Structural and functional studies of molecular machines in the ubiquitin system, presented by Minglei Zhao, Assistant Professor, Department of Biochemistry and Molecular Biology, University of Chicago
When |
November 8, 2022
12 p.m. to 1 p.m.
![]() Abstract: The ubiquitin system plays important roles in many physiological processes in eukaryotes. In this talk, I will present our recent progress on structural and functional characterizations of two important molecular machines involved in the ubiquitin system, p97 and Ubr1. p97 is a type-II AAA ATPase and acts as a central hub to process various ubiquitinated substrates in the ubiquitin system. Human p97 is associated with several neurodegenerative diseases and is also a cancer drug target. Ubr1 is the first genetically cloned E3 ligase, and is involved in the N-degron pathway. We used single-particle cryo-EM as a major tool to determine their structures in complex with the ubiquitinated substrates in multiple states, which provided mechanistic insights into these molecular machines. Samantha Wagner
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Where |
Campus:
Building:
3232 SW Research Drive
Portland,
Oregon
97239
Room: M1441 Vollum Auditorium
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Contact Information |
Samantha Wagner
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Abstract:
The ubiquitin system plays important roles in many physiological processes in eukaryotes. In this talk, I will present our recent progress on structural and functional characterizations of two important molecular machines involved in the ubiquitin system, p97 and Ubr1. p97 is a type-II AAA ATPase and acts as a central hub to process various ubiquitinated substrates in the ubiquitin system. Human p97 is associated with several neurodegenerative diseases and is also a cancer drