VGTI

VGTI

Jay Nelson, Ph.D.

Jay A. Nelson, Ph.D. is the founder and director of the Vaccine and Gene Therapy Institute (VGTI) and a core scientist at the ONPRC at OHSU. He is a senior molecular virologist with over 200 papers and reviews on a variety of topics in virology and immunology. The primary focus of Dr. Nelson's research over the past 37 years has centered on the molecular pathogenesis of cytomegalovirus (CMV) and flaviviruses, CMV as a vaccine vector, and vaccine adjuvant development. More recently he has worked with Doctors Alec Hirsch and Dan Streblow to develop a Zika-rhesus macaque model to study viral pathogenesis and develop new vaccines and antivirals. These studies have been supported over the years by RO1s, several contracts and program projects at the VGTI at OHSU that include program project grants to develop cytomegalovirus (CMV) as a vaccine vector for HIV with Dr. Louis Picker, another to elucidate mechanisms of HCMV latency and reactivation and regulation of hematopoiesis in bone marrow transplant patients, and an NIAID contract to develop small molecule agonists to innate factors as vaccine adjuvants for RNA viruses. Dr. Nelson was also the Director of the Pacific Northwest Regional Center of Excellence (PNWRCE) in biodefense and emerging infectious diseases, a large consortium of investigators with extensive expertise and basic and translational research capacity directed at a broad range of NIAID category A-C priority pathogens. Dr. Nelson has numerous awards and distinctions including faculty awards from the American Cancer Society as well as being a Fellow of the American Academy of Microbiology. He was an editor for the Journal of Virology for 8 years and is currently an Associate editor for PLOS Pathogens.

Dr. Nelson is also the founder and Director of the Vaccine and Gene Therapy Institute (VGTI; described later in this section). The founding goal of the VGTI was to assemble a multidisciplinary team of scientists to respond to increasingly serious viral disease threats including AIDS, chronic viral infection-associated diseases, newly emerging viral diseases, and infectious diseases of the elderly. The development of vaccines and novel immune and gene therapeutic approaches to these diseases are the major priorities of the faculty.

Education

  • California State University, Hayward, CA, B.S., Biological Sciences, 1975.
  • Oregon State University, Corvallis, OR, Ph.D., Microbiology, 1980.
  • Postdoctoral Fellow, Fred Hutchinson Cancer Research Center, Seattle, WA, 1980-1984.

Professional record

  • Teaching Assistant, Department of Microbiology, Oregon State University, Corvallis, OR,
  • Predoctoral Trainee, National Institutes of Health, Department of Microbiology, Oregon State University with Dr. Jo-Ann Leong, 1975-1980
  • Research Associate, Tumor Biology Program at Fred Hutchinson Cancer Research Center with Drs. James K. McDougall and Denise A. Galloway, 1980-1981.
  • Postdoctoral Fellow of the National Institutes of Health awarded from the National Cancer Institute, 1981-1984.
  • Assistant Member, Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA, 1984 -1989.
  • Associate Member, Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA, 1989-1992.
  • Adjunct Associate Professor, Department of Pathology, University of California at San Diego, CA, 1990-1992.
  • Professor, Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR, 1992-present
  • Head of Pathobiology and Immunology Division, Oregon Regional Primate Research Center, Beaverton, OR, 1998 to 2000
  • Director of Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Portland, OR, 1998 to present
  • Director of Vaccine and Gene Therapy Institute, Florida, Port St. Lucie, FL 2008 to Present
  • Director of the Pacific Northwest Regional Center of Excellence in Biodefense and Emerging Infectious Diseases 2009 to Present

Publications

  • Hancock MH, Nelson JA. Modulation of the NFκb SignallingPathway by Human Cytomegalovirus. Virology (Hyderabad). 2017 Aug;1(1). pii:104. Epub 2017 Jul 31. [PMID: 29082387]

  • Hansen SG, Piatak M, Ventura AB, Hughes CM, Gilbride RM,Ford JC, Oswald K, Shoemaker R, Li Y, Lewis MS, Gilliam AN, Xu G, Whizin N,Burwitz BJ, Planer SL, Turner JM, Legasse AW, Axthelm MK, Nelson JA, Früh K,Sacha JB, Estes JD, Keele BF, Edlefsen PT, Lifson JD, Picker LJ. Addendum:Immune clearance of highly pathogenic SIV infection. Nature. 2017 Jul6;547(7661):123-124. doi: 10.1038/nature22984. Epub 2017 Jun 21. [PMID:28636599]

