Lewinsohn's Publications

50. Gold MC, McLaren JE, Reistetter JA, Smyk-Pearson S, Ladell K, Swarbrick GM, Yu YY, Hansen TH, Lund O, Nielsen M, Gerritsen B, Kesmir C, Miles JJ, Lewinsohn DA, Price DA, Lewinsohn DM. MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage. J Exp Med. 2014 Jul 28;211(8):1601-10. doi: 10.1084/jem.20140507. Epub 2014 Jul 21. PMID: 25049333

49. Lindestam Arlehamn CS, Lewinsohn D, Sette A, Lewinsohn D. Antigens for CD4 and CD8 T cells in tuberculosis. Cold Spring Harb Perspect Med. 2014 May 22;4(7):a018465. doi: 10.1101/cshperspect.a018465. PMID: 24852051

48. Alzhanova D, Hammarlund E, Reed J, Meermeier E, Rawlings S, Ray CA, Edwards DM, Bimber B, Legasse A, Planer S, Sprague J, Axthelm MK, Pickup DJ, Lewinsohn DM, Gold MC, Wong SW, Sacha JB, Slifka MK, Früh K. T cell inactivation by poxviral B22 family proteins increases viral virulence. PLoS Pathog. 2014 May 15;10(5):e1004123. doi: 10.1371/journal.ppat.1004123. eCollection 2014 May. PMID: 24832205

47. Harriff MJ, Cansler ME, Toren KG, Canfield ET, Kwak S, Gold MC, Lewinsohn DM. Human lung epithelial cells contain Mycobacterium tuberculosis in a late endosomal vacuole and are efficiently recognized by CD8⁺ T cells. PLoS One. 2014 May 14;9(5):e97515. doi: 10.1371/journal.pone.0097515. eCollection 2014. PMID: 24828674

44. Harriff MJ, Burgdorf S, Kurts C, Wiertz EJ, Lewinsohn DA, Lewinsohn DM. TAP mediates import of Mycobacterium tuberculosis-derived peptides into phagosomes and facilitates loading onto HLA-I. PLoS One. 2013 Nov 11;8(11):e79571. doi: 10.1371/journal.pone.0079571. eCollection 2013. PubMed PMID: 24244525

43. Lewinsohn DM, Swarbrick GM, Cansler ME, Null MD, Rajaraman V, Frieder MM, Sherman DR, McWeeney S, Lewinsohn DA. Human Mycobacterium tuberculosis CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide Library. PLoS One. 2013 Jun 21;8(6):e67016. Print 2013. PubMed PMID: 23805289

42. Gold MC, Lewinsohn DM. Co-dependents: MR1-restricted MAIT cells and their antimicrobial function. Nat Rev Microbiol. 2012 Nov 26;11(1):14-9. doi: 10.1038/nrmicro2918. Epub 2012 Nov 26. PubMed PMID: 23178389

41. Seshadri C, Turner MT, Lewinsohn DM, Moody DB, Van Rhijn I. Lipoproteins Are Major Targets of the Polyclonal Human T Cell Response to Mycobacterium tuberculosis. J Immunol. 2013 Jan 1;190(1):278-84. doi: 10.4049/jimmunol.1201667. Epub 2012 Nov 28. PubMed PMID: 23197260; PubMed Central PMCID: PMC3529834

40. Gold MC, Eid T, Smyk-Pearson S, Eberling Y, Swarbrick GM, Langley SM, Streeter PR, Lewinsohn DA, Lewinsohn DM. Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress. Mucosal Immunol.2012 Jun 13. doi: 10.1038/mi.2012.45. [Epub ahead of print] PubMed PMID: 22692454; PubMed Central PMCID: PMC3443511

39. Harriff MJ, Purdy GE, Lewinsohn DM. Escape from the Phagosome: The Explanation for MHC-I Processing of Mycobacterial Antigens? Front Immunol. 2012;3:40. Epub 2012 Mar 5. PubMed PMID: 22566923; PubMed Central PMCID: PMC3342008

