Recent Publications

Slaker ML, Jorgensen ET, Hegarty DM, Liu X, Kong Y, Zhang F, Linhardt RJ, Brown TE, Aicher SA, Sorg BA. Cocaine Exposure Modulates Perineuronal Nets and Synaptic Excitability of Fast-Spiking Interneurons in the Medial Prefrontal Cortex. eNeuro. 2018 Oct 4;5(5). pii: ENEURO.0221-18.2018. doi: 10.1523/ENEURO.0221-18.2018. eCollection 2018 Sep-Oct. PubMed PMID: 30294670; PubMed Central PMCID: PMC6171740.

Hegarty DM, Hermes SM, Morgan MM, Aicher SA (2018) Acute hyperalgesia and delayed dry eye after corneal abrasion injury. Pain Reports June 20, 2018 doi: 10.1097/PR9.0000000000000664

Winters BL, Gregoriou GC, Kissiwaa SA, Wells OA, Medagoda DI, Hermes SM, Burford NT, Alt A, Aicher SA, Bagley EE. Endogenous opioids regulate moment-to-moment neuronal communication and excitability. Nat Commun. 2017 Mar 22;8:14611. doi: 10.1038/ncomms14611. PubMed PMID: 28327612

Hegarty DM, Hermes SM, Yang K, Aicher SA. Select noxious stimuli induce changes on corneal nerve morphology. J Comp Neurol. 2017 Jun 1;525(8):2019-2031. doi: 10.1002/cne.24191. Epub 2017 Mar 14. PubMed PMID: 28213947

McDougall SJ, Guo H, Andresen MC. Dedicated C-fibre viscerosensory pathways to central nucleus of the amygdala. J Physiol. 2017 Feb 1;595(3):901-917. doi: 10.1113/JP272898. Epub 2016 Oct 25. PubMed PMID: 27616729; PubMed Central PMCID: PMC5285724. 

Hofmann ME, Andresen MC. Dynasore blocks evoked release while augmenting spontaneous synaptic transmission from primary visceral afferents. PLoS One. 2017 Mar 30;12(3):e0174915. doi: 10.1371/journal.pone.0174915. eCollection 2017. PubMed PMID: 28358887; PubMed Central PMCID: PMC5373620.  

Beaumont E, Campbell RP, Andresen MC, Scofield S, Singh K, Libbus I, KenKnight BH, Snyder L, Cantrell N. Cervical vagus nerve stimulation augments spontaneous discharge in second- and higher-order sensory neurons in the rat nucleus of the solitary tract. Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H354-H367. doi: 10.1152/ajpheart.00070.2017. Epub 2017 May 5. PubMed PMID: 28476920; PubMed Central PMCID: PMC5582922. 

Mohammed M, Madden CJ, Andresen MC, Morrison SF. Activation of TRPV1 in nucleus tractus solitarius reduces brown adipose tissue thermogenesis, arterial pressure, and heart rate. Am J Physiol Regul Integr Comp Physiol. 2018 Jul 1;315(1):R134-R143. doi: 10.1152/ajpregu.00049.2018. Epub 2018 Mar 28. PubMed PMID: 29590555; PubMed Central PMCID: PMC6087884.

Shi Z, Madden CJ, Brooks VL. Arcuate neuropeptide Y inhibits sympathetic nerve activity via multiple neuropathways. J Clin Invest. 2017 Jun 30;127(7):2868-2880. doi: 10.1172/JCI92008. Epub 2017 Jun 19. PubMed PMID: 28628036; PubMed Central PMCID: PMC5490747.  

Komegae EN, Farmer DGS, Brooks VL, McKinley MJ, McAllen RM, Martelli D. Vagal afferent activation suppresses systemic inflammation via the splanchnic anti-inflammatory pathway. Brain Behav Immun. 2018 Oct;73:441-449. doi: 10.1016/j.bbi.2018.06.005. Epub 2018 Jun 5. PubMed PMID: 29883598.

