Grants and Awards

Jay Nelson, Director

Antiviral drug discovery and development center: Project 3: Flaviviruses
Development of immunlgenicity- and efficacy-optimized CMV vectors for an HIV/AIDS vaccine
HCMV miRNA regulation of secretion and formation of the viral assembly compartment

Human cytomegalovirus dysregulation of host hematopoietic progenitor cell signaling pathways to modulate latency, reactivation, and hematopoiesis during transplantation
Molecular aspects of cytomegalovirus latency
Targeting IRFs for Immune adjuvant Enhancement of Vaccine immunogenicity
International Herpesvirus Workshop
Development of Novel STING Pathway Agonist as Vaccine Adjuvants

Louis Picker, Associate Director

Consortia for Innovative AIDS Research in Nonhuman Primates (Focus 1)
Consortia for Innovative AIDS Research in Nonhuman Primates (Focus 2)
Consortium for Innovative AIDS Research in Nonhuman Primates: Administrative Core
DARE: Delaney AIDS Research Enterprise to Find a Cure. Initial Research Focus 1: Targeting B Cell Follicles as a Strategy for HIV Remission/Eradication
DARE: Delaney AIDS Research Enterprise to Find a Cure: Management and Operations
Development of Attenuated CMV Vectors for an HIV/AIDS Vaccine
Development of Immunogenicity- and Efficacy-Optimized CMV Vectors for an HIV/AIDS Vaccine
Development of Optimized CMV/TB Vectors: OHSU/AERAS Project 3 Proposal
Induction of Broad Functional Class II Restricted CD8+ T Cell Responses: Translation from NHP to Humans
Program Development for VGTI
Understanding CMV-TB Induced Protection Against TB Disease
Viral Reservoir Biomarkers in SIV-Infected Macaques
Cascade IMPAc-TB
CMV Vector Program -Pre-clinical Studies to Support Product Development
CMV-TB Study #5
 

Klaus Fruh, Professor

A Cytomegalovirus-based Vaccine Targeting the Pre-erythrocytic Stage of Malaria
Development of Immunogenicity- and Efficacy-Optimized CMV Vectors for an HIV/AIDS Vaccine
Evasion of Antigen Presentation by Rhesus Cytomegalovirus
Identification of MHC-E Restricted Peptides in Human Tumor-associated antigens (TAA)
Immunologic and virologic determinants of congenital cytomegalovirus transmission and disease in rhesus monkeys: Project 2: Viral determinants of fetal  RhCMV transmission
Immunologic and virologic determinants of congenital cytomegalovirus transmission and disease in rhesus monkeys: Project 3: Viral determinants of fetal RhCMV transmission
Prostate cancer antigen presentation by HLA-E as a new target mechanism for immunotherapy

Scott Wong, Professor

Investigating the Development of AIDS and Non-AIDS Defining Cancers in Aged SIV-Infected Rhesus Macaques
Modified Flavonoids as Selective Inhibitors of Hylauronidases for the Promotion of Remyelination
Rhesus HHV-8 homologue in AIDS-related malignancies
A multivalent prophylactic vaccine against EBV primary infection and prevention of EBV-associated malignancies

Jacob Estes, Professor and Chief

Attenuating inflammation to restore GI tract integrity and reduce viral reservoirs during cART
Harnessing IL-10 in cART treated SIV infected macaques to restore immunity and to eradicate HIV
Novel ISH Approaches to Quantify Replication Competent Reservoirs
Comprehensive Characterization of Tissue Viral Reservoirs and their Cellular Immune Neighborhoods In Situ to identify Biomarkers of Viral Reactivation
Defining Mechanisms of Viral Persistence in Situ at the Single-Cell Level
Cascade IMPAc-TB
Immune Interventions in SIV-Infected Art Suppressed Infant Macaques
HIV Reservoir Ecology of Viral Remission
Determining the Relative Contribution of CD4 T Cells and Macrophages to HIV Persistence and Rebound
Complement receptor 2 (CR2) antibody to flush the follicular dendritic cell HIV reservoir for HIV Cure
Harnessing IL-10 in cART treated SIV infected macaques to restore immunity and to eradicate HIV
Selection and Evolution of HIV-1 Reservoir Cells in Blood and Tissues

Michael Axthelm, Professor

Development of Immunogenicity- and Efficacy-Optimized CMV Vectors for an HIV/AIDS Vaccine
Mechanistic Analysis of Zika Virus Induced Placental Damage During Pregnancy

