Grants and Awards

Jay Nelson, Director

Antiviral drug discovery and development center: Project 3: Flaviviruses
Development of immunlgenicity- and efficacy-optimized CMV vectors for an HIV/AIDS vaccine
HCMV miRNA regulation of secretion and formation of the viral assembly compartment

Human cytomegalovirus dysregulation of host hematopoietic progenitor cell signaling pathways to modulate latency, reactivation, and hematopoiesis during transplantation
Molecular aspects of cytomegalovirus latency
Targeting IRFs for Immune adjuvant Enhancement of Vaccine immunogenicity

Louis Picker, Associate Director

Consortia for Innovative AIDS Research in Nonhuman Primates (Focus 1)
Consortia for Innovative AIDS Research in Nonhuman Primates (Focus 2)
Consortium for Innovative AIDS Research in Nonhuman Primates: Administrative Core
DARE: Delaney AIDS Research Enterprise to Find a Cure. Initial Research Focus 1: Targeting B Cell Follicles as a Strategy for HIV Remission/Eradication
DARE: Delaney AIDS Research Enterprise to Find a Cure: Management and Operations
Development of Attenuated CMV Vectors for an HIV/AIDS Vaccine
Development of Immunogenicity- and Efficacy-Optimized CMV Vectors for an HIV/AIDS Vaccine
Development of Optimized CMV/TB Vectors: OHSU/AERAS Project 3 Proposal
Induction of Broad Functional Class II Restricted CD8+ T Cell Responses: Translation from NHP to Humans
Program Development for VGTI
Understanding CMV-TB Induced Protection Against TB Disease

Klaus Fruh, Professor

A Cytomegalovirus-based Vaccine Targeting the Pre-erythrocytic Stage of Malaria
Development of Immunogenicity- and Efficacy-Optimized CMV Vectors for an HIV/AIDS Vaccine
Evasion of Antigen Presentation by Rhesus Cytomegalovirus
Identification of MHC-E Restricted Peptides in Human Tumor-associated antigens (TAA)

Scott Wong, Professor

Investigating the Development of AIDS and Non-AIDS Defining Cancers in Aged SIV-Infected Rhesus Macaques
Modified Flavonoids as Selective Inhibitors of Hylauronidases for the Promotion of Remyelination
Rhesus HHV-8 homologue in AIDS-related malignancies

Jacob Estes, Professor and Chief

Attenuating inflammation to restore GI tract integrity and reduce viral reservoirs during cART
Harnessing IL-10 in cART treated SIV infected macaques to restore immunity and to eradicate HIV

Michael Axthelm, Professor

Development of Immunogenicity- and Efficacy-Optimized CMV Vectors for an HIV/AIDS Vaccine
Mechanistic Analysis of Zika Virus Induced Placental Damage During Pregnancy

Ashlee Moses, Associate Professor

Heme oxygenase-1 as a tumor factor and therapeutic target for Kaposi sarcoma

Daniel Streblow, Associate Professor

Antiviral Drug Discovery and Development Center: Project 2: Novel Therapeutics for Emerging Alphavirus
Biologically Targeted Vaccine for Chikungunya
Characterizing the Role of CMV Latency in Solid Organ Transplant Rejection
Development of Immunogenicity- and Efficacy-Optimized CMV Vectors for an HIV/AIDS Vaccine
Human Cytomegalovirus dysregulation of host hematopoietic progenitor cell signaling pathways to modulate latency, reactivation, and hematopoiesis during transplantation
Mechanistic Analysis of Zika Virus Induced Placental Damage During Pregnancy
Program Development for VGTI

Patrizia Caposio, Assistant Professor

Human Cytomegalovirus dysregulation of host hematopoietic progenitor cell signaling pathways to modulate latency, reactivation, and hematopoiesis during transplantation

Scott Hansen, Associate Professor

Efficacy of strain 68-1 RhCMV vectors expressing 5' leader polypeptieds

Jonah Sacha, Associate Professor

A nonhuman primate model of stem cell transplantation to understand determinants of post-transplant SIV clearance
A universal MHC-E- restricted T cell vaccine for HIV
Probing the dynamics of infant immunity to limit HIV persistence
Reducing Latent Viral Reservoirs in Infant Macaques
Understanding Unconventional CD8+ T cell Responses in Protection from HIV

Afamefuna Okoye, Assistant Research Professor

To Determine the Effect of Toll-like Receptor (TLR) Agonists on SIV Production in Effectively Treated SIV-infected Macaques

Rebecca Skalsky, Assistant Professor

microRNA Regulation of Gamma-herpesvirus Latency and Reactivation
Validation of Conserved Epstein-Barr Virus microRNA Targets Involved in B Cell Differentiation

Victor DeFilippis, Assistant Professor

Mechanistic Exploration of cGAS-STING-Mediated Vaccine Enhancement
Targeting IRFs for Immune Adjuvant Enhancement of Vaccine Immunogenicity

Benjamin Burwitz, Assistant Research Professor

Adoptive MHC-E-Restricted T Cell Therapy for the Treatment of Chronic Hepatitis B Virus Infection
Creation of a chronic HBV infection model in rhesus macaques
Mediators of Fatty Liver Disease During HIV/SIV and cART Treatment
Program Development for VGTI
Rhesus Macaque Somatic Cell Gene Editing Resource

Justin Greene, Research Assistant Professor

Antibody-based enhancement of CMV vaccine vectors for HIV

Alec Hirsch, Assistant Professor

Program Development for VGTI
Targeting IRFs for Immune Adjuvant Enhancement of Vaccine Immunogenicity

Daniel Malouli, Research Assistant Professor

Development of Immunogenicity- and Efficacy-Optimized CMV Vectors for an HIV/AIDS Vaccine

Helen Wu, Assistant Staff Scientist

Establishing a non-human primate model of HLA-E-restricted CD8+ T cells