Carter-O’Connell, I.O., Vermehren-Schmaedick, A, Jin, H, Haihong Jin, Morgan, R.K., David, L.L., Cohen, M.S Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14)., ACS Chemical Biology, Article ASAP (2018).

Kirby, I.T. and Cohen, M.S. "Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapuetics." Current Topics in Microbiology and Immunology, (2018). Cohen, M.S. and Chang, P. “Insights into the biogenesis, function, and regulation of ADP-ribosylation,” Nature Chemical Biology, 14, 236 (2018). 

Cohen, M.S., Stewart, M.L., Goodman, R.H., Cambronne, X.A. “Methods for using a genetically encoded fluorescent biosensor to monitor nuclear NAD,” Methods in Molecular Biology, 1813, 391 (2018).  Kirby, I.T., Morgan, R.K., and Cohen, M.S. “A simple, sensitive, and generalizable plate assay for screening PARP inhibitors,” Methods in Molecular Biology, 1813, 245 (2018).  

Morgan, R.K, and Cohen, M.S. “Detecting protein ADP-ribosylation using a clickable aminooxy probe,” Methods in Molecular Biology, 1601, 71 (2017).

Cohen, M.S. “Axon Degeneration: Too Much NMN is Actually Bad,” Current Biology, 27, R310 (2017).Thorsell, A.G., Ekblad, T. Karlberg, T., Low, M., Pinto, A.F., Tresaugues, L., Moche, M., Cohen, M.S., and Schuler, H. “Structural Basis for Potency and Promiscuity in Poly)ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors,” Journal of Medicinal Chemistry, 60, 1262 (2017).Cambronne, X.A.*,Stewart, M.L., Kim, D., Jones-Brunette, A.M., Morgan, R.K., Farrens, D.L.,Cohen, M.S.*, Goodman, R.H. "Biosensor reveals multiple sources for mitochondrial NAD+," Science 352, 1474 (2016). *corresponding authors
Featured in: Perspectives: Science, 352, 1396 (2017) and Research Highlights: Nature Methods, 13, 610 (2017)Torres ERS, Akinyeke T, Stagaman K, Duvoisin RM, Meshul CK, Sharpton TJ, Raber J. Effects of Sub-Chronic MPTP Exposure on Behavioral and Cognitive Performance and the Microbiome of Wild-Type and mGlu8 Knockout Female and Male Mice. Front Behav Neurosci. 2018 Jul 18;12:140. doi: 10.3389/fnbeh.2018.00140. eCollection 2018. PubMed PMID: 30072879; PubMed Central PMCID: PMC6058038.  Hitchcock P, Mathur A, Bennett J, Cameron P, Chow C, Clifford P, Duvoisin R, Feig A, Finneran K, Klotz DM, McGee R, O'Riordan M, Pfund C, Pickett C, Schwartz N, Street NE, Watkins E, Wiest J, Engelke D. The future of graduate and postdoctoral training in the biosciences. Elife. 2017 Oct 19;6. pii: e32715. doi: 10.7554/eLife.32715. PubMed PMID: 29049023; PubMed Central PMCID: PMC5648525. Duvoisin RM, Haley TL, Ren G, Strycharska-Orczyk I, Bonaparte JP, Morgans CW. Autoantibodies in Melanoma-Associated Retinopathy Recognize an Epitope Conserved Between TRPM1 and TRPM3. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2732-2738. doi: 10.1167/iovs.17-21443. PubMed PMID: 28549093; PubMed Central PMCID: PMC5455167.

Vaseghi, M., Yagishita, D., Rajendran, P.J., Woodward, W.R., Hamon, D., Yamakawa, K., Irie, T., Habecker B.A., and Shivkumar, K. Parasympathetic Dysfunction and Mechanistic Basis of Anti-arrhythmic Effects of Vagal Nerve Stimulation Following Myocardial Infarction.  JCI Insight. 2017 Aug 17;2(16). pii: 86715. doi: 10.1172/jci.insight.86715. 2017 PMCID: PMC5621871

Murphy, S.R., Wang, L., Wang, Z., Domondon, P., Lang, D., Habecker, B.A., Myles, R.C., and Ripplinger, C.M. (2017) β-adrenergic inhibition prevents action potential and calcium handling changes during regional myocardial ischemia.  Frontiers in Physiology, Aug 28;8:630. doi: 10.3389/fphys.2017.00630. eCollection 2017. PMCID: PMC5581400

Parrish, D.C., Olivas, A., Francis Stuart, S.D., Wang, L., Nykjaer, A., Ripplinger, C.M., and Habecker, B.A. (2018) Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility. AJP:Heart and Circulatory Physiology. 314(3):H415-H423. doi: 10.1152/ajpheart.00300.2017. PMCID: PMC5899257

Denfeld, Q.E., Habecker B.A., and Woodward, W.R. (2018) Measurement of Plasma Norepinephrine and 3,4-Dihydroxyphenylglycol: Method Development for a Translational Research Study. BMC Research Notes, 11(1):248. doi: 10.1186/s13104-018-3352-3. PMCID: PMC5909231 

Bayles R.G., Olivas A., Denfeld Q., Woodward W.R., Fei S.S., Gao L., Habecker B.A. (2018) Transcriptomic and neurochemical analysis of the stellate ganglia in mice highlights sex differences. Scientific Reports, 8(1):8963. doi: 10.1038/s41598-018-27306-3. 

Francis Stuart SD, Wang L, Woodard WR, Ng GA, Habecker BA, Ripplinger CM. Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation. J Physiol. 2018 Jun 25. doi: 10.1113/JP276396. [Epub ahead of print] PubMed PMID: 29938794.

Veruki ML, Zhou Y, Castilho Á, Morgans CW, Hartveit E. Extrasynaptic NMDA receptors on rod pathway amacrine cells: molecular composition, activation, and signaling. J Neurosci. 2018 Nov 20. pii: 2267-18. doi: 10.1523/JNEUROSCI.2267-18.2018. [Epub ahead of print] PubMed PMID: 30459218.

Stincic TL, Grachev P, Bosch MA, Rønnekleiv OK, Kelly MJ. Estradiol Drives the Anorexigenic Activity of Proopiomelanocortin Neurons in Female Mice. eNeuro. 2018 Oct 10;5(4). pii: ENEURO.0103-18.2018. doi: 10.1523/ENEURO.0103-18.2018. eCollection 2018 Jul-Aug. PubMed PMID: 30310864; PubMed Central PMCID: PMC6179576.

Vazquez MJ, Toro CA, Castellano JM, Ruiz-Pino F, Roa J, Beiroa D, Heras V, Velasco I, Dieguez C, Pinilla L, Gaytan F, Nogueiras R, Bosch MA, Rønnekleiv OK, Lomniczi A, Ojeda SR, Tena-Sempere M. SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression. Nat Commun. 2018 Oct 10;9(1):4194. doi: 10.1038/s41467-018-06459-9. PubMed PMID: 30305620; PubMed Central PMCID: PMC6179991.

Qiu J, Bosch MA, Meza C, Navarro UV, Nestor CC, Wagner EJ, Rønnekleiv OK, Kelly MJEstradiol Protects Proopiomelanocortin Neurons Against Insulin Resistance. Endocrinology. 2018 Feb 1;159(2):647-664. doi: 10.1210/en.2017-00793. PubMed PMID: 29165691; PubMed Central PMCID: PMC5774249.

Padilla SL, Qiu J, Nestor CC, Zhang C, Smith AW, Whiddon BB, Rønnekleiv OK, Kelly MJ, Palmiter RD. AgRP to Kiss1 neuron signaling links nutritional state and fertility. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2413-2418. doi: 10.1073/pnas.1621065114. Epub 2017 Feb 14. Erratum in: Proc Natl Acad Sci U S A. 2017 Apr 25;114(17 ):E3584. PubMed PMID: 28196880; PubMed Central PMCID: PMC5338482.

