Genome science research within OCSSB is focused on two primary areas of interest. First, we are working on the development of new methods and computational approaches to connect the normal and aberrant function of genes with the architectural features of cells and tissues. To do this, we use the suite of multiscale imaging modalities available within the OCSSB in conjunction with spatially resolved targeted and whole exome sequencing.
In addition, we are actively working on the development of genomics assays and analytical techniques to improve precision medicine. In collaboration with the SMMART treatments program, we are performing longitudinal genomic profiling of biopsies from late-stage cancer patients in order to understand the role genetic alterations play in the development of therapeutic resistance. We are also working with the Spellman Lab and the Knight Diagnostics Lab to monitor and profile the circulating tumor DNA (ctDNA) in these patients in order to assess therapeutic response, monitor minimum residual disease, and predict progression. This work involves the active development of new assays to sensitively measure ctDNA burden and new computational methods to understand the patterns of clonal evolution.
Please direct any inquiries regarding collaboration on genomics projects to Brett Johnson.