  • Crawford LB, Tempel R, Streblow DN, Kreklywich C, Smith P,Picker LJ, Nelson JA, Caposio P. Human Cytomegalovirus Induces Cellular and HumoralVirus-specific Immune Responses in Humanized BLT Mice. Sci Rep. 2017 Apr20;7(1):937. doi: 10.1038/s41598-017-01051-5. [PMID: 28428537]

  • Hirsch AJ, Smith JL, Haese NN, Broeckel RM, Parkins CJ,Kreklywich C, DeFilippis VR, Denton M, Smith PP, Messer WB, Colgin LM, DucoreRM, Grigsby PL, Hennebold JD, Swanson T, Legasse AW, Axthelm MK, MacAllister R,Wiley CA, Nelson JA, Streblow DN. Zika Virus infection of rhesus macaques leadsto viral persistence in multiple tissues. PLoS Pathog. 2017 Mar9;13(3):e1006219. doi: 10.1371/journal.ppat.1006219. [PMID: 28278237]

  • Hancock MH, Hook LM, Mitchell J, Nelson JA;HumanCytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block ProinflammatoryCytokine Production in Response to NF-κB-Activating Factors through DirectDownregulation of IKKα and IKKβ. MBio. 2017 Mar 7;8(2). pii: e00109-17. doi:10.1128/mBio.00109-17.[PMID: 28270578]

  • Burwitz BJ, Malouli D, Bimber BN, Reed JS, Ventura AB,Hancock MH, Uebelhoer LS, Bhusari A, Hammond KB, Espinosa Trethewy RG, Klug A,Legasse AW, Axthelm MK, Nelson JA, Park BS, Streblow DN, Hansen SG, Picker LJ,Früh K, Sacha JB. Cross-Species Rhesus Cytomegalovirus Infection of CynomolgusMacaques. PLoS Pathog. 2016 Nov 9;12(11):e1006014. doi:10.1371/journal.ppat.1006014.[PMID: 27829026]

  • Caviness K, Bughio F, Crawford LB, Streblow DN, Nelson JA,Caposio P, Goodrum F. Complex Interplay of the UL136 Isoforms BalancesCytomegalovirus Replication and Latency. MBio. 2016 Mar 1;7(2):e01986. doi:10.1128/mBio.01986-15.[PMID: 26933055]

  • Hansen SG, Wu HL, Burwitz BJ, Hughes CM, Hammond KB, VenturaAB, Reed JS, Gilbride RM, Ainslie E, Morrow DW, Ford JC, Selseth AN, Pathak R,Malouli D, Legasse AW, Axthelm MK, Nelson JA, Gillespie GM, Walters LC,Brackenridge S, Sharpe HR, López CA, Früh K, Korber BT, McMichael AJ,Gnanakaran S, Sacha JB, Picker LJ. Broadly targeted CD8⁺ T cell responsesrestricted by major histocompatibility complex E. Science. 2016 Feb12;351(6274):714-20. doi: 10.1126/science.aac9475.[PMID: 26797147]

