MD/PhD Journal Club

Journal Club is a required course for all MD/PhD students and attendance is required. With a few exceptions including holidays, Journal Club is hosted every Wednesday from 12-1pm in MacKenzie Hall, room 2201. These presentations are open to the public.

Each MD/PhD student will present a journal article of their choosing 1-2 times each year throughout the entirety of their program. Students ready to defend may use their Journal Club presentation as a time to run through their dissertation. About once a month a faculty member will present at Journal Club as Faculty Grand Rounds. 

Review presentation guidelines

Upcoming Presentations

August 22
Continuous Glucose Monitoring and Insulin Informed Advisory System with Automated Titration and Dosing of Insulin Reduces Glucose Variability in Type 1 Diabetes Mellitus
Nichole Tyler
Read the article

August 29
Katy Michaelis

September 5
Amanda Lund, PhD, Assistant Professor, Cell, Developmental & Cancer Biology

September 12
No Journal Club: MD College Retreat off-campus
September


September 19
Sudarshan Iyer

September 26
Gina Calco

October

October 3
Allejandro Aballay, PhD, Professor & Chair, Molecular Microbiology & Immunology

October 10
TheAnh Nguyen

October 17
Rachel Drake

October 24
Michael Berry

October 31
Life After Residency
Dave Lewinsohn, MD, PhD, Professor, Pulmonary & Critical Care Medicine

November

November 7
Kristen Stevens

November 14
Jim Goodman

November 21
No Journal Club: Thanksgiving Holiday

November 28
Brennan Olson

December

December 5
Sunil Joshi

December 12
Samuel Huang

December 19
Negative crosstalks between hypoxia and androgen response pathways lead to therapy resistance in prostate cancer
David Qian, PhD, Assistant Professor, Knight Cancer Institute

December 26
No Journal Club: Winter Break

Past Presentations

2018


August 15
How to Present a Journal Club
David Jacoby, MD, Program Director, MD/PhD Program; Chair & Professor, Department of Medicine

August 8

Novel Insights into IL-33 Regulation in Allergic Disease
Marsha Wills-Karp, PhD, Chair & Professor, Environmental Health & Engineering, Johns Hopkins University
View Flier


August 1
CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning
Mollie Marr
Read the article

July 25
Allogenic Stem Cell Transplantation in HIV Cure
Jonah Sacha, PhD, Associate Professor, Vaccine and Gene Therapy Institute, Molecular Microbiology and Immunology, Oregon National Primate Research Center

July 18
Sexual Harassment of Women: Climate, Culture, and Consequences in Academic Sciences, Engineering, and Medicine
Kelsey Priest

Read Full Report: Sexual Harassment of Women: Climate, Culture, and Consequences in Academic Sciences, Engineering, and Medicine (2018)
Read Summary Article: Sexual harassment is rampant in science —and current policies aren't cutting it, landmark report finds

Physiological Changes During Long-Duration Space Flight
John Butler

Read Article 1: Fluid shifts, vasodilatation and ambulatory blood pressure reduction during long duration spaceflight
Read Article 2: Increased core body temperature in astronauts during long-duration space missions


June 20
A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action
Sweta Adhikary
Read the Article

June 13
Socioeconmic Outcomes of Women Who Receive and Women Who Are Denied Wanted Abortions in the United States
Caroline King
Read the Article

June 6
The Human Side of Data: Examining the intersection of data, integrity, and society
Jackie Wirz, PhD, Assistant Dean, School of Medicine Graduate Studies

May 30
1) Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
2) Human hippocampal neurogensis persists throughout aging

Kevin Burfeind
Read Article 1
Read Article 2

May 16
Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes
Cheryl Claunch
Read Article

May 9
Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair
Anjali Narayanan
Read Article
Read Commentary

May 2
Molecular and Genetic Mechanisms of Myelin Development and Repair
Kelly Monk, PhD, Senior Scientist & Co-Director, Vollum Institute

April 25

Pre and postnatal determinants of airway hyperreactivity
Katie Lebold

April 18

Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial . See article.
Cymon Kersch

April 11

Carsten Schultz, PhD, Professor, Physiology & Pharmacology

April 4

The fuzzy logic of network connectivity in mouse visual thalamus.  See article.
Ali Pincus

March 28

Using synthetic templates to design an unbiased multiplex PCR assay. See article.
Burcu Gurun-Demir

March 21

Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module. See article.
Gavin

March 14

Panel Discussion: Navigating the Unknown: Shared Decision-Making in the Face of Uncertainty in Science and Clinic
Jenya Zilberman-Rudenko

March 7

Modeling Anxiety in the Laboratory
Bita Moghaddam, PhD, Professor & Chair, Behavioral Neuroscience

February 28

Introduction to Dr. Cindy McEvoy, Retreat Keynote Speaker
Elizabeth Swanson

February 21

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice, https://www.ncbi.nlm.nih.gov/pubmed/26785494
Jackie Emathinger