Jonah Sacha, Professor

A nonhuman primate model of stem cell transplantation to understand determinants of post-transplant SIV clearance
A universal MHC-E- restricted T cell vaccine for HIV
Probing the dynamics of infant immunity to limit HIV persistence
Reducing Latent Viral Reservoirs in Infant Macaques
Understanding Unconventional CD8+ T cell Responses in Protection from HIV
Effect of obesity on HIV pathogenesis, antiretroviral therapy, and metabolic comorbidities
Reducing Latent Viral Reservoirs in Infant Macaques
A CCR5 Blocking Antibody as HIV Pre-exposure Prophylaxis
GPP Grand Challenges: An Unconventionally MHC-restricted T Cell Vaccine for Influenza
Defining the Impact of Immunodeficiency Virus Infection on Mycobacteria-Specific, Unconventional CD8+ T cells
A Solid-Phase, Long-Acting CCR5 Monoclonal Antibody for HIV Transmission
An IL-15 Superagonist Approach to Clear the Latent Viral Reservoir

Ashlee Moses, Professor

Heme oxygenase-1 as a tumor factor and therapeutic target for Kaposi sarcoma
KSHV Manipulates Host Iron Metabolism and Ferroptotic Cell Death Pathways, Creating Novel Vulnerability Points for Therapeutic Intervention

Daniel Streblow, Professor

Antiviral Drug Discovery and Development Center: Project 2: Novel Therapeutics for Emerging Alphavirus
Biologically Targeted Vaccine for Chikungunya
Characterizing the Role of CMV Latency in Solid Organ Transplant Rejection
Development of Immunogenicity- and Efficacy-Optimized CMV Vectors for an HIV/AIDS Vaccine
Human Cytomegalovirus dysregulation of host hematopoietic progenitor cell signaling pathways to modulate latency, reactivation, and hematopoiesis during transplantation
Mechanistic Analysis of Zika Virus Induced Placental Damage During Pregnancy
Program Development for VGTI
External Site Evaluation of RT-QPCR assay for SARS-Co V2 infection

Patrizia Caposio, Associate Professor

Human Cytomegalovirus dysregulation of host hematopoietic progenitor cell signaling pathways to modulate latency, reactivation, and hematopoiesis during transplantation

Scott Hansen, Associate Professor

Efficacy of strain 68-1 RhCMV vectors expressing 5' leader polypeptieds
A Cytomegalovirus-based therapeutic vaccine for chronic hepatitis B
CD15 Long Hauler - VGTI Study H

Afamefuna Okoye, Associate Professor

To Determine the Effect of Toll-like Receptor (TLR) Agonists on SIV Production in Effectively Treated SIV-infected Macaques
Development of an mRNA-Based Therapeutic HIV/AIDS Vaccine
Targeting the HIV/SIV reservoir at time of ART initiation

 

Victor DeFilippis, Associate Professor

Mechanistic Exploration of cGAS-STING-Mediated Vaccine Enhancement
Targeting IRFs for Immune Adjuvant Enhancement of Vaccine Immunogenicity

Lydie Trautmann, Associate Professor

HIV Vaccine Research and Development
Towards HIV Eradication using a Novel TAT Inhibitor
Critical Role of Cytotoxic T Cells in HIV Neuropathogenesis
The Latent HIV Reservoir in Early Treated Thai Children
Targeting the HIV/SIV reservoir at time of ART initiation
Targeting STAT SUMOylation for HIV Cure Strategies

Alec Hirsch, Assistant Professor

Program Development for VGTI
Targeting IRFs for Immune Adjuvant Enhancement of Vaccine Immunogenicity
Neuronal activity modulation and age-related neurodegeneration
Development of a Virus-Like Particle Vaccine for Powassan Virus
Safety evaluation of an attenuated, oncolytic Zika virus

Benjamin Burwitz, Assistant Professor

Adoptive MHC-E-Restricted T Cell Therapy for the Treatment of Chronic Hepatitis B Virus Infection
Creation of a chronic HBV infection model in rhesus macaques
Mediators of Fatty Liver Disease During HIV/SIV and cART Treatment
Program Development for VGTI
Rhesus Macaque Somatic Cell Gene Editing Resource
Bispecific Antibodies Directed to CD3 and HBsAg to Treat Chronic Hepatitis B Virus
Learning from the Ebola success: Can a mAb also save lives after yellow fever infection?
A Rhesus Macaque Model of HIV and HBV co-infection

Daniel Malouli, Research Assistant Professor

Development of Immunogenicity- and Efficacy-Optimized CMV Vectors for an HIV/AIDS Vaccine

Brandon Wilder, Assistant Professor

IPA - Brandon Wilder
Discovery of novel antimalarial drugs
FRGhuHep Malaria Challenge Model
IPA - Brandon Wilder 2 Year Continuation

Rebecca Skalsky, Assistant Professor

microRNA Regulation of Gamma-herpesvirus Latency and Reactivation
Validation of Conserved Epstein-Barr Virus microRNA Targets Involved in B Cell Differentiation
Regulation of host miRNA activity by Epstein-Barr virus BHRF1

Helen Wu, Assistant Staff Scientist

Establishing a non-human primate model of HLA-E-restricted CD8+ T cells