  • MacManiman, J.D., A. Meuser, S. Botto, P. Smith, F. Liu, M. A. Jarvis, J. A. Nelson, and P. Caposio. Human Cytomegalovirus-Encoded pUL7 is a novel CEACAM1-like molecule responsible for promotion of angiogenesis. MBio. 2014 Oct 28;5(6):e02035. (doi: 10.1128/mBio.02035-14.) [PMID: 25352622, PMCID: PMC4217178] 
  • Hook L, Hancock M, Landais I, Grabski R, Britt W, Nelson JA. Cytomegalovirus microRNAs. Curr Opin Virol. 2014 Aug;7:40-6. (DOI: 10.1016/j.coviro.2014.03.015) [PMID: 24769092, PMCID: PMC4149926] Epub 2014 Apr 23.
  • Hook LM, Landais I, Hancock MH, Nelson JA. Techniques for characterizing cytomegalovirus-encoded miRNAs. Methods Mol Biol. 2014;1119:239-65. (DOI: 10.1007/978-1-62703-788-4_14) [PMID: 24639227]
  • Hook, L. M., F. Grey, R. Grabski, R. Tirabassi, T. Doyle, M. Hancock, I Landais, S. Jeng, S. McWeeney, W. Britt, and J. A. Nelson.Cytomegalovirus miRNAs target secretory pathway genes to facilitate formation of the virion assembly compartment and reduce cytokine secretion. Cell Host & Microbe 15:363-73. 2014 Mar 12;15(3):363-73 (DOI: 10.1016/j.chom.2014.02.004) [PMID: 24629342, PMCID: PMC4029511] Journal Impact Factor 12.194.
  • Smith JL, Stein DA, Shum D, Fischer MA, Radu C, Bhinder B, Djaballah H,Nelson JA, Früh K, Hirsch AJ. Inhibition of dengue virus replication by a class of small-molecule compounds that antagonize dopamine receptor d4 and downstream mitogen-activated protein kinase signaling. J Virol. 2014 May;88(10):5533-42. (DOI: 10.1128/JVI.00365-14) [PMID: 24599995, PMCID: PMC4019099] Epub 2014 Mar 5.
  • Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R,Nelson JA, Ross CA, Xing Y, Davidson BL. Transcriptome-wide discovery of microRNA binding sites in human brain. Neuron. 2014 Jan 22;81(2):294-305 (DOI: 10.1016/j.neuron.2013.10.062) [PMID: 24389009, PMCID: PMC4108341] Epub 2014 Jan 2.
  • Hakki M, Goldman DC, Streblow DN, Hamlin KL, Krekylwich CN, Fleming WH,Nelson JA. HCMV infection of humanized mice after transplantation of G-CSF-mobilized peripheral blood stem cells from HCMV-seropositive donors. Biol Blood Marrow Transplant. 2014 Jan;20(1):132-5. (DOI: 10.1016/j.bbmt.2013.10.019) [PMID: 24161922, PMCID: PMC3922710] Epub 2013 Oct 23.
  • Hansen SG, Piatak, Jr. M, Ventura AB, Hughes CM, Gilbride RM, Ford JC, Oswald K, Shoemaker R, Li Y, Lewis MS, Gilliam AN, Xu G, Whizin N, Planner SL, Turner JM, Legasse AW, Axthelm MK, Fukazawa Y, Park H, Edlefsen PT, Nelson JA, Früh K, Sacha JB, Estes JD, Lifson JD, and Picker LJ. Immune clearance of highly pathogenic SIV infection. Nature 502:100-104, 2013 (doi:10.1038/nature12519). [PMID: 24025770; PMCID: PMC3849456]. Journal Impact Factor 42.351
  • Fischer MA, Smith JL, Shum D, Stein DA, Parkins C, Bhinder B, Radu C, Hirsch AJ, Djaballah H, Nelson JA, Früh K. Flaviviruses are sensitive to inhibition of thymidine synthesis pathways. J Virol. 2013 Sep;87(17):9411-9. (doi: 10.1128/JVI.00101-13) [PMID: 23824813, PMCID: PMC3754125 ] Epub 2013 Jul 3.
  • Landais I, Nelson JA. Functional genomics approaches to understand cytomegalovirus replication, latency and pathogenesis. Curr Opin Virol. 2013 Aug;3(4):408-15. (doi: 10.1016/j.coviro.2013.06.002) [PMID: 23816389, PMCID:PMC3748260] Epub 2013 Jun 29.