February 7

Light: A window into pain in the brain
Dr. Mary Heinricher, Neurology

January 31

Accelerating bacterial growth detection and antimicrobial susceptibility assessment in integrated picoliter droplet platform, https://www.ncbi.nlm.nih.gov/pubmed/28609716
Tony Zheng

January 24

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(17)30472-1
Sam Huang

January 17

Stress-induced unfolded protein response contributes to Zika virus–associated microcephaly, https://www.ncbi.nlm.nih.gov/pubmed/29230053
Jim Goodman

January 10

Transcription Factor EB Controls Metabolic Flexibility during Exercise, https://www.ncbi.nlm.nih.gov/pubmed/28011087
Rachel Drake

January 3 

Molecular mechanisms of axon degeneration
Marc Freeman, PhD, Senior Scientist & Director, Vollum Institute

2017

Dec 20, Cheryl, 3D Collagen Architecture and vasculogenic mimicry,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698427/

Dec 13, Anjali, iNKT Cells Orchestrate a Switch from Inflammation to Resolution of Sterile Liver Injuryhttp://www.sciencedirect.com/science/article/pii/S1074761317304272 commentary  http://www.sciencedirect.com/science/article/pii/S1074761317304272

Dec 6, Dr. David Bangsberg, Dean School of Public Health, International perspectives on adherence to hiv prevention and treatment

November 29, Brennan, In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapyhttp://stm.sciencemag.org/content/scitransmed/9/389/eaal3604.full.pdf

November 15, Mike, Unique approaches to restoration of patterned vision using optogenetic gene therapy

November 8, Gina, Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR−/− mouse model of atherosclerosis, https://www.ncbi.nlm.nih.gov/pubmed/28899902

November 1, H. Scott Stadler, Skeletal Biology, Role of long non coding RNAs in cartilage and genitourinary development

October 25, TheAnh, Macrophages Facilitate Electrical Conduction in the Heart http://www.cell.com/fulltext/S0092-8674(17)30412-9

October 18, Kristen, Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements https://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3963.html#affil-auth

October 11, Katy, GFRAL and GDF15: roles in cachexia and obesity. Articles: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15, and GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

October 4, Dr. Agnieszka Balkowiec, Integrative Biosciences, Novel Approaches to Understanding Mechanisms of Craniofacial Pain: Focus on Proinflammatory Cytokines and Neurotrophic Factors

September 27, Sweta, Sufficiency of Mesolimbic Dopamine Neuron Stimulation for the Progression to Addiction  http://www.cell.com/neuron/pdfExtended/S0896-6273(15)00883-1

September 20, Kelsey, Protecting unauthorized immigrant mothers improves their children's mental health http://science.sciencemag.org/content/early/2017/08/30/science.aan5893/tab-pdf

September 13, Kevin B,  Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility http://www.sciencedirect.com.liboff.ohsu.edu/science/article/pii/S155041311730339X

September 6, Dr. Reid Thompson, Radiation Oncology, Cancer Immunotherapy Genomics

August 30, Dr. David Jacoby, Welcome new students, How to give a good journal club.

August 23, Sudarshan, BET Bromodomain Proteins Function as Master Transcription Elongation Fastors Independent of DCK9 Recruitment,https://www.ncbi.nlm.nih.gov/pubmed/28673542

August 16, Nichole, Fasting-Mimicking Diet Promotes Ngn3-Driven Β-Cell Regeneration to Reverse Diabetes http://www.sciencedirect.com/science/article/pii/S00923867417301307

August 9, John, Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER https://www.ncbi.nlm.nih.gov/pubmed/27114500

August 2, Cymon A soft robotic exosuit improves walking in patients after stroke http://stm.sciencemag.org/content/9/400/eaai9084/tab-pdf

July 26, Sunil, SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer,https://www.ncbi.nlm.nih.gov/pubmed/28059768

July 19, Mollie, Neural correlates of maintaining one's political beliefs in the face of counter evidence, https://www.nature.com/articles/srep39589

July 12, Tomo Ito and Matthew Rempes--Demystifying the MD lottery process  

June 21, Katie, Bumblebee family lineage survival is enhanced in high-quality landscapes http://www.nature.com/nature/journal/v543/n7646/abs/nature21709.html

June 14, Elizabeth, New Persistent Opioid Use After Minor and Major Surgical Procedures in US Adults, https://www.ncbi.nlm.nih.gov/pubmed/28403427

June 7, Dr. Steven Mansoor, Cardiology, How structural biology can impact cardiovascular medicine: P2X receptor from sequence to structure

May 31, Ali, History-dependent variability in population dynamics during evidence accumulation in cortex http://www.nature.com/neuro/journal/v19/n12/pdf/nn.4403.pdf

May 24, Jenya, A role for factor XIIa–mediated factor XI activation in thrombus formation in vivo. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981546/

May 17, TheAnh, Augmentation of Muscle Blood Flow by Ultrasound Cavitation Is Mediated by ATP and Purinergic Signaling https://www.ncbi.nlm.nih.gov/pubmed/28174191