Kelly MJ, Qiu J, Rønnekleiv OK.TRPCing around the hypothalamus. Front Neuroendocrinol. 2018 May 31. pii: S0091-3022(18)30042-6. doi: 10.1016/j.yfrne.2018.05.004. [Epub ahead of print] Review. PubMed PMID: 29859883

Asquith M, Davin S, Stauffer P, Michell C, Janowitz C, Lin P, Ensign-Lewis J, Kinchen JM, Koop DR, Rosenbaum JT. Intestinal Metabolites Are Profoundly Altered in the Context of HLA-B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis. Arthritis Rheumatol. 2017 Oct;69(10):1984-1995. doi: 10.1002/art.40183. Epub 2017 Aug 31. PubMed PMID: 28622455

Al-Uzri A, Freeman KA, Wade J, Clark K, Bleyle LA, Munar M, Koop DR. Longitudinal study on the use of dried blood spots for home monitoring in children after kidney transplantation. Pediatr Transplant. 2017 Sep;21(6). doi: 10.1111/petr.12983. Epub 2017 Jun 20. PubMed PMID: 28635157

Frueh L, Li Y, Mather MW, Li Q, Pou S, Nilsen A, Winter RW, Forquer IP, Pershing AM, Xie LH, Smilkstein MJ, Caridha D, Koop DR, Campbell RF, Sciotti RJ, Kreishman-Deitrick M, Kelly JX, Vesely B, Vaidya AB, Riscoe MK. Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria. ACS Infect Dis. 2017 Oct 13;3(10):728-735. doi: 10.1021/acsinfecdis.7b00062. Epub 2017 Sep 27. PubMed PMID: 28927276

Mirto AJ, Austin KJ, Uthlaut VA, Roselli CE, Alexander BM. Fos Expression in the Olfactory Pathway of High- and Low-Sexually Performing Rams Exposed to Urine from Estrous or Ovariectomized Ewes. Appl Anim Behav Sci. 2017 Jan;186:22-28. doi: 10.1016/j.applanim.2015.09.001. Epub 2015 Sep 21. PubMed PMID: 28348447

Scully CM, Estill CT, Amodei R, McKune A, Gribbin KP, Meaker M, Stormshak F, Roselli CE. Early prenatal androgen exposure reduces testes size and sperm concentration in sheep without altering neuroendocrine differentiation and masculine sexual behavior. Domest Anim Endocrinol. 2018 Jan;62:1-9. doi: 10.1016/j.domaniend.2017.07.001. Epub 2017 Jul 29. PubMed PMID: 28843181

Kramer AC, Mirto AJ, Austin KJ, Roselli CE, Alexander BM. Tyrosine hydroxylase in the ventral tegmental area of rams with high or low libido-A role for dopamine. Anim Reprod Sci. 2017 Dec;187:152-158. doi: 10.1016/j.anireprosci.2017.10.019. Epub 2017 Oct 31. PubMed PMID: 29100664

Roselli CE. Neurobiology of gender identity and sexual orientation. J Neuroendocrinol. 2018 Jul;30(7):e12562. doi: 10.1111/jne.12562. Review. PubMed PMID: 29211317

Heck AL, Crestani CC, Fernández-Guasti A, Larco DO, Mayerhofer A, Roselli CE. Neuropeptide and steroid hormone mediators of neuroendocrine regulation. J Neuroendocrinol. 2018 Apr 12:e12599. doi: 10.1111/jne.12599

Meinig JM, Ferrara SJ, Banerji T, Banerji T, Sanford-Crane HS, Bourdette D, Scanlan TS. Targeting Fatty-Acid Amide Hydrolase with Prodrugs for CNS-Selective Therapy. ACS Chem Neurosci. 2017 Nov 15;8(11):2468-2476. doi: 10.1021/acschemneuro.7b00239. Epub 2017 Aug 18. PubMed PMID: 28756656