  • Hansen SG, Sacha JB, Hughes CM, Ford JC, Burwitz BJ, Scholz I, Gilbride RM, Lewis MS, Gilliam AN, Ventura AB, Malouli D, Xu G, Richards R, Whizin N, Reed JS, Hammond KB, Fischer M, Turner JM, Legasse AW, Axthelm MK, Edlefsen PT, Nelson JA, Lifson JD, Früh K, Picker LJ. Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms. Science. 2013 May 24;340(6135):1237874. (doi: 10.1126/science.1237874.) [PMID: 23704576, PMCID: PMC3816976]
  • Hancock MH, Tirabassi RS, Nelson JA. Rhesus cytomegalovirus encodes seventeen microRNAs that are differentially expressed in vitro and in vivo. Virology. 2012 Apr 10;425(2):133-42. (doi: 10.1016/j.virol.2012.01.009.) [PMID: 22305624, PMCID: PMC3592565] Epub 2012 Feb 2.
  • Umashankar M, Petrucelli A, Cicchini L, Caposio P, Kreklywich CN, Rak M, Bughio F, Goldman DC, Hamlin KL, Nelson JA, Fleming WH, Streblow DN, Goodrum F. A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection. PLoS Pathog. 2011 Dec;7(12):e1002444. (doi: 10.1371/journal.ppat.1002444.) [PMID: 22241980, PMCID: PMC3248471] Epub 2011 Dec 29.
  • Viswanathan K, Smith MS, Malouli D, Mansouri M, Nelson JA, Früh K. BST2/Tetherin enhances entry of human cytomegalovirus. PLoS Pathog. 2011 Nov;7(11):e1002332. (doi: 10.1371/journal.ppat.1002332.) [PMID: 22072961, PMCID: PMC3207899] Epub 2011 Nov 3.
  • Tirabassi R, Hook L, Landais I, Grey F, Meyers H, Hewitt H, Nelson J. Human cytomegalovirus US7 is regulated synergistically by two virally encoded microRNAs and by two distinct mechanisms. J Virol. 2011 Nov;85(22):11938-44. (doi: 10.1128/JVI.05443-11) [PMID: 21900172, PMCID: PMC3209316] Epub 2011 Sep 7.
  • Stein DA, Perry ST, Buck MD, Oehmen CS, Fischer MA, Poore E, Smith JL, Lancaster AM, Hirsch AJ, Slifka MK, Nelson JA, Shresta S, Früh K. Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence. J Virol. 2011 Oct;85(19):10154-66. (doi: 10.1128/JVI.05298-11) [PMID: 21795337, PMCID: PMC3196423] Epub 2011 Jul 27
  • Hansen SG, Ford JC, Lewis MS, Ventura AB, Hughes CM, Coyne-Johnson L, Whizin N, Oswald K, Shoemaker R, Swanson T, Legasse AW, Chiuchiolo MJ, Parks CL, Axthelm MK, Nelson JA, Jarvis MA, Piatak M Jr, Lifson JD, Picker LJ. Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature. 2011 May 26;473(7348):523-7. (doi: 10.1038/nature10003.) [PMID: 21562493, PMCID: PMC3102768] Epub 2011 May 11
  • Jarvis MA, Nelson JA. Molecular basis of persistence and latency. In: Arvin A, Campadelli-Fiume G, Mocarski E, Moore PS, Roizman B, Whitley R, Yamanishi K, editors. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Chapter 42. [PMID: 21348100]
  • Shum D, Smith JL, Hirsch AJ, Bhinder B, Radu C, Stein DA, Nelson JA, Früh K, Djaballah H. High-content assay to identify inhibitors of dengue virus infection. Assay Drug Dev Technol. 2010 Oct;8(5):553-70. (doi: 10.1089/adt.2010.0321) [PMID: 20973722, PMCID: PMC2962577]
  • Smith MS, Goldman DC, Bailey AS, Pfaffle DL, Kreklywich CN, Spencer DB, Othieno FA, Streblow DN, Garcia JV, Fleming WH, Nelson JA. Granulocyte-colony stimulating factor reactivates human cytomegalovirus in a latently infected humanized mouse model. Cell Host Microbe. 2010 Sep 16;8(3):284-91 (doi: 10.1016/j.chom.2010.08.001) [PMID: 20833379, PMCID: PMC2945885]
  • Grey F, Tirabassi R, Meyers H, Wu G, McWeeney S, Hook L, Nelson JA. A viral microRNA down-regulates multiple cell cycle genes through mRNA 5'UTRs. PLoS Pathog. 2010 Jun 24;6(6):e1000967. (doi: 10.1371/journal.ppat.1000967) [PMID: 20585629, PMCID: PMC2891821]