38. Lancioni C, Nyendak M, Kiguli S, Zalwango S, Mori T, Mayanja-Kizza H, Balyejusa S, Null M, Baseke J, Mulindwa D, Byrd L, Swarbrick G, Scott C, JohnsonDF, Malone L, Mudido-Musoke P, Boom WH, Lewinsohn DM, Lewinsohn DA; TuberculosisResearch Unit. CD8+ T cells provide an immunologic signature of tuberculosis in young children. Am J Respir Crit Care Med. 2012 Jan 15;185(2):206-12. Epub 2011 Oct 27. PubMed PMID: 22071329; PubMed Central PMCID: PMC3297089

37. Gold MC, Lewinsohn DM. Mucosal associated invariant T cells and the immune response to infection. Microbes Infect. 2011 Aug;13(8-9):742-8. Epub 2011 Mar 31. Review. PubMed PMID: 21458588; PubMed Central PMCID: PMC3130845

36. Lewinsohn DA, Gold MC, Lewinsohn DM. Views of immunology: effector T cells. Immunol Rev. 2011 Mar;240(1):25-39. doi: 10.1111/j.1600-065X.2010.00997.x. Review. PubMed PMID: 21349084.

35. Wang M, Tang ST, Stryhn A, Justesen S, Larsen MV, Dziegiel MH, Lewinsohn DM, Buus S, Lund O, Claesson MH. Identification of MHC class II restricted T-cell-mediated reactivity against MHC class I binding Mycobacterium tuberculosis peptides. Immunology. 2011 Apr;132(4):482-91. doi: 10.1111/j.1365-2567.2010.03383.x. Epub 2011 Feb 7. PubMed PMID: 21294723; PubMedCentral PMCID: PMC3075502.

34. Grotzke JE, Siler AC, Lewinsohn DA, Lewinsohn DM. Secreted immunodominant Mycobacterium tuberculosis antigens are processed by the cytosolic pathway. J Immunol. 2010 Oct 1;185(7):4336-43. Epub 2010 Aug 27. PubMed PMID: 20802151; PubMed Central PMCID: PMC2988655.

33. Gold MC, Cerri S, Smyk-Pearson S, Cansler ME, Vogt TM, Delepine J, Winata E, Swarbrick GM, Chua WJ, Yu YY, Lantz O, Cook MS, Null MD, Jacoby DB, Harriff MJ, Lewinsohn DA, Hansen TH, Lewinsohn DM. Human mucosal associated invariant T cells detect bacterially infected cells. PLoS Biol. 2010 Jun 29;8(6):e1000407. PubMed PMID: 20613858; PubMed Central PMCID: PMC2893946

32. Frieder M, Lewinsohn DM. T-cell epitope mapping in Mycobacterium tuberculosis using pepmixes created by micro-scale SPOT- synthesis. Methods Mol Biol. 2009;524:369-82. PubMed PMID: 19377959

31. Grotzke JE, Harriff MJ, Siler AC, Nolt D, Delepine J, Lewinsohn DA, Lewinsohn DM. The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle. PLoS Pathog. 2009 Apr;5(4):e1000374. Epub 2009 Apr 10. PubMed PMID: 19360129; PubMed Central PMCID: PMC2661020

30. Nyendak MR, Lewinsohn DA, Lewinsohn DM. New diagnostic methods for tuberculosis. Curr Opin Infect Dis. 2009 Apr;22(2):174-82. Review. PubMed PMID: 19283913

29. Schillace RV, Miller CL, Pisenti N, Grotzke JE, Swarbrick GM, Lewinsohn DM, Carr DW. A-kinase anchoring in dendritic cells is required for antigen presentation. PLoS One. 2009;4(3):e4807. Epub 2009 Mar 11. PubMed PMID: 19277197; PubMed Central PMCID: PMC2652104

28. Winthrop KL, Nyendak M, Calvet H, Oh P, Lo M, Swarbrick G, Johnson C, Lewinsohn DA, Lewinsohn DM, Mazurek GH. Interferon-gamma release assays for diagnosing mycobacterium tuberculosis infection in renal dialysis patients. Clin J Am Soc Nephrol. 2008 Sep;3(5):1357-63. Epub 2008 Jun 11. PubMed PMID: 18550653; PubMed Central PMCID: PMC2518786

27. Gold MC, Ehlinger HD, Cook MS, Smyk-Pearson SK, Wille PT, Ungerleider RM, Lewinsohn DA, Lewinsohn DM. Human innate Mycobacterium tuberculosis-reactive alphabetaTCR+ thymocytes. PLoS Pathog. 2008 Feb 8;4(2):e39. PubMed PMID: 18282101; PubMed Central PMCID: PMC2242840

