O'Roak Lab News

NIMH new innovator award recognizes leader in autism research

The National Institutes of Mental Health has awarded a highly competitive research grant to Brian J. O’Roak, Ph.D., assistant professor of molecular and medical genetics in the OHSU School of Medicine. Read More http://www.ohsu.edu/blogs/researchnews/2017/11/13/nimh-new-innovator-award-recognizes-leader-in-autism-research/

Sizeable fraction of autism risk traced to ‘mosaic’ mutations


The findings suggest that these so-called ‘mosaic mutations’ play a bigger role in autism than previously thought. “This number places mosaic mutations as a whole as having a similar contribution as other classes of de novo mutations,” says lead investigator Brian O’Roak... Read More https://spectrumnews.org/news/sizeable-fraction-autism-risk-traced-mosaic-mutations/?utm_source=Copy+of+Spectrum+News+%28Daily+Report%29&utm_campaign=022047ea09-EMAIL_CAMPAIGN_2017_09_13&utm_medium=email&utm_term=0_5d6f652fd5-022047ea09-168425737

Read the most recent O'Roak Lab publication!


Exonic Mosaic Mutations Contribute Risk for Autism Spectrum Disorder, published in September's issue of the American Journal of Human Genetics... Read More 


New Genetic Risk Factor for Autism Spectrum Disorder Identified


NEW YORK (GenomeWeb) – An international team led by Oregon Health and Science University researchers has identified new genetic risk factors for developing autism spectrum disorder (ASD). They noted that a small percentage of gene mutations in parents can lead to an extremely high frequency of genetic mutations that cause ASD in children... Read More https://www.genomeweb.com/genetic-research/new-genetic-risk-factor-autism-spectrum-disorder-identified

FOX 12 News: OHSU joins nation's largest autism study

“You can imagine a hundred families from across the country who all find out their children have autism for the same reason, having them be able to talk to each other and connect with each other,” O’Roak said.… Read More

Webinar: Brian O’Roak discusses the accelerating pace of autism genetics

On 27 April, Brian O’Roak described new strategies for identifying and validating autism risk genes. He also discussed how high-confidence risk genes are giving researchers a better understanding of autism.… Read More

KATU Channel 2 News: Families needed as OHSU researchers join largest autism study in history

"There's the big potential benefit we can make for individuals with autism and their families by learning more about the condition and the biology," Dr. Brian O'Roak, an assistant professor of molecular and medical genetics at OHSU said.…” Read More

OHSU researchers join SPARK, nation’s largest autism research study

Drs. Eric Fombonne, Brian O'Roak and Lark Huang-Storms aim to accelerate autism research and speed discovery of treatments.… Read More

Rising star: Brian O’Roak brings ‘A’ game to autism genetics

Brian O’Roak is rarely seen without a baseball cap. As a postdoctoral researcher, he was known for being intense and focused, sometimes responding to questions with a raised eyebrow beneath the bill of the cap, along with a noncommittal “Hmm …” Read More
OHSU neurogeneticist Brian J. O'Roak, Ph.D., is one of a select group of researchers in the United States and Canada to be honored with a 2015 Alfred P. Sloan Research Fellowship. The highly sought-after award honors early-career scientists whose achievements and potential identify them as "rising stars."... Read More
A second look at 64 genes implicated in autism has bolstered evidence for the strongest candidates and renewed interest in others with more modest ties to the disorder. The approach, described 24 November in Nature Communications, will help researchers reconcile the reams of data emerging from large sequencing studies....Read More
A new study out of Oregon Health And Sciences University has identified 27 genes that, if mutated, may cause autism....Read More
Analyzing the sequences of more than 20,000 people, researchers have unearthed the largest and most robust list of autism genes so far, they reported today in Nature....Read More