wehrli, Marcel, Ph.D.

Lab Page

Special Expertise:
  • cancer
  • wnt/B-catenin signaling
  • axin
  • arrow
  • LDL receptor related protein (LRP)
 

Xiao, Xiangshu, Ph.D.

Appointments:
Assistant Professor, Department of Physiology and Pharmacology, OHSU
Member, Cancer Biology Program, Knight Cancer Institute, OHSU  

Yantasee, Wassana, Ph.D.

Lab Page

Special Interest:
 

Zundel, Wayne, Ph.D.

Lab Page

Appointments:
Director, Division of Molecular Radiation & Cancer Biology
Assistant Professor of Radiation Medicine
 

External Knight Cancer Institute Research Members

Researcher Research Area
 Peter Hurlin, Ph.D. Cell & Developmental Biology, Shriners
Jefferey Singer, Ph.D. Biochemistry & Molecular Biology, Portland State University
Scott Stadler, Ph.D. Molecular & Medical Genetics, Shriners