Current Lab Members


Paul Spellman Paul Spellman

 Professor

 

 

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Dmitri Rozanov 

Research Assistant Professor

Dmitri is working on single-cell sequencing of patient-derived tumor cells to understand how breast cancer heterogeneity plays a role in the metastatic potential and drug resistance. In addition, working on a project to identify tumor-specific T cell receptor sequences in order to design means for earlier detection of breast cancer.

 

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Myron Peto

Senior Research Associate

Myron works on construction and maintenance of pipelines specific to mutation calling.

 

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Pavana Anur

Research Associate

Pavana works on pipelines related to analysis of TCGA and ICGC data.

 

Kami Chiotti

Kami Chiotti  

Research Associate

Kami is a Bioinformatics Research Associate primarily focused on customization and implementation of algorithms for analysis of multidimensional "omics" data. With a particular interest in transcriptomics, she works to identify tumor-specific gene targets for immunologic and/or pharmacologic therapies. She also assists with development and containerization of computational pipelines designed for high-throughput DNA or RNA sequence analysis of a variety of features, such as mutation timing, copy number variants, structural aberrations, cluster analysis, and alternative splicing events.


Carol HalseyCarol Halsey

Research Assistant

Carol is interested in understanding the heterogeneity of breast cancer tumors at the single cell level through the use of Flow Cytometry, Cytof (Mass Cytometry), and single cell RNA sequencing. These approaches have the power to show different populations of cancer cells within a tumor. Carol also manages the regulatory compliance for the group in regards to human subjects research projects.

 

 

Chris BonifaceChristopher Boniface

 Lab Manager, Senior Research Assistant, Next Generation Sequencing Specialist

Chris has been with Dr. Paul Spellman's research laboratory at OHSU since 2013 and formally managed the lab since 2015. He specializes in the identification of tumor-derived mutations in blood samples using next-generation sequencing of cell free DNA. He has developed custom error-correction techniques that enable the accurate detection of known and de novo mutations present in only one in 10,000-100,000 molecules (0.01%-0.001% variant allele frequency). These methods to detect rare variants in blood from cancer patients provide a promising means for the early detection of recurrence as well as the identification of genetic alterations derived from metastases invisible to standard imaging technologies. The longitudinal study of cell free DNA may provide many other valuable insights into the course of a patient's disease as well. Chris currently works on research projects that use his methods to understand the clonal dynamics of tumor evolution, predict responses to therapy, and uncover genetic mechanisms of therapeutic resistance.

  

 
Taylor Kelley

Taylor Kelley 

 Research Assistant 



Asia Mitchell

 Asia Mitchell

 PhD Candidate

Asia studies clear-cell renal cell carcinomas from individuals with VHL syndrome. In performing whole-genome and exome sequencing across more than 150 synchronous renal carcinomas, our lab has identified several observations providing insight into tumor evolution (Fei et al. Nature Communications, 2016). Above all, our work demonstrates that synchronous renal carcinomas (From VHL Syndrome patients) are an under-utilized and promising biological system for probing tumor evolution.


Michael Heskett

PhD Candidate



Rick RollinsRick Rollins

Graduate Student

Rick's interest is in characterizing the epigenetic changes in breast cancer - the hope being to facilitate early detection and bolster patients' therapeutic response.


Matthew Parson Matthew Parson






Casey Conrad

Casey Conrad

 Executive Specialist