May 10, Katy, S100-alarmin-induced innate immune programming protects newborn infants from sepsis  http://www.nature.com/ni/journal/vaop/ncurrent/full/ni.3745.html

May 3, Dr. Jim McCormick, Nephrology, Ubiquitin Ligase-mediated Regulation of Blood Pressure and Potassium Homeostasis

April 26, Dr. Honora Englander, Developing and Implementing Addiction Medicine Consultation (IMPACT) at OHSU

April 19, Rachel, Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation, https://www.ncbi.nlm.nih.gov/pubmed/28086092

April 12, Sam, Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568951/

April 5, Cheryl, Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression.  http://www.nature.com/ncb/journal/v18/n12/full/ncb3429.html

March 29, Andy, Danielle, Noah, Dominic Tales from the Residency Trail

March 22, Sweta, A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins  http://www.cell.com/neuron/pdf/S0896-6273%2817%2930010-7.pdf

March 15, Gina, Disrupted iron regulation in the brain and periphery in cocaine addiction https://www.ncbi.nlm.nih.gov/pubmed/28221362

March 8, Mike, How Azobenzene Photoswitches Restore Visual Responses to the Blind Retinahttp://www.sciencedirect.com/science/article/pii/S0896627316305311

March 1, Dr. Julia Maxson, Hematology and Medical Oncology, Genomically guided targeted therapeutics in myeloid leukemia

February 22, Brennan, CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells http://www.nature.com/nature/journal/v539/n7629/full/nature20134.html

February 15, Kelsey Methadone continuation versus forced withdrawal on incarceration in a combined US prison and jail: a randomised, open-label trial. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522212/

February 8, Jim, Gamma frequency entrainment attenuates amyloid load and modifies microglia http://www.nature.com/nature/journal/v540/n7632/full/nature20587.html

February 1, Dr. Amanda McCullough, Oregon Institute of Occupational Health Sciences, DNA Repair Strategies for Prevention and Treatment of Cancer

January 25, Kevin B. Origin, fate, and dynamics of macrophages at central nervous system interfaces http://www.nature.com/ni/journal/v17/n7/full/ni.3423.html

January 18, Anjali, Epigenetic Modification and Antibody-Dependent Expansion of Memory-like NK Cells in Human Cytomegalovirus-Infected Individuals https://www.ncbi.nlm.nih.gov/pubmed/25786175

January 4, Dr. Richard Mullins, Trauma Surgery, Development of the Starr Edwards prosthetic heart valves  http://www.ohsu.edu/xd/education/schools/school-of-medicine/departments/clinical-departments/surgery/richard-mullins-retires.cfm 

2016

December 14, Zach, Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016169/

December 7, Dr. Shannon McWeeney, DMICE, Reproducibility or Bust: What Everyone Needs to Know and Do

November 30, Kristen, Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder. https://www.ncbi.nlm.nih.gov/pubmed/27479844

November 16, Sunil, Improved i.p. drug delivery with bioadhesive nanoparticles https://www.ncbi.nlm.nih.gov/pubmed/27663731

November 9, Nichole, Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein http://www.nature.com/articles/ncomms12808 And an associated news article about it: http://www.nature.com/news/tardigrade-protein-helps-human-dna-withstand-radiation-1.20648

October 26, Jenya, Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. https://www.ncbi.nlm.nih.gov/pubmed/2202907

October 19, Mollie, Do Early Educators' Implicit Biases Regarding Sex and Race Relate to Behavior Expectations and Recommendations of Preschool Expulsions and Suspensions? http://ziglercenter.yale.edu/publications/Preschool%20Implicit%20Bias%20Policy%20Brief_final_9_26_276766_5379.pdf

October 12, Elizabeth,Targeted Fibrillar Nanocarbon RNAi Treatment of Acute Kidney Injury  https://www.ncbi.nlm.nih.gov/pubmed/27009268

October 5, Dr. Miranda Lim, Pulmonary & Critical Care, The role of sleep in the pathogenesis of autism spectrum disorder: Lessons from the social prairie vole

September 28, Sudarshan, Stimulating the RIG-I pathway to kill cells in the latent HIV reservoir following viral reactivation http://www.nature.com/nm/journal/v22/n7/full/nm.4124.html

September 21, John, The Rel/NF-κB pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity. http://www.ncbi.nlm.nih.gov/pubmed/22750545

September 14, Zip, Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy http://stm.sciencemag.org/content/scitransmed/8/351/351ra105.full.pdf

September 7, Kevin, Chronic administration of an HDAC inhibitor treats both neurological and systemic Niemann-Pick type C disease in a mouse model

http://stm.sciencemag.org/content/8/326/326ra23.abstract

August 31, MD/PhD Orientation, David Jacoby--How to give a journal club

August 24, Katie, Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children, http://www.nejm.org/doi/full/10.1056/NEJMoa1508749

August 17, Cymon, Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer, http://www.nature.com/nature/journal/v533/n7604/full/nature18268.html

