Longitudinal study of the course of ADHD.

Lead Investigator: This arm of the ADHD Program is directed by Dr. Joel Nigg, Ph.D..

Funding: This work is funded by the NIH, under grant R01 MH59105, and will continue until at least 2018.photo

OHSU Co-Investigators. Sarah Karalunas, Ph.D., Suzanne Mitchell, Ph.D..

Outside Co-Investigators and Consultants. Michelle Martel, Ph.D. (University of Kentucky), Erica Musser, Ph.D. (Florida International University), Michael Willoughby, Ph.D., (University of North Carolina), James McCracken, M.D., (UCLA), Helena Kraemer, Ph.D. (Stanford), and others.

Aims. The program is designed to better characterize the variety of clinical manifestations of ADHD over time. At OHSU, we see ADHD as comprising several conditions currently hidden under one umbrella diagnosis, analogously to how mental retardation (now called intellectual disability) or cancer were once seen as single diseases. The program is following a cohort of over 600 children from the greater Portland area, who are in the process of completing clinical, neuropsychological, physiological, and biological measurements on an annual or semi-annual basis. Over time, this effort will enable us to characterize the wide variety of physiological "types" that likely exist within ADHD, as well as the range of clinical outcomes. To date, we have already been able to identify promising typologies, integrate the role of emotional and cognitive difficulties, and initiate short term clinical prediction that can improve on existing clinical tools.

Productivity. To date this arm of the program has generated over 25 publications and an equal number of conference presentations, helping the field to recognize the possibilities for richer characterization of this complex condition.

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