OCSSB Seminar: "Mechanistic Basis of Gene Editing and Multidrug Resistance Revealed by CryoEM"
Tuesday, March 19, 2019, 12 to 1 p.m. at Vollum Institute M1441
Min Luo, Ph.D., Postdoctoral Fellow, Harvard Medical School, will be presenting. In this seminar, single particle cryoEM is applied to 1) study the function mechanism of CRISPR-Cas system, and 2) obtain high resolution drug binding information for human P-glycoprotein (Pgp). CRISPR-Cas systems are RNA-based adaptive immune systems found in prokaryotes, and nowadays widely employed for gene editing purpose. Using cryoEM, I determined several high resolution structure snapshots of Type 1 CRISPR enzymes in the process of foreign DNA targeting and degradation, and characterized the structure-function of the key molecular events leading to the onset of CRISPR interference. Pgp is a key player in multidrug resistance (MDR) in cancer, yet its underlying multidrug translocation mechanism and efficient inhibition strategies are still unknown. I have recently determined a structure of human Pgp bound to an anti-cancer drug, and further identified two distinct inhibition mechanisms. These results will provide crucial information in drug design targeting human Pgp to combat multidrug resistance. Contact Lauren Kronebusch for more information. Hosted by the OCSSB.
M2CH Center for Cancer Systems Biology MathOnc Workshop
May 13-14, 2019 at the Knight Cancer Research Building Auditorium
A special multi-day hands-on workshop to bring together the mathematical and computational cancer modelers within both the Cancer Systems Biology Consortium (CSBC) and Physical Sciences - Oncology Network (PS-ON) programs and key individuals from the broader mathematical oncology community. This meeting will be co-chaired by Alexander (Sandy) Anderson (Moffitt), Claire Tomlin (Berkeley) and Kristin Swanson (Mayo Clinic). With the increasing importance of mathematical models of cancer as a means to both better understand and treat the disease as well as integrate disparate data, there is a need to share our experience in developing, applying and integrating these models at the interface. Contact Lauren Kronebusch for more information. Hosted by the OCSSB M2CH Center for Cancer Systems Biology.
Past OCSSB-hosted seminar recordings are available online (Flash plugin required).