August 10, Jim, Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature http://science.sciencemag.org/content/352/6291/1341.long

August 3, Dr. Sophia Bornstein, Radiation Oncology, Novel prognostic and predictive strategies in head and neck and lung cancer

July 27, Ali Sex Differences in Physician Salary in US Public Medical Schoolshttp://www.ncbi.nlm.nih.gov/pubmed/27400435

July 20, Rachel, Asprosin, a Fasting-Induced Glucogenic Protein Hormone, http://www.ncbi.nlm.nih.gov/pubmed/27087445

July 13, Sam, Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups.http://www.ncbi.nlm.nih.gov/pubmed/27151457

July 6, Cheryl, Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2016172a.html

June 29, Jenya, FXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flow http://www.bloodjournal.org/content/bloodjournal/126/12/1494.full.pdf

June 22, Katy, Daily co-trimoxazole prophylaxis to prevent mortality in children with complicated severe acute malnutrition: a multicentre, double-blind, randomised placebo-controlled trial http://www.thelancet.com/journals/langlo/article/PIIS2214-109X(16)30096-1/fulltext

June 15, Devon, Dissertation presentation: Scaffold-free tissue engineering for articular cartilage repair

June 8, Anjali, Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression http://www.cell.com/immunity/fulltext/S1074-7613(16)00030-3

June 1, Dr. Pepper Schedin, Cell & Developmental Biology, Pregnancy Related Breast Cancer Metastasis

May 25, Nathalie, Two related articles: Description Of Two Mouse Models Of Placental Zika Virus Infection http://www.cell.com/cell/fulltext/S0092-8674(16)30556-6 How IFNgamma1 May Protect Placental Trophoblasts From Zika Virus Infection http://www.sciencedirect.com/science/article/pii/S1931312816301007

May 18, Johanna, Challenging Questions

May 11, Kevin B. Myeloid cell transmigration across the CNS vasculature triggers IL-1β–driven neuroinflammation during autoimmune encephalomyelitis in mice http://jem.rupress.org/content/early/2016/04/26/jem.20151437.full

April 27, Q, On sensitization of a brainstem pain-modulating circuit during persistent pain.

April 20, Elizabeth,TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma. http://www.ncbi.nlm.nih.gov/pubmed/25723170

April 13, Dr. Raymond Bergan, Hematology/Oncology, Therapeutically Targeting Cancer Cell Motility

April 6, Zach, Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease http://www.nature.com/nm/journal/v22/n2/full/nm.4027.html

March 30, Sunil, Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565731/

March 23, Kelsey, Emergency Department–Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence: A Randomized Clinical Trial http://jama.jamanetwork.com/article.aspx?articleid=2279713

March 16, Nichole, Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes, http://www.nature.com/ncomms/2015/150407/ncomms7748/full/ncomms7748.html

March 9, Zip, Mastering the game of Go with deep neural networks and tree searchhttp://www.nature.com/nature/journal/v529/n7587/full/nature16961.html

March 2, Dr. Molly Kulesz-Martin, Dermatology, Precision medicine approaches in dermatology: squamous cell carcinoma and inflammation

February 24, Mollie,The Dissociative Subtype of Posttraumatic Stress Disorder: Unique Resting-State Functional Connectivity of Basolateral and Centromedial Amygdala Complexes http://www.nature.com/npp/journal/v40/n10/full/npp201579a.html

February 17, Sudarshan, Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein http://www.cell.com/cancer-cell/abstract/S1535-6108(15)00334-7

February 10, Dr. Nathalie Pamir, Research Assistant Professor, Knight Cardiovascular Institute, Is there something else to HDL than HDL cholesterol?

February 3, Charlie, Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease http://www.nature.com/nm/journal/v21/n9/full/nm.3901.html

January 27, Kevin K, Rescuing US biomedical research from its systemic flaws http://www.pnas.org/content/111/16/5773

January 20, John, Translating dosage compensation to trisomy 21 http://www.nature.com/nature/journal/v500/n7462/full/nature12394.html

January 13, Kristen, Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder, http://www.sciencemag.org.liboff.ohsu.edu/content/early/2015/12/29/science.aad7977.long Additional related articles: Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans, http://www.sciencedirect.com.liboff.ohsu.edu/science/article/pii/S1550413115005719     Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals, http://www.sciencemag.org.liboff.ohsu.edu/content/early/2015/12/29/science.aad6780.long

January 6, Dr. Monica Hinds, Biomedical Engineering, Bioactive biomaterials for cardiovascular applications

 

2015

December 16, Cymon, Two articles Structural and functional features of central nervous system lymphatic vessels Article: http://www.nature.com/nature/journal/v523/n7560/full/nature14432.html and A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.http://jem.rupress.org.liboff.ohsu.edu/content/212/7/991.long

December 9, Ali, Human mutant huntingtin disrupts vocal learning in transgenic songbirdshttp://www.nature.com/neuro/journal/v18/n11/pdf/nn.4133.pdf

