James Korkola

Jim Korkola

Phone: 503-494-4943
Fax: 503-494-3688

Current Appointment
Assistant Professor

Robertson Life Sciences Building (CLSB)
Mail Code: CL3G
2730 SW Moody Avenue, Portland, OR 97201

Ph.D., University of Toronto
Postdoctoral Fellow, University of California, San Francisco
Postdoctoral Fellow, Memorial Sloan-Kettering Cancer Center

Research Area
OHSU Center for Spatial Systems Biomedicine

Research Interests
The goal of Dr. Korkola’s cancer research is to identify novel therapeutic targets for intervention using informatics approaches on pre-existing data sets and to validate these experimentally.

Selected Publications

  • Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z. (2012) The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression. Cancer Discovery, Jun 22 [Epub ahead of print].
  • Collisson, E.A., Trejo, C.L., Gu, S., Korkola, J.E., Heiser, L.M., Charles, R.P., Rabinovich, B.A., Hann, B., Dankort, D., Spellman, P.T., Philips, W.A., Gray, J.W., and McMahon, M. (2012) A Central role for RAF →MEK →ERK signaling in the genesis of pancreatic ductal adenocarcinoma. Cancer Discovery, May 24 [Epub ahead of print].
  • Heiser, L.M., Sadanandam, A., Kuo, W.L., Benz, S.C., Goldstein, T.C., Ng, S., Gibb, W.J., Wang, N.J., Ziyad, S., Tong, F., Bayani, N., Hu, Z., Billig, J.I., Dueregger, A., Lewis, S., Jakkula, L., Korkola, J.E., Durinck, S., Pepin, F., Guan, Y., Purdom, E., Neuvial, P., Bengtsson, H., Wood, K.W., Smith, P.G., Vassilev, L.T., Hennessy, B.T., Greshock, J., Bachman, K.E., Hardwicke, M.A., Park, J.W., Marton, L.J., Wolf, D.M., Collisson, E.A., Neve, R.M., Mills, G.B., Speed, T.P., Feiler, H.S., Wooster, R.F., Haussler, D., Stuart, J.M., Gray, J.W., Spellman, P.T. (2012) Subtype and pathway specific responses to anticancer compounds in breast cancer. Proc. Natl. Acad. Sci. USA. 109(8):2724-2729. PMC3286973.
  • The Cancer Genome Atlas Group (TCGA). (2011) Integrated genomic analyses of ovarian carcinoma. Nature, 474(7353):609-615. PMC3163504.
  • Korkola, J., Gray, J.W. (2010) Genetic and cellular mechanisms of oncogenesis, Breast cancer genomes — form and function. Curr. Opin. Genet. Dev., 20:4-14. PMC2956580.