26. Lewinsohn DA, Lewinsohn DM. Immunologic susceptibility of young children to Mycobacterium tuberculosis. Pediatr Res. 2008 Feb;63(2):115. PubMed PMID: 18209663

25. Blythe MJ, Zhang Q, Vaughan K, de Castro R Jr, Salimi N, Bui HH, Lewinsohn DM, Ernst JD, Peters B, Sette A. An analysis of the epitope knowledge related to Mycobacteria. Immunome Res. 2007 Dec 14;3:10. PubMed PMID: 18081934; PubMed Central PMCID: PMC2228276

24. Khan IH, Ravindran R, Yee J, Ziman M, Lewinsohn DM, Gennaro ML, Flynn JL, Goulding CW, DeRiemer K, Lerche NW, Luciw PA. Profiling antibodies to Mycobacterium tuberculosis by multiplex microbead suspension arrays for serodiagnosis of tuberculosis. Clin Vaccine Immunol. 2008 Mar;15(3):433-8. Epub 2007 Dec 12. PubMed PMID: 18077619; PubMed Central PMCID: PMC2268277

23. Ernst JD, Lewinsohn DM, Behar S, Blythe M, Schlesinger LS, Kornfeld H, Sette A. Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database. Tuberculosis (Edinb). 2008 Jul;88(4):366-70. Epub 2007 Dec 18. PubMed PMID: 18068490; PubMed Central PMCID: PMC2504685

22. Gold MC, Robinson TL, Cook MS, Byrd LK, Ehlinger HD, Lewinsohn DM, Lewinsohn DA. Human neonatal dendritic cells are competent in MHC class I antigen processing and presentation. PLoS One. 2007 Sep 26;2(9):e957. PubMed PMID: 17895997; PubMed Central PMCID: PMC1978526

21. Lewinsohn DA, Winata E, Swarbrick GM, Tanner KE, Cook MS, Null MD, Cansler ME, Sette A, Sidney J, Lewinsohn DM. Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B. PLoS Pathog. 2007 Sep 21;3(9):1240-9. PubMed PMID: 17892322; PubMed Central PMCID: PMC2323292

20. Lewinsohn DM, Tydeman IS, Frieder M, Grotzke JE, Lines RA, Ahmed S, Prongay KD, Primack SL, Colgin LM, Lewis AD, Lewinsohn DA. High resolution radiographic and fine immunologic definition of TB disease progression in the rhesus macaque. Microbes Infect. 2006 Sep;8(11):2587-98. Epub 2006 Aug 14. PubMed PMID: 16952476

19. Smyk-Pearson S, Tester IA, Lezotte D, Sasaki AW, Lewinsohn DM, Rosen HR. Differential antigenic hierarchy associated with spontaneous recovery from hepatitis C virus infection: implications for vaccine design. J Infect Dis. 2006 Aug 15;194(4):454-63. Epub 2006 Jul 12. PubMed PMID: 16845628

18. Lewinsohn DM, Grotzke JE, Heinzel AS, Zhu L, Ovendale PJ, Johnson M, Alderson MR. Secreted proteins from Mycobacterium tuberculosis gain access to the cytosolic MHC class-I antigen-processing pathway. J Immunol. 2006 Jul 1;177(1):437-42. PubMed PMID: 16785540.

16. Tester I, Smyk-Pearson S, Wang P, Wertheimer A, Yao E, Lewinsohn DM, Tavis JE, Rosen HR. Immune evasion versus recovery after acute hepatitis C virus infection from a shared source. J Exp Med. 2005 Jun 6;201(11):1725-31. PubMed PMID: 15939788; PubMed Central PMCID: PMC2213272

15. Grotzke JE, Lewinsohn DM. Role of CD8+ T lymphocytes in control of Mycobacterium tuberculosis infection. Microbes Infect. 2005 Apr;7(4):776-88. Epub 2005 Mar 16. Review. PubMed PMID: 15823514

14. Salerno-Gonçalves R, Fernandez-Viña M, Lewinsohn DM, Sztein MB. Identification of a human HLA-E-restricted CD8+ T cell subset in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine. J Immunol. 2004 Nov 1;173(9):5852-62. PubMed PMID: 15494539

13. Rosen HR, Hinrichs DJ, Leistikow RL, Callender G, Wertheimer AM, Nishimura MI, Lewinsohn DM. Cutting edge: identification of hepatitis C virus-specific CD8+ T cells restricted by donor HLA alleles following liver transplantation. J Immunol. 2004 Nov 1;173(9):5355-9. PubMed PMID: 15494481

12. Lewinsohn DA, Gennaro ML, Scholvinck L, Lewinsohn DM. Tuberculosis immunology in children: diagnostic and therapeutic challenges and opportunities. Int J Tuberc Lung Dis. 2004 May;8(5):658-74. Review. PubMed PMID: 15137550

11. Guinn KM, Hickey MJ, Mathur SK, Zakel KL, Grotzke JE, Lewinsohn DM, Smith S, Sherman DR. Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis. Mol Microbiol. 2004 Jan;51(2):359-70. PubMed PMID: 14756778; PubMed Central PMCID: PMC1458497

10. Lewinsohn DM, Lewinsohn DA, Grotzke JE. TB vaccines at the turn of the century: insights into immunity to M. tuberculosis and modern approaches for prevention of an ancient disease. Semin Respir Infect. 2003 Dec;18(4):320-38. Review. PubMed PMID: 14679479

9. Lewinsohn DA, Heinzel AS, Gardner JM, Zhu L, Alderson MR, Lewinsohn DM. Mycobacterium tuberculosis-specific CD8+ T cells preferentially recognize heavily infected cells. Am J Respir Crit Care Med. 2003 Dec 1;168(11):1346-52. Epub 2003 Sep 11. PubMed PMID: 12969871

8. Heinzel AS, Grotzke JE, Lines RA, Lewinsohn DA, McNabb AL, Streblow DN, Braud VM, Grieser HJ, Belisle JT, Lewinsohn DM. HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells. J Exp Med. 2002 Dec 2;196(11):1473-81. PubMed PMID: 12461082; PubMed Central PMCID: PMC2194265

7. Lewinsohn DA, Lines RA, Lewinsohn DM. Human dendritic cells presenting adenovirally expressed antigen elicit Mycobacterium tuberculosis--specific CD8+ T cells. Am J Respir Crit Care Med. 2002 Sep 15;166(6):843-8. PubMed PMID: 12231495

6. Lewinsohn DA, Lines R, Lewinsohn DM, Riddell SR, Greenberg PD, Emerman M, Bartz SR. HIV-1 Vpr does not inhibit CTL-mediated apoptosis of HIV-1 infected cells. Virology. 2002 Mar 1;294(1):13-21. PubMed PMID: 11886261

5. Davey MP, Rosen HR, Woody CN, Haley DP, Kurkinen J, Lewinsohn DM. T-cell clones derived by CD3 stimulation from hepatitis C virus explanted liver tissue are not representative of dominant clones present in vivo. Liver Transpl. 2001 Aug;7(8):716-23. PubMed PMID: 11510018

4. Lewinsohn DM, Zhu L, Madison VJ, Dillon DC, Fling SP, Reed SG, Grabstein KH, Alderson MR. Classically restricted human CD8+ T lymphocytes derived from Mycobacterium tuberculosis-infected cells: definition of antigenic specificity. J Immunol. 2001 Jan 1;166(1):439-46. PubMed PMID: 11123322

3. Lewinsohn DM, Briden AL, Reed SG, Grabstein KH, Alderson MR. Mycobacterium tuberculosis-reactive CD8+ T lymphocytes: the relative contribution of classical versus nonclassical HLA restriction. J Immunol. 2000 Jul 15;165(2):925-30. PubMed PMID: 10878367

2. Lewinsohn DM, Alderson MR, Briden AL, Riddell SR, Reed SG, Grabstein KH. Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells. J Exp Med. 1998 May 18;187(10):1633-40. PubMed PMID: 9584141; PubMed Central PMCID: PMC2212289

1. Lewinsohn DM, Bement TT, Xu J, Lynch DH, Grabstein KH, Reed SG, Alderson MR. Human purified protein derivative-specific CD4+ T cells use both CD95-dependent and CD95-independent cytolytic mechanisms. J Immunol. 1998 Mar 1;160(5):2374-9. PubMed PMID: 9498779