Devereaux J, Ferrara SJ, Scanlan TS. Quantification of Thyromimetic Sobetirome Concentration in Biological Tissue Samples. Methods Mol Biol. 2018;1801:193-206. doi: 10.1007/978-1-4939-7902-8_16. PubMed PMID: 29892826

Yu, X., Akbarzadeh, R., Pieper, M., Scholzen, T., Gehrig, S., Schultz, C., Zillikens, D., König, P., Petersen, F. Neutrophil adhesion is a prerequisite for antibody-mediated proteolytic tissue damage in experimental models of epidermolysis bullosa acquisita. J. Invest. Dermatol. (2018). doi: 10.1016/j.jid.2018.03.1499Marat, A., Wallroth, A., Lo, W.-T., Mueller, R., Norata, G. D., Falasca, M., Schultz, C., Haucke, V. "Phosphatidylinositol 3,4-bisphosphate represses nutrient signaling by mTORC1" Science 356, 968-972 (2017).

Frank,, J. A., Yushchenko, D. A., Fine, N. H. F., Duca, M., Citir, M., Broichhagen, J., Hodson, D. J., Schultz, C., Trauner, D. Optical control of GPR40 signalling in pancreatic ß-cells. Chem. Sci. 8, 7604-7610 (2017). doi: 10.1039/c7sc01475a

Müksch, F., Laketa, V., Müller, B., Schultz, C., Kräusslich, H.-G. Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring. eLife 6, e25287 (2017).

Zuidscherwoude, M., Dunlock, V.-M. E., van den Bogaart, G., van Deventer, S.J., van der Schaaf, A., van Oostrum, J., Goedhart, J., In 't Hout, J., Hämmerling, G. J., Tanaka, S., Nadler, A., Schultz, C., Wright, M. D., Adjobo-Hermans, M. J. W., van Spriel, A. B. Tetraspanin microdomains control localized protein kinase C signaling in B cells. Sci. Signal. 10, eaag2755 (2017).

Walter*, A., Mueller, R., Wierda, K. D. B., Tawfik, B., Pinheiro, P. S., Nadler, A., Ziomkiewicz, I., Kruse, M., Reither, G., Rettig, J., Haucke, V., Hille, B., Schultz*, C., Soerensen*, J. Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis, eLife 6, e30203 (2017). DOI: https://doi.org/10.7554/eLife.30203

Dittrich, A. S., Kuehbandner, I., Gehrig, S., Rickert-Zacharias, V., Twigg, M., Wege, S., Taggert, C., Herth, F., Schultz, C., Mall, M. Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis. Eur. Resp. J. 29, pii 1701910 (2018). doi: 10.1183/13993003.01910-2017  

Kath, C., Mueller, R., Schultz, C., Haucke, V., Eickholt, B., Schmoranzer, J. PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules. PLoS One 13, e0193257 (2018). doi: 10.1371/journal.pone.0193257.

Hauke, S., Keutler, K., Yushchenko, D., Schultz, C. Endogenous Fatty Acids are Essential Autocrine Signaling Factors of Pancreatic β-Cells and Insulin Secretion. Diabetes 67, (2018). doi.org/10.2337/db17-1215

Hoffmann, J.-E., Dziuba, D., Stein, F., Schultz, C. A bifunctional noncanonical amino acid: synthesis, expression and residue-specific proteome-wide incorporation. Biochemistry (2018). In press

Bogdanova, Y. A., Schultz, C., Belousov, V. V. Local Generation and Imaging of Hydrogen Peroxide in Living Cells. Curr. Protocols Chem. Biol. 9, 117-127 (2017).

