Research Overview and Faculty Interests

Ongoing projects can be divided into the following different areas.

Neurobiology

Dr. Marjorie Grafe is studying CNS pathology in models of brain injury in rodents. Dr. Randy Woltjer is examining the effects of neurodegenerative diseases and myopathies in humans and in rodent models.

Hematologic malignancies

Dr. Guang Fan is investigating the predictive and prognostic impacts of oncogenic mutations in cases of AML and pre-B ALL. Dr. Marc Loriaux has developed a novel screening method for assessing drug sensitivity in newly diagnosed cases of AML. Dr. Jennifer Dunlap is researching the feasibility of flow cytometry analysis to identify differences in lymphoma subtypes.

Dr. Rita Braziel continues to work with Nanostring to validate a gene expression profiling assay for diffuse large B-cell lymphomas, and is in the process of acquiring approval from the FDA for this assay. Dr. Rita Braziel continues to be the OHSU principal investigator for the Lymphoma/Leukemia Molecular Profiling Project (LLMPP), and is also collaborating on a project with the University of Washington to develop a new method of minimal residual disease detection after therapy for follicular lymphomas patients.

Placenta and fetal growth

Dr. Terry Morgan continues his investigations into the effects of altered blood flow on the development and function of the placenta; his newest study utilizes a mouse model to test the effects of receptor antibodies on spiral artery remodeling. Decreased blood flow not only predisposes to pre-eclampsia, but results in reduced fetal size and a life-time increased risk for hypertension after birth.

Molecular diagnostics

Dr. Richard Press is developing novel assays for a number of different infectious disease agents, as well as tests for minimal residual disease testing in hematologic tumors. Dr. Chris Corless is pursuing applications of massively parallel sequencing in translational and clinical studies.

Solid tumors

Dr. Christopher Corless has developed mass spectroscopy-based panels that are used for oncogene mutation screening across a variety of solid tumors and hematologic malignancies. Dr. Terry Morgan is studying novel markers for the diagnosis of HPV-related lesions of the cervix and oropharynx.

Renal pathology

Dr. Nicole Andeen and Dr. Mazdak Khalighi study clinicopathologic correlations of a wide spectrum renal diseases including autoimmune, genetic, metabolic, hematologic, and neoplasia-related kidney diseases. We collaborate with nephrologists, rheumatologists, proteomics faculty, basic scientists, and others in the study of diseases that affect the kidney.

Other research activities

Dr. Ken Gatter is studying legal issues related to property rights to human tissue samples, and the use of human tissue in research. He is also establishing a medical-legal partnership study; this pilot project’s focus is on a select socioeconomic grouping of patients at a local OHSU clinic.