December 2, Dr. Michael Cohen, Physiology & Pharmacology,Decoding Protein ADP-ribosylation Networks in Cells Using Chemical Genetic Approaches

November 18, Cheryl, Tumour exosome integrins determine organotropic metastasis http://www.nature.com/nature/journal/vaop/ncurrent/abs/nature15756.html

November 11, Jim, An astrocyte-dependent mechanism for neuronal rhythmogenesis http://www.nature.com/neuro/journal/v18/n6/full/nn.4013.html

November 4, Dr. Summer Gibbs, Biomedical Engineering, Novel Fluorescent Contrast for Macroscopic and Microscopic Cancer Imaging

October 28, Katie L. The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4. http://www.ncbi.nlm.nih.gov/pubmed/26424893

October 21, Nathalie, An ultrathin invisibility skin cloak for visible light  http://www.sciencemag.org/content/349/6254/1310.full

October 14, Devon, Identification of a Prg4-Expressing Articular Cartilage Progenitor Cell Population in Mice http://www.ncbi.nlm.nih.gov/pubmed/25603997

October 7, Dr. Garet Lahvis, Behavioral Neuroscience, Social Neuroscience: Social Mind, Emotional Mind, in Mice and Humans

September 30, Sam, CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes (Liang et al. 2015) http://link.springer.com/article/10.1007/s13238-015-0153-5

September 23, Rachel, Mitochondrial oxidative stress promotes atrial fibrillation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501003/

September 16, Anjali, The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways http://www.nature.com/ni/journal/v16/n7/full/ni.3196.html

September 9, Jenya,Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. http://www.ncbi.nlm.nih.gov/pubmed/23299850

September 2, Dr. Bonnie Nagel, Clinical Psychology, The chicken or the egg: Distinguishing between neurobiological markers of risk for versus consequences of adolescent drinking.

August 26, David Jacoby, Introductions and Presenting at Journal Club

August 19, Q, Nociceptive Sensitization Reduces Predation Risk, http://www.sciencedirect.com/science/article/pii/S0960982214003352

August 12, Zach, Matrix Metalloprotease 8-Dependent Extracellular Matrix Cleavage at the Blood–CSF Barrier Contributes to Lethality during Systemic Inflammatory Diseases http://www.jneurosci.org/content/32/29/9805.full.html

August 5, Katy M, Host microbiota constantly control maturation and function of microglia in the CNS http://www.nature.com/neuro/journal/v18/n7/full/nn.4030.html

July 29, Kevin B. Pharmacological chaperones stabilize retromer to limit APP processing  http://www.nature.com/nchembio/journal/v10/n6/full/nchembio.1508.html

July 22, cancelled

July 15, Elizabeth, Integrated compensatory network is activated in the absence of NCC phosphorylation http://www.jci.org/articles/view/78558

July 8, Derek, 100 years of General Relativity Theory, Article: http://www.sciencemag.org/content/347/6226/1103.fullExtra info http://www.sciencemag.org/content/347/6226.toc

July 1, no journal club.

June 24, Noah, An enigmatic plant-eating theropod from the Late Jurassic period of Chile, http://www.nature.com/nature/journal/v522/n7556/full/nature14307.html

June 17, Danielle, Propeptides and pH sensing in Proprotein Convertase 1/3

June 10, Residency Director's Panel, Dr Cindy Ferrell (Pediatrics), Dr. Karen Brasel (Surgery), Dr. Timur Mitin, Dr. Mark Wax, Otolaryngology

June 3, Dr. Sudarshan Anand, Cell and Developmental Biology, MicroRNA mediated inhibition of DNA repair as an anti-angiogenic strategy

May 27, Kelsey, The Oregon Experiment--Effects of Medicaid on Clinical Outcomes, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701298/

May 20, Greg, Rebecca and Garth: Tales from Residency Road

May 13, Charlie, A CXCL1 paracrine network links cancer chemoresistance and metastasis http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528019/pdf/nihms393624.pdf

May 6, Dr. Brian Johnstone, Orthopedics, Hypoxia inducible factors and cartilage regeneration

April 29, Cymon, Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988473/

April 22, Devon, Anticrack nucleation as triggering mechanism for snow slab avalanches http://www.sciencemag.org/content/321/5886/240

April 15, Dr. Peter Kurre, Stem Cell Center, Regulation of hematopoietic activity by "platelet dust"

April 8, Kevin K. Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution http://www.sciencemag.org/content/346/6208/1257998

April 1, Zip, Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack.  http://www.sciencedirect.com/science/article/pii/S1074761315000369

March 25, Jenya, Live-cell imaging of invasion and intravasation in an artificial microvessel platform, http://cancerres.aacrjournals.org/content/74/17/4937.long

March 18, Katie L. A new antibiotic kills pathogens without detectable resistance  http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14098.html

March 11, Cheryl, Cancer-Associated Protein Kinase C Mutations Reveal Kinase's Role as Tumor Suppressor http://www.cell.com/cell/abstract/S0092-8674(15)00002-1

