Publications
Selected publications
Ultrafiltered recombinant AAV8 vector can be safely administered in vivo and efficiently transduces liver.
Kleven MD, Gomes MM, Wortham AM, Enns CA, Kahl CA. PLoS One. 2018 Apr 5;13(4):e0194728. doi: 10.1371/journal.pone.0194728. eCollection 2018. PMID: 29621273
Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms.
Kleven MD, Jue S, Enns CA. Biochemistry. 2018 Mar 6;57(9):1552-1559. doi: 10.1021/acs.biochem.8b00006. Epub 2018 Feb 12. PMID: 29388418
The Tumor Suppressor, P53, Decreases the Metal Transporter, ZIP14.
Zhao N, Zhang AS, Wortham AM, Jue S, Knutson MD, Enns CA. Nutrients. 2017 Dec 8;9(12). pii: E1335. doi: 10.3390/nu9121335. PMID: 29292794
Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway.
Wahedi M, Wortham AM, Kleven MD, Zhao N, Jue S, Enns CA, Zhang AS. J Biol Chem. 2017 Nov 3;292(44):18354-18371. doi: 10.1074/jbc.M117.801795. Epub 2017 Sep 18. PMID: 28924039
Versatile Interacting Peptide (VIP) Tags for Labeling Proteins with Bright Chemical Reporters.
Zane HK, Doh JK, Enns CA, Beatty KE. Chembiochem. 2017 Mar 2;18(5):470-474. doi: 10.1002/cbic.201600627. Epub 2017 Jan 25. PMID: 28052473
Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia.
Tuschl K, Meyer E, Valdivia LE, Zhao N, Dadswell C, Abdul-Sada A, Hung CY, Simpson MA, Chong WK, Jacques TS, Woltjer RL, Eaton S, Gregory A, Sanford L, Kara E, Houlden H, Cuno SM, Prokisch H, Valletta L, Tiranti V, Younis R, Maher ER, Spencer J, Straatman-Iwanowska A, Gissen P, Selim LA, Pintos-Morell G, Coroleu-Lletget W, Mohammad SS, Yoganathan S, Dale RC, Thomas M, Rihel J, Bodamer OA, Enns CA, Hayflick SJ, Clayton PT, Mills PB, Kurian MA, Wilson SW. Nat Commun. 2016 May 27;7:11601. doi: 10.1038/ncomms11601. PMID: 27231142
Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.
Zhao N, Maxson JE, Zhang RH, Wahedi M, Enns CA, Zhang AS. J Biol Chem. 2016 Jun 3;291(23):12322-35. doi: 10.1074/jbc.M116.721191. Epub 2016 Apr 12. PMID: 27072365 Free PMC Article
Bone Morphogenetic Protein-6 Mutations Take Their Place in Iron Overload Diseases.
Kleven MD, Enns CA, Zhang AS. Gastroenterology. 2016 Mar;150(3):556-9. doi: 10.1053/j.gastro.2016.01.016. Epub 2016 Jan 25. No abstract available. PMID: 26820052
CD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression.
Chen J, Enns CA. J Biol Chem. 2015 Mar 20;290(12):7841-50. doi: 10.1074/jbc.M114.632778. Epub 2015 Jan 29. PMID: 25635054
Low intracellular iron increases the stability of matriptase-2.
Zhao N, Nizzi CP, Anderson SA, Wang J, Ueno A, Tsukamoto H, Eisenstein RS, Enns CA, Zhang AS. J Biol Chem. 2015 Feb 13;290(7):4432-46. doi: 10.1074/jbc.M114.611913. Epub 2014 Dec 30. PMID: 25550162
An iron-regulated and glycosylation-dependent proteasomal degradation pathway for the plasma membrane metal transporter ZIP14.
Zhao N, Zhang AS, Worthen C, Knutson MD, Enns CA. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9175-80. doi: 10.1073/pnas.1405355111. Epub 2014 Jun 9. PMID: 24927598
The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body.
Worthen CA, Enns CA. Front Pharmacol. 2014 Mar 6;5:34. doi: 10.3389/fphar.2014.00034. eCollection 2014. Review. PMID: 24639653
The first transmembrane domain of lipid phosphatase SAC1 promotes Golgi localization.
Wang J, Chen J, Enns CA, Mayinger P. PLoS One. 2013 Aug 1;8(8):e71112. doi: 10.1371/journal.pone.0071112. Print 2013. PMID: 23936490
Iron regulation by hepcidin.
Zhao N, Zhang AS, Enns CA. J Clin Invest. 2013 Jun;123(6):2337-43. doi: 10.1172/JCI67225. Epub 2013 Jun 3. PMID: 23722909
Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway.
Enns CA, Ahmed R, Wang J, Ueno A, Worthen C, Tsukamoto H, Zhang AS. PLoS One. 2013;8(4):e60534. doi: 10.1371/journal.pone.0060534. Epub 2013 Apr 2. PMID: 23565256
N-linked glycosylation is required for transferrin-induced stabilization of transferrin receptor 2, but not for transferrin binding or trafficking to the cell surface.
Zhao N, Enns CA. Biochemistry. 2013 May 14;52(19):3310-9. doi: 10.1021/bi4000063. Epub 2013 Apr 30. PMID: 23556518
Iron transport machinery of human cells: players and their interactions.
Zhao N, Enns CA. Curr Top Membr. 2012;69:67-93. doi: 10.1016/B978-0-12-394390-3.00003-3. Review. PMID: 23046647
Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage.
Enns CA, Ahmed R, Zhang AS. J Biol Chem. 2012 Oct 12;287(42):35104-17. doi: 10.1074/jbc.M112.363937. Epub 2012 Aug 14. PMID: 22893705
Hereditary hemochromatosis and transferrin receptor 2.
Chen J, Enns CA. Biochim Biophys Acta. 2012 Mar;1820(3):256-63. doi: 10.1016/j.bbagen.2011.07.015. Epub 2011 Aug 16. Review. PMID: 21864651
Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein.
Zhang AS, Anderson SA, Wang J, Yang F, DeMaster K, Ahmed R, Nizzi CP, Eisenstein RS, Tsukamoto H, Enns CA. Blood. 2011 Feb 3;117(5):1687-99. doi: 10.1182/blood-2010-06-287292. Epub 2010 Nov 29. PMID: 21115976
Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression.
Maxson JE, Chen J, Enns CA, Zhang AS. J Biol Chem. 2010 Dec 10;285(50):39021-8. doi: 10.1074/jbc.M110.183160. Epub 2010 Oct 11. PMID: 20937842
ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin.
Zhao N, Gao J, Enns CA, Knutson MD. J Biol Chem. 2010 Oct 15;285(42):32141-50. doi: 10.1074/jbc.M110.143248. Epub 2010 Aug 3. PMID: 20682781
The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo.
Zhang AS, Gao J, Koeberl DD, Enns CA. J Biol Chem. 2010 May 28;285(22):16416-23. doi: 10.1074/jbc.M110.109488. Epub 2010 Apr 2. PMID: 20363739
Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice.
Gao J, Chen J, De Domenico I, Koeller DM, Harding CO, Fleming RE, Koeberl DD, Enns CA. Blood. 2010 Apr 22;115(16):3374-81. doi: 10.1182/blood-2009-09-245209. Epub 2010 Feb 22. PMID: 20177050