  • Hansen SG, Powers CJ, Richards R, Ventura AB, Ford JC, Siess D, Axthelm MK, Nelson JA, Jarvis MA, Picker LJ, Früh K. Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus. Science. 2010 Apr 2;328(5974):102-6. (doi: 10.1126/science.1185350) [PMID: 20360110, PMCID: PMC2883175]
  • Wille PT, Knoche AJ, Nelson JA, Jarvis MA, Johnson DC. A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells. J Virol. 2010 Mar;84(5):2585-96 (doi: 10.1128/JVI.02249-09.) [PMID: 20032184, PMCID: PMC2820920] Epub 2009 Dec 23.
  • Medigeshi GR, Hirsch AJ, Brien JD, Uhrlaub JL, Mason PW, Wiley C, Nikolich-Zugich J, Nelson JA. West nile virus capsid degradation of claudin proteins disrupts epithelial barrier function. J Virol. 2009 Jun;83(12):6125-34. (doi: 10.1128/JVI.02617-08) [PMID: 19369347, PMCID: PMC2687390] Epub 2009 Apr 15.
  • Baca Jones CC, Kreklywich CN, Messaoudi I, Vomaske J, McCartney E, Orloff SL, Nelson JA, Streblow DN. Rat cytomegalovirus infection depletes MHC II in bone marrow derived dendritic cells. Virology. 2009 May 25;388(1) :78-90 (doi:10.1016/j.virol.2009.02.050) [PMID: 19349057, PMCID: PMC2749604] Epub 2009 Apr 5.
  • Vomaske J, Melnychuk RM, Smith PP, Powell J, Hall L, DeFilippis V, Früh K, Smit M, Schlaepfer DD, Nelson JA, Streblow DN. Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility. PLoS Pathog. 2009 Feb;5(2):e1000304 (doi: 10.1371/journal.ppat.1000304) [PMID: 19229316, PMCID: PMC2637432] Epub 2009 Feb 20.
  • Hansen SG, Vieville C, Whizin N, Coyne-Johnson L, Siess DC, Drummond DD, Legasse AW, Axthelm MK, Oswald K, Trubey CM, Piatak M Jr, Lifson JD, Nelson JA, Jarvis MA, Picker LJ. Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nat Med. 2009 Mar;15(3):293-9 (doi: 10.1038/nm.1935) [PMID: 19219024, PMCID: PMC2720091] Epub 2009
  • Dumortier J, Streblow DN, Moses AV, Jacobs JM, Kreklywich CN, Camp D, Smith RD, Orloff SL, Nelson JA. Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing. J Virol. 2008 Jul;82(13):6524-35 (doi: 10.1128/JVI.00502-08) [PMID: 18448536, PMCID: PMC2447085] Epub 2008 Apr 30
  • Medigeshi GR, Hirsch AJ, Streblow DN, Nikolich-Zugich J, Nelson JA. West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of alphavbeta3 integrin. J Virol. 2008 Jun;82(11):5212-9 (doi: 10.1128/JVI.00008-08) [PMID: 18385233, PMCID: PMC2395215] Epub 2008 Apr 2
  • Grey F, Nelson J. Identification and function of human cytomegalovirus microRNAs. J Clin Virol. 2008 Mar;41(3):186-91 (doi: 10.1016/j.jcv.2007.11.024) [PMID: 18243786, PMCID: PMC2706132]
  • Grey F, Meyers H, White EA, Spector DH, Nelson J. A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication. PLoS Pathog. 2007 Nov;3(11):e163 [PMID: 17983268, PMCID: PMC2048532]
  • Ryckman BJ, Rainish BL, Chase MC, Borton JA, Nelson JA, Jarvis MA, Johnson DC. Characterization of the human cytomegalovirus gH/gL/UL128-131 complex that mediates entry into epithelial and endothelial cells. J Virol. 2008 Jan;82(1):60-70 [PMID: 17942555, PMCID: PMC2224386] Epub 2007 Oct 17
  • Streblow DN, Orloff SL, Nelson JA. Acceleration of allograft failure by cytomegalovirus. Curr Opin Immunol. 2007 Oct;19(5):577-82 [PMID: 17716883, PMCID: PMC3509935] Epub 2007 Aug 22.
