Sunwen Chou, MD

Sunwen Chou, MD

Sunwen Chou, MD
Professor of Medicine
Division of Infectious Diseases, OHSU
Medical Research Service, VAMC


B.A. – Dartmouth College, 1973 
BMS – Dartmouth Medical School, 1975 
M.D. – UCLA School of Medicine, 1977 


Medicine – UCLA Hospital, 1977-1980


ID – Stanford University, 1980-1983

Research interests

Human cytomegalovirus antivirals and drug resistance

Selected publications

  1. Chou S. Cytomegalovirus UL97 mutations in the era of ganciclovir and maribavir. Rev Medical Virol 2008;18:233-46.
  2. Chou S, Marousek GI. Accelerated evolution of maribavir resistance in a cytomegalovirus exonuclease domain II mutant. J Virol 2008;82:246-53.
  3. Strasfeld S, Lee I, Tatarowicz W, Villano S, Chou S. Virologic characterization of multi-drug-resistant cytomegalovirus infection in two transplant recipients treated with maribavir. J Infect Dis 2010;202:104-8.
  4. Chou S, Ercolani RJ, Marousek G, Bowlin T. Cytomegalovirus UL97 kinase catalytic domain mutations that confer multi-drug resistance. Antimicrob Agents Chemother 2013;57: 3375-9.
  5. Chou S, Boivin G, Ives J, Elston R. Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial. J Infect Dis 2014;209:1219-26.
  6. Webel R, Hakki M, Prichard MN, Rawlinson WD, Marschall M, Chou S. Differential properties of cytomegalovirus pUL97 kinase isoforms affect viral replication and maribavir susceptibility. J Virol 2014;88:4776-85.
  7. Chou S, Ercolani RJ, Sahoo MK, Lefterova MI, Strasfeld LM, Pinsky BA. Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing. Antimicrob Agents Chemother 2014;58:4697-4702.
  8. Chou S. Rapid in vitro evolution of human cytomegalovirus UL56 mutations that confer letermovir resistance. Antimicrob Agents Chemother 2015;59:6588-93.
  9. Chou S, Ercolani RJ, Lanier ER. Novel cytomegalovirus UL54 DNA polymerase gene mutations selected in vitro that confer brincidofovir resistance. Antimicrob Agents Chemother 2016;60:3845-8.
  10. Chou S. Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. Antiviral Res 2017;138:57-60.
  11. Chou S, Ercolani RJ, Vanarsdall AL. Differentiated levels of ganciclovir resistance conferred by mutations at codons 591-603 of the cytomegalovirus UL97 kinase gene. J Clin Microbiol 2017;55:2098-2104.