March 4, Dr. Gail Mandel, Neuroscience, Recent Approaches For Understanding And Thinking About Cures For The Neurological Disease, Rett Syndrome

February 25, Anjali An ancient defense system eliminates unfit cells from developing tissues during cell competition URL:    http://www.sciencemag.org/content/346/6214/1258236.abstract

February 18, Ali, Microstructure of a spacial map in the entorhinal cortex. http://www.ncbi.nlm.nih.gov/pubmed/15965463

February 11, Julie, Identifying phenotypic signatures of neuropsychiatric disorders from electronic medical records, http://www.ncbi.nlm.nih.gov/pubmed/23956017

February 4, Sam, Perceptual relearning of complex visual motion after V1 damage in humans (Huxlin et al, 2009) http://www.ncbi.nlm.nih.gov/pubmed/19339594

January 28, Rachel, Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation, http://www.ncbi.nlm.nih.gov/pubmed/25564678

January 21, Jim, Foretinib is effective therapy for metastatic Sonic Hedgehog medulloblastoma http://cancerres.aacrjournals.org/content/early/2014/11/12/0008-5472.CAN-13-3629.long

January 14, Dr. Shannon McWeeney, Biostatistics and Bioinformatics, Data tells a Story: Visual and Statistical Thinking for Translational Study Designs

January 7, Nathalie, Tracking cancer drugs in living cells by thermal profiling of the proteomehttp://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=25278616

 

2014

December 17, Katy M. CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling http://www.sciencedirect.com/science/article/pii/S0092867414011635

December 10, Kristen, An enteric virus can replace the beneficial function of commensal bacteria, http://www.nature.com/nature/journal/v516/n7529/full/nature13960.html

December 3, Dr. Bill Rooney, Advanced Imaging Research Center, Quantitative Magnetic Resonance Imaging and Spectroscopy at High Magnetic Field: Insights into Cerebral Metabolism

November 19, Danielle, Life cycles, fitness decoupling and the evolution of multicellularity. http://www.nature.com/nature/journal/v515/n7525/full/nature13884.html

November 12, Derek Paleomagnetic and tephra evidence for tens of Missoula floods in southern Washington, http://geology.gsapubs.org/content/31/3/247.abstract

November 5, Dr. Larisa Tereshchenko, Cardiology, Risk stratification of sudden cardiac death in the general population of asymptomatic adults

October 29, Noah, The genetics of monarch butterfly migration and warning colouration, URL:   http://www.nature.com/nature/journal/v514/n7522/full/nature13812.html

October 22, Dr. Jamie Lee, Professor at Mayo Arizona, Fifty Shades of Eosin: The Hidden Role of Eosinophils in Bladder Cancer

October 15, Elizabeth, Pulmonary macrophage transplantation therapy URL: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13807.html

October 8, Dr.  Bill Chang,  Pediatric Hematology, Bill Chang's Road to Physician-Scientist.  Personalized pathway to personalized medicine

October 1, Q, Retreat Keynote Presentation: Modulation of natural killer cell antitumor activity by the aryl hydrocarbon receptor, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725066/

September 24, Kevin B. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 URL: http://www.nature.com/nature/journal/v508/n7496/full/nature13027.html

September 17, Johanna, Challenging Questions--Leadership development

September 10, Zach, Close-Field Electroporation Gene Delivery Using the Cochlear Implant Electrode Array Enhances the Bionic Ear http://stm.sciencemag.org/content/6/233/233ra54.abstract

September 3, David Jacoby, Orientation, program welcome

August 27, Jenya, Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts, URL: http://www.nature.com/nature/journal/v510/n7504/full/nature13233.html#figures

August 20, Charlie, Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes, http://www.pnas.org/content/107/50/21248.long

August 13, Katie L. Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility http://www.cell.com/abstract/S0092-8674(14)00735-1#

August 6, Dr. Jeff Gold, Director of Simulation Center,  A scientific approach to EHR usability

July 30, Cheryl, Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia". http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13528.html

July 23, Anjali, Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00175-5

July 16, Cymon, Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells, http://www.nature.com/ncomms/2014/140619/ncomms5196/pdf/ncomms5196.pdf

July 9, Zip, In Vivo–Generated Antigen-Specific Regulatory T Cells Treat Autoimmunity Without Compromising Antibacterial Immune Response http://m.stm.sciencemag.org/content/6/241/241ra78

June 25, QiLiang, Rapid 3D printing of anatomically accurate and mechanically heterogeneous aortic valve hydrogel scaffolds. http://www.ncbi.nlm.nih.gov/pubmed/22914604

June 18, Devon, TGF-β Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling  http://stm.sciencemag.org/content/6/227/227ra34.short

June 11, Kevin K. Autophagy regulates adipose mass and differentiation in mice http://jci.org/articles/view/39228

June 4, Dr. Scott Naugler, Gastroenterology, Why does the liver regenerate?