  • Medigeshi GR, Lancaster AM, Hirsch AJ, Briese T, Lipkin WI, Defilippis V, Früh K, Mason PW, Nikolich-Zugich J, Nelson JA. West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis. J Virol. 2007 Oct;81(20):10849-60 [PMID: 17686866, PMCID: PMC2045561] Epub 2007 Aug 8
  • Streblow DN, van Cleef KW, Kreklywich CN, Meyer C, Smith P, Defilippis V, Grey F, Früh K, Searles R, Bruggeman C, Vink C, Nelson JA, Orloff SL. Rat cytomegalovirus gene expression in cardiac allograft recipients is tissue specific and does not parallel the profiles detected in vitro. J Virol. 2007 Apr;81(8):3816-26 [PMID: 17251289, PMCID: PMC1866122] Epub 2007 Jan 24.
  • Jarvis MA, Nelson JA. Human cytomegalovirus tropism for endothelial cells: not all endothelial cells are created equal. J Virol. 2007 Mar;81(5):2095-101 [PMID: 16956936, PMCID: PMC1865914] Epub 2006 Sep 6
  • Jarvis MA, Borton JA, Keech AM, Wong J, Britt WJ, Magun BE, Nelson JA. Human cytomegalovirus attenuates interleukin-1beta and tumor necrosis factor alpha proinflammatory signaling by inhibition of NF-kappaB activation. J Virol. 2006 Jun;80(11):5588-98 [PMID: 16699040, PMCID: PMC1472148]
  • DeFilippis VR, Robinson B, Keck TM, Hansen SG, Nelson JA, Früh KJ. Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection. J Virol. 2006 Jan;80(2):1032-7 [PMID: 16379004, PMCID: PMC1346858]
  • Ryckman BJ, Jarvis MA, Drummond DD, Nelson JA, Johnson DC. Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion. J Virol. 2006 Jan;80(2):710-22 [PMID: 16378974, PMCID: PMC1346879]
  • Hegde NR, Dunn C, Lewinsohn DM, Jarvis MA, Nelson JA, Johnson DC. Endogenous human cytomegalovirus gB is presented efficiently by MHC class II molecules to CD4+ CTL. J Exp Med. 2005 Oct 17;202(8):1109-19 [PMID: 16216889, PMCID: PMC2213219] Epub 2005 Oct 10.
  • Sylwester AW, Mitchell BL, Edgar JB, Taormina C, Pelte C, Ruchti F, Sleath PR, Grabstein KH, Hosken NA, Kern F, Nelson JA, Picker LJ. Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med. 2005 Sep 5;202(5):673-85. [PMID: 16147978, PMCID: PMC2212883]
  • Grey F, Antoniewicz A, Allen E, Saugstad J, McShea A, Carrington JC, Nelson J. Identification and characterization of human cytomegalovirus-encoded microRNAs. J Virol. 2005 Sep;79(18):12095-9. [PMID: 16140786, PMCID: PMC1212634]
  • Hirsch AJ, Medigeshi GR, Meyers HL, DeFilippis V, Früh K, Briese T, Lipkin WI, Nelson JA. The Src family kinase c-Yes is required for maturation of West Nile virus particles. J Virol. 2005 Sep;79(18):11943-51. [PMID: 16140770, PMCID: PMC1212629]
  • Melnychuk RM, Smith P, Kreklywich CN, Ruchti F, Vomaske J, Hall L, Loh L, Nelson JA, Orloff SL, Streblow DN. Mouse cytomegalovirus M33 is necessary and sufficient in virus-induced vascular smooth muscle cell migration. J Virol. 2005 Aug;79(16):10788-95. [PMID: 16051870, PMCID: PMC1182681]
  • Streblow DN, Kreklywich CN, Smith P, Soule JL, Meyer C, Yin M, Beisser P, Vink C, Nelson JA, Orloff SL. Rat cytomegalovirus-accelerated transplant vascular sclerosis is reduced with mutation of the chemokine-receptor R33. Am J Transplant. 2005 Mar;5(3):436-42. [PMID: 15707397]
  • Rue CA, Jarvis MA, Knoche AJ, Meyers HL, DeFilippis VR, Hansen SG, Wagner M, Früh K, Anders DG, Wong SW, Barry PA, Nelson JA. A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism. J Virol. 2004 Nov;78(22):12529-36. [PMID: 15507640, PMCID: PMC525102]