Frank, J., Broichhagen, J., Yushchenko, D., Trauner, D.,  Schultz, C., Hodson, D. Optical tools for understanding the complexity of beta cell signaling and insulin release. Nat. Rev. Endocrinol. (2018) accepted

Laguerre A, Schultz C. Novel lipid tools and probes for biological investigations. Curr Opin Cell Biol. 2018 Aug;53:97-104. doi: 10.1016/j.ceb.2018.06.013. Epub 2018 Jul 14. Review. PubMed PMID: 30015291

Kirby, I. T., Kojic, A., Arnold, M. R., Thorsell, A.-G., Karlberg, T., Vermehren-Schmaedick, A., Sreenivasan, R., Schultz, C., Schüler, H., Cohen M. S.  A potent and selective PARP11 inhibitor suggests coupling between cellular localization and catalytic activity. Cell Chem. Biol. (2018). accepted

Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S, Belaaouaj A, Dalpke AH, Schultz C, Mall MA. Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease. Am J Respir Crit Care Med. 2014 May 1;189(9):1082-92. doi: 10.1164/rccm.201311-1932OC. PubMed PMID: 24678594

Infield DT, Matulef K, Galpin JD, Lam K, Tajkhorshid E, Ahern CA, Valiyaveetil FI. Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor. Nat Commun. 2018 Nov 29;9(1):5055. doi: 10.1038/s41467-018-07477-3. PubMed PMID: 30498243.

Kratochvil HT, Maj M, Matulef K, Annen AW, Ostmeyer J, Perozo E, Roux B, Valiyaveetil FI, Zanni MT. Probing the Effects of Gating on the Ion Occupancy of the K(+) Channel Selectivity Filter Using Two-Dimensional Infrared Spectroscopy. J Am Chem Soc. 2017 Jul 5;139(26):8837-8845. doi: 10.1021/jacs.7b01594. Epub 2017 May 12. PubMed PMID: 28472884

Valiyaveetil FI. A glimpse into the C-type-inactivated state for a Potassium Channel. Nat Struct Mol Biol. 2017 Oct 5;24(10):787-788. doi: 10.1038/nsmb.3480. PubMed PMID: 28981075

Matulef K, Valiyaveetil FI. Patch-Clamp Recordings of the KcsA K(+) Channel in Unilamellar Blisters. Methods Mol Biol. 2018;1684:181-191. doi: 10.1007/978-1-4939-7362-0_14. PubMed PMID: 29058192

Riederer EA, Focke PJ, Georgieva ER, Akyuz N, Matulef K, Borbat PP, Freed JH, Blanchard SC, Boudker O, Valiyaveetil FI. A facile approach for the in vitro assembly of multimeric membrane transport proteins. Elife. 2018 Jun 11;7. pii: e36478. doi: 10.7554/eLife.36478. PubMed PMID: 29889023

Jiang M, Yan Y, Yang K, Liu Z, Qi J, Zhou H, Qian N, Zhou Q, Wang T, Xu X, Xiao X, Deng L. Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis. J Cell Mol Med. 2018 Nov 20. doi: 10.1111/jcmm.14024. [Epub ahead of print] PubMed PMID: 30461194.

Li, B. X.;* Chen, J.; Chao, B.; David, L; Xiao, X. "A lamin-binding ligand LBL1 targets nuclear lamins", ACS Chem. Biol., 2018, 13, 1380-1387. 

Li, B. X.;* Chen, J.;Chao, B.;Zheng, Y.;Xiao, X.* "A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks" ACS Cent. Sci. 2018, DOI: 10.1021/acscentsci.8b00379

Sanford-Crane, H.; Pejovic, T.; Xiao, X. "Drugging Homologous Recombination: Back to the Future" Future Medicinal Chemistry, 2018, 10, 1279-1281.

Meng, Q.;Li, B. X.; Xiao, X. "Towards Developing Chemical Modulators of Hsp60 as Potential Therapeutics" Front. Mol. Biosci., 2018, doi: 10.3389/fmolb.2018.00035.