May 28, Residency Director's Panel: Dr. Alan Hunter, Internal Medicine; Dr. Mark Kinzie, Psychiatry; Dr. Cindy Ferrell, Pediatrics;  Dr. Paul Flint, Otolaryngology; Dr. Timur Mitin, Radiation Oncology; Dr. Sancy Leachman, Dermatology; Dr. Christopher Swide, Anesthesiology;

May 21, Jaime, Improving the Efficiency of Abdominal Aortic Aneurysm Wall Stress Computations

May 14, Julie, What Makes a Visualization Memorable? http://www.computer.org/csdl/trans/tg/2013/12/ttg2013122306-abs.html

May 7, 2014, Dr George Thomas, Pathology,  Targeted Therapies for Non-Clear Cell Kidney Cancer

April 30, Ted, et al, Residency Interview Trail

April 23, Danielle, High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation" http://www.nature.com/nature/journal/v504/n7480/full/nature12719.html

April 16, Dan, Avoiding Burnout, http://www.ncbi.nlm.nih.gov/pubmed/18765703 and http://www.ncbi.nlm.nih.gov/pubmed/?term=Vanquishing+Virtue%3A+Impact+of+Medical+Education

April 9, Zach, Stimulus-triggered fate conversion of somatic cells into pluripotency, http://www.nature.com/nature/journal/v505/n7485/full/nature12968.html

April 2, Dr. Miranda Lim, Sleep Medicine, Sleep disturbances after traumatic brain injury

March 26, Andy, Low dietary potassium directly activates the sodium chloride cotransporter to cause hypertensionhttp://www.nejm.org/doi/full/10.1056/NEJMra064486

March 19, Dominic, Munchausen syndrome: a novel cause of drug-resistant hypertension, http://www.ncbi.nlm.nih.gov/pubmed/23615324

March 12, Derek, In Situ Observations of Interstellar Plasma with Voyager 1 http://www.sciencemag.org/content/341/6153/1489.abstract

March 5, Dr. Fay Horak, Neurology, Physiology and Biomedical Engineering, Parkinson's disease:  Motor and Cognitive Locomotor Dysfunction

February 26, Katy M., Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans http://stm.sciencemag.org/content/5/209/209ra151

February 19, Elizabeth, XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity, http://www.ncbi.nlm.nih.gov/pubmed/23791175

February 12, Kristen, Neuronal Control of Metabolism through Nutrient-Dependent Modulation of Tracheal Branching http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898607/

February 5, Dr. David Jacoby, Mentorship

January 29, Kevin B. Imaging local neuronal activity by monitoring PO2 transients in capillaries URL: http://www.nature.com/nm/journal/v19/n2/full/nm.3059.html

January 22, Nathalie Differential DNA methylation regions in cytokine and transcription factor genomic loci associate with childhood physical aggression. URL:  http://www.ncbi.nlm.nih.gov/pubmed/23977113,  will also include http://www.ncbi.nlm.nih.gov/pubmed/23922720  and http://www.ncbi.nlm.nih.gov/pubmed/23115197  which are studies that lead up to this.

January 15, 2014, Dr. Shiuh-Wen Luoh, Knight Cancer Inst. Chromosome 17q11-12 amplification in breast cancer

January 8, Cymon, Targeting a Dual Detector of Skin and CO2 to Modify Mosquito Host Seeking http://www.sciencedirect.com.liboff.ohsu.edu/science/article/pii/S0092867413014268

 

2013

December 18
December 11

Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism. http://onlinelibrary.wiley.com/do/10.1111/acel.12153/full
Jenya

December 4

Brain Injury in the Premature Infant: Unexpected Mechanisms of Dysmaturation, Regeneration and Repair
Dr. Stephen Back, Pediatric Neuroscience

November 20, Anjali, Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1? and sterile vascular inflammation in atherosclerosis http://www.nature.com/ni/journal/v14/n10/full/ni.2704.html

November 13, Kevin K.,  Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation URL:  http://www.nature.com/ng/journal/v35/n3/full/ng1248.html

November 6, Dr. Sancy Leachman, Dermatology Melanoma Prevention Update

October 23, Devon High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat  http://www.nature.com/nature/journal/v499/n7458/full/nature12234.html

October 16, Cheryl, Nontoxic radioactive listeria is a highly effective therapy against metastatic pancreatic cancer, http://www.pnas.org/content/110/21/8668.long

October 9, Dr. Dan Marks, Pediatrics, Central Mechanisms in Cachexia

October 2, Derek, Effects of human eosinophil granule-derived cationic proteins on C-fiber afferents in the rat lung, http://m.jpa.physiology.org/content/91/3/1318.full.pdf

September 25, Charlie Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-Like Behaviorhttp://www.jneurosci.org.liboff.ohsu.edu/content/33/34/13820.long

September 18, Katie L.,  Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells http://www.ncbi.nlm.nih.gov/pubmed/?term=23921130

September 11, Zip, Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells http://stm.sciencemag.org.liboff.ohsu.edu/content/5/200/200ra116.short

