Two Important Publications from APOM

09/19/14  Portland, OR

The following two studies have just been accepted for publication:

1. "Peroxisomal Biogenesis in Ischemic Brain" by Jennifer Young, Jonathan Nelson, Jian Chen, Wenri Zhang, Sarah Mader, Catherine Davis, Richard Morrison and Nabil Alkayed have been accepted in Antioxidants & Redox Signaling (ARS). I appears online ahead of print. 

The study found that peroxisomes, small intracellular organelles, proliferate in neurons under ischemic conditions, and that peroxisomal proliferation plays a protective role against ischemic neuronal injury.

2. "Role of Soluble Epoxide Hydrolase in Age-related Vascular Cognitive Decline" by Jonathan Nelson, Jennifer Young, Rohan Borkar, Randy Woltjer, Joseph Quinn, Lisa C. Silbert, Marjorie Grafe and Nabil Alkayed has just been accepted in Prostaglandins & Other Lipid Mediators (POLM).

The study used human brain tissue from the Oregon Alzheimer's Disease & Aging Center tissue bank and found an enzyme called soluble epoxide hydrolase (sEH) to be increased in microvascular endothelium from brains identified to have dementia of vascular origin. The study also found an association between a variant in the gene for sEH, called ephx2, and white matter damage in aging brain (identified as T2 white matter hyperintensity on premortem MRI).

Nabil Alkayed
Professor and Vice Chair for Research
Department of Anesthesiology & Perioperative Medicine
Oregon Health & Science University