  • Varnum SM, Streblow DN, Monroe ME, Smith P, Auberry KJ, Pasa-Tolic L, Wang D, Camp DG 2nd, Rodland K, Wiley S, Britt W, Shenk T, Smith RD, Nelson JA. Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome. J Virol. 2004 Oct;78(20):10960-6. Erratum in: J Virol. 2004 Dec;78(23):13395. [PMID: 15452216, PMCID: PMC521840]
  • Melnychuk RM, Streblow DN, Smith PP, Hirsch AJ, Pancheva D, Nelson JA. Human cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Galpha12. J Virol. 2004 Aug;78(15):8382-91. [PMID: 15254210, PMCID: PMC446127]
  • Henderson WW, Ruhl R, Lewis P, Bentley M, Nelson JA, Moses AV. Human immunodeficiency virus (HIV) type 1 Vpu induces the expression of CD40 in endothelial cells and regulates HIV-induced adhesion of B-lymphoma cells. J Virol. 2004 May;78(9):4408-20. [PMID: 15078922, PMCID: PMC387678]
  • Jarvis MA, Jones TR, Drummond DD, Smith PP, Britt WJ, Nelson JA, Baldick CJ. Phosphorylation of human cytomegalovirus glycoprotein B (gB) at the acidic cluster casein kinase 2 site (Ser900) is required for localization of gB to the trans-Golgi network and efficient virus replication. J Virol. 2004 Jan;78(1):285-93. [PMID: 14671110, PMCID: PMC303410]
  • Streblow DN, Vomaske J, Smith P, Melnychuk R, Hall L, Pancheva D, Smit M, Casarosa P, Schlaepfer DD, Nelson JA. Human cytomegalovirus chemokine receptor US28-induced smooth muscle cell migration is mediated by focal adhesion kinase and Src. J Biol Chem. 2003 Dec 12;278(50):50456-65. [PMID: 14506272] Epub 2003 Sep 22.
  • Hammarlund E, Lewis MW, Hansen SG, Strelow LI, Nelson JA, Sexton GJ, Hanifin JM, Slifka MK. Duration of antiviral immunity after smallpox vaccination. Nat Med. 2003 Sep;9(9):1131-7. [PMID: 12925846] Epub 2003 Aug 17.
  • Streblow DN, Nelson JA. Models of HCMV latency and reactivation. Trends Microbiol. 2003 Jul;11(7):293-5. [PMID: 12875809]
  • Moses AV, Jarvis MA, Raggo C, Bell YC, Ruhl R, Luukkonen BG, Griffith DJ, Wait CL, Druker BJ, Heinrich MC, Nelson JA, Fruh K. A functional genomics approach to Kaposi's sarcoma. Ann N Y Acad Sci. 2002 Dec;975:180-91. [PMID: 12538164]
  • Streblow DN, Kreklywich C, Yin Q, De La Melena VT, Corless CL, Smith PA, Brakebill C, Cook JW, Vink C, Bruggeman CA, Nelson JA, Orloff SL. Cytomegalovirus-mediated upregulation of chemokine expression correlates with the acceleration of chronic rejection in rat heart transplants. J Virol. 2003 Feb;77(3):2182-94. [PMID: 12525653, PMCID: PMC140920]
  • Strelow L, Janigro D, Nelson JA. Persistent SIV infection of a blood-brain barrier model. J Neurovirol. 2002 Aug;8(4):270-80. [PMID: 12161812]
  • Jarvis MA, Nelson JA. Human cytomegalovirus persistence and latency in endothelial cells and macrophages. Curr Opin Microbiol. 2002 Aug;5(4):403-7. [PMID: 12160860]
  • Moses AV, Jarvis MA, Raggo C, Bell YC, Ruhl R, Luukkonen BG, Griffith DJ, Wait CL, Druker BJ, Heinrich MC, Nelson JA, Früh K. Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells. J Virol. 2002 Aug;76(16):8383-99. [PMID: 12134042, PMCID: PMC155158]
  • Jarvis MA, Nelson JA. Mechanisms of human cytomegalovirus persistence and latency. Front Biosci. 2002 Jun 1;7:d1575-82. [PMID: 12045013]
  • Jarvis MA, Fish KN, Söderberg-Naucler C, Streblow DN, Meyers HL, Thomas G, Nelson JA. Retrieval of human cytomegalovirus glycoprotein B from cell surface is not required for virus envelopment in astrocytoma cells. J Virol. 2002 May;76(10):5147-55. [PMID: 11967330, PMCID: PMC136176]