A basic science department examining cell-intrinsic and cell-extrinsic regulation of cell, developmental and cancer biology. READ ABOUT US.
WelcomeThe overarching mission of the OHSU Department of Cell, Developmental & Cancer Biology is to advance the understanding of problems relevant to human health and disease. To accomplish this mission, research groups in the department have historically focused on questions regarding cell structure, organelles, life cycle, differentiation, and regulated communication between cells and extracellular signals and cues. An ultimate application of knowledge gained from these studies has been to understand important cell physiologic processes that effect human biology. These issues directly link to problems of interest to developmental biologists, including molecular and cellular mechanisms regulating tissue morphogenesis, tissue polarity and patterning. Read more
News and Recognitions
Recent CDCB publications:
Moran Lab published Late stage tumor regression after PD-L1 blockade with a concurrent OX40 agonist.
Congratulations to Philip Copenhaver, Ph.D., on his new grant, Normal and abnormal control of APP signaling.
OHSU Foundation's Onward campaign recently featured three CDCB faculty members, Sudarshan Anand, Ph.D., Amy Moran, Ph.D. and Naoki Oshimori, Ph.D., in the article Chasing Down Cancer.
Recent CDCB and Knight Cancer publications:
Lund Lab published IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin. The article was highlighted here in Nature Reviews Cancer.
Tyner Lab and Knight Cancer Institute collaborators published CSF1R inhibitors exhibit anti-tumor activity in acute myeloid leukemia by blocking paracrine signals from support cells.
Beer and Qian Lab published Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy.
Congratulations to Lisa Coussens, Ph.D., honored by the American Association for the Advancement of Science as an elected AAAS Fellow for her pioneering studies in tumor biology.
Cancer Translated News: Study explains a tumor enabling role of the immune system – and suggests a new treatment approach.
Recent CDCB publications:
Wong Lab published Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival.
Coussens Lab published Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy.
OHSU News: Tumor cells fuse with immune cells and become more aggressive. Download the featured published article here.
Congratulations to Lisa Coussens, Ph.D., recipient of the 2018 Brinker Award for Scientific Distinction in Basic Science.
Congratulations to Sudarshan Anand, Ph.D., on his NHLB award for A microRNA-target Network in Endothelial DNA Damage and Angiogenesis and a second NHLB award for MicroRNA regulation of endothelial DNA repair to enhance anti-tumor immunity.
View all CDCB news and recognitions.