September 4, Dr. David Jacoby, Welcome students, introductions, journal club expectations and best practices

August 28, Danielle, Betatrophin: A Hormone that Controls Pancreatic ß Cell Proliferation  http://www.sciencedirect.com/science/article/pii/S0092867413004492#

August 21, Branden, In vitro expansion of single Lgr5(+) liver stem cells induced by Wnt-driven regeneration, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634804/

August 14, Q, Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-ßhttp://www.nature.com/neuro/journal/v16/n5/full/nn.3356.html

August 7, Dr. Wassana Yantasee, Biomedical Engineering, Nanoparticle platforms for targeted delivery of siRNA and chemotherapies

July 31, Jaime, Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse URL: http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.3439.html

July 24, Zach, Genomic responses in mouse models poorly mimic human inflammatory diseases URL: http://www.pnas.org/content/110/9/3507.full.pdf+html

July 17, Julie, Web-scale pharmacovigilance: Listening to signals from the crowd. http://jamia.bmj.com/content/early/2013/02/05/amiajnl-2012-001482.abstract

July 10, Derek; 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. http://www.ncbi.nlm.nih.gov/m/pubmed/18931659/

June 26, 2013 Allison, Malaria-Infected Erythrocyte-Derived Microvesicles Mediate Cellular Communication within the Parasite Population and with the Host Immune System http://www.sciencedirect.com.liboff.ohsu.edu/science/article/pii/S1931312813001510

June 19, 2013 Andy, Cullin-3 Regulates Vascular Smooth Muscle Function and Arterial Blood Pressure via PPAR and RhoA/Rho-Kinase http://www.cell.com/cell-metabolism/retrieve/pii/S1550413112003622

June 12, 2013 Dominic, Early Cortical Hypoperfusion after Subarachnoid Hemorrhage

June 5, 2013 Yossi, Iron, Methamphetamine and Cigarettes

May 29, 2013 Johanna Colgrove, Documentation Preparation--Mastering Word

May 22, 2013 Jenya, Acid Ceramidase Maintains the Chondrogenic Phenotype of Expanded Primary Chondrocytes and Improves the Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637164/

May 15, 2013 Greg, Novel airway imaging applied to neuroimmune interactions in asthma

May 8, 2013 Garth, New Thoughts on Old Blood Clots

May 1, 2013 Dr. James Tanyi, Radiation Medicine, A pilot study on the use of DCE-MRI in the prediction of head and neck cancer response to chemoradiation

April 24, 2013 Charlie, Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET http://www.nature.com/nm/journal/v18/n6/full/nm.2753.html

April 17, 2013 Devon, Identifying Personal Genomes by Surname Inference http://www.sciencemag.org/content/339/6117/321.full.pdf

April 10, 2013 Zip, Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice URL:  http://www.cell.com/cell-stem-cell/abstract/S1934-5909%2813%2900007-6

April 3, 2013 Dr.s Kristina Young M.D., Ph.D. and Sophia Bornstein M.D., Ph.D. Sophia: Tumor-Initiating Cell Microenvironment in Head and Neck Squamous Cell Carcinoma, Kristina: Targeted Alteration of the Tumor Immune Environment to Increase Chemoradiosensitivity in Rectal Cancer Together: transitioning from MD/PhD to residency and beyond

March 20, 2013 Cheryl MYC Suppresses Cancer Metastasis by Direct Transcriptional Silencing of av and ß3 Integrin Subunits http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366024/

March 13, 2013 Kevin, Diagnostic Inaccuracy of Smartphone Applications for Melanoma Detection http://archderm.jamanetwork.com/article.aspx?articleid=1557488

March 6, 2013 Cymon, Inhibition of hepatitis C virus replication by intracellular delivery of multiple siRNAs by nanosomes http://www.nature.com/mt/journal/v20/n9/full/mt2012107a.html

February 27, 2013 Katie L., Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c http://www.ncbi.nlm.nih.gov/pubmed/22521878

February 20, 2013 Anjali, The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells   http://www.sciencedirect.com/science/article/pii/S107476131100505X

February 6 2013 Dr Bob Hitzemann, Behavioral Neuroscience, Systems Biology, Gene Networks and Behavior

January 30, 2013 Rebecca W. Adult hippocampal neurogenesis buffers stress response and depressive behavior, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162077/

January 23, 2013 Dominic, A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid? http://stm.sciencemag.org/content/4/147/147ra111.full.pdf

January 16, 2013 Noah, CCR5 is a receptor for Staphylococcus aureus leukotoxin ED http://www.nature.com/nature/journal/v493/n7430/full/nature11724.html

January 9, 2013 Dr. Landon King, Pulmonary & Critical Care Medicine, Vice Dean for Research, Johns Hopkins University, Acute Respiratory Distress Syndrome:  Be It Hereby Resolved...

January 2, 2013 Dr. Lina Reiss, Otolaryngology, Pitch plasticity and binaural spectral integration with cochlear implants