Melissa Weimer, D.O., M.C.R.

Melissa Weimer, MD Melissa Weimer, D.O., M.C.R.
Assistant Professor of Medicine
Division of General Internal Medicine and Geriatrics

Education and Training

BA, High Honors, University of Virginia

Medical Degree:
D.O., Honors, VIrginia College of Osteopathic Medicine

General Internal Medicine, Oregon Health & Science University

General Internal Medicine, Oregon Health & Science University

Master's Degree:
MCR, Oregon Health & Science University


Melissa B. Weimer, DO specializes in the interface between General Internal Medicine and Addiction. Her clinical and research interests are the safe and effective treatment of chronic pain in the primary care setting. In addition to general medicine, she treats chronic pain, chronic pain in the setting of opioid addiction, and opioid dependency. She uses suboxone therapy when indicated and also treats opioid dependency with methadone at CODA, Inc. In addition to her individual practice, she has developed a novel teaching clinic for the treatment of complex chronic pain called PROPEL (Pain Relief to Optimize Proactive Engagement with Life). PROPEL teaches Internal Medicine housestaff how to care for patients using a multimodal approach to chronic pain. Dr. Weimer is the Chair of the Pain Task Force for the Internal Medicine Practice. Dr. Weimer enjoys spending time with her family. She is an avid gardener who also enjoys running, biking, and hiking.

Board Certification

Internal Medicine, American Board of Internal Medicine, 2010
Addiction Medicine, American Board of Addiction Medicine, 2012

Research Interests

  • American Pain Society and College of Problems of Drug Dependence Private Funding, Sytematic Review of Methadone Safety and Efficacy
  • Gender Comparisons in Chronic Opioid Therapy for VA users
  • Cocaine Use Reduction with Buprenorphine (CURB)

Recent Research Projects

PI: Melissa Weimer, DO, MCR
MARC (Methamphetamine Abuse Research Center)
Title: Neuroadaptive Circadian Rhythm Changes with Methamphetamine Dependence
Methamphetamine (MA) use is epidemic in the United States. In Oregon, substance abuse treatment admissions for MA are the highest in the country. These are important statistics because MA dependency is associated with high morbidity and mortality including depressive symptoms and increased risk for suicide above that of other chemical dependencies. Strong evidence also supports correlations between circadian misalignment and symptoms of depression and anxiety. Despite these associations very little is known about the correlation between MA dependency and circadian misalignment. In rats, MA administration has been shown to affect circadian oscillators and induce circadian misalignment, which can be measured by the phase angle difference (PAD). This study proposes to translate these neuroadaptive observations to humans. We hypothesize that preclinical observations of MA-induced circadian phase delay is also present in humans with MA dependence and can be reliably assessed by previously validated circadian misalignment measures (PAD).

PI: Melissa Weimer, DO, MCR
SGIM Founders Grant
Title: Evaluating a Chronic Opioid Therapy Dose Reduction Policy in Primary Care
High dose opioids prescribed for the treatment of chronic pain have been associated with increased risk of unintentional opioid overdose. Multiple clinics in the Pacific Northwest responded to this concern with new opioid dose limitation practice policies. Despite these changes, there is sparse evidence showing the effectiveness of these measures or their impact on patient outcomes. This application proposes to gather preliminary data exploring the impact of this policy in one clinical setting.

Selected Publications

  1. Weimer, MB, Chou, R. Research Gaps on Methadone Harms and Comparative Harms: Findings from a Review of the Evidence for an American Pain Society and College of Problems of Drug Dependence Clinical Practice Guideline. Journal of Pain 2014; 15(4):366-376. PMID: 24685460.
  2. Chou, R, Weimer, MB, Dana, T. Methadone Overdose and Cardiac Arrhythmia Potential: Findings from a Review of the Evidence for an American Pain Society and College of Problems of Drug Dependence Clinical Practice Guideline. Journal of Pain 2014; 15(4): 338-365. PMID: 24685459.
  3. Chou, R, Weimer, MB, Dana T, Walker M, Mitchell JP. Systematic Evidence Review on Methadone Harms and Comparative Harms. Glenview, IL: American Pain Society; 2012. Available at
  4. Weimer, MB, Gideonse, N, Mauer, K, Stacey, B. Oregon Health and Science University Opioid Guideline for  Safe Chronic Opioid Therapy Prescribing for Patients with Chronic Non-cancer Pain. August 2013. Available at 
  5. Melissa B. Weimer DO, MCR, Tara A. Macey PhD, Christina Nicolaidis MD, MPH, Steven K. Dobscha MD, Jonathan P. Duckart MPS, Benjamin J. Morasco PhD. Sex Differences in the Medical Care of VA Patients with Chronic Non-Cancer Pain. Article first published online: 26 JUN 2013 DOI: 10.1111/pme.12177
  6. Scott, DR, Weimer, MB, English, C, Shaker, L, Ward, W, Choi, D, Cedfeldt, A, Girard, D. A Novel Approach to Increase Resident Involvement in Reporting Adverse Events. Academic Medicine. 2011 June; 86(6):742-746. PMID: 21512369.
  7. Weimer, MB, Korthuis, PT, Behonick, G, Wunsch, MJ. The Source of Methadone in Overdose Deaths in Western Virginia in 2004. Journal of Addiction Medicine 2011 September; 5(3): 188-202. PMID: 21844834.

Clinical Interests

Chronic pain care, opioid addiction

Educational Activities

Topic Lead for the Chronic pain curriculum for our Internal Medicine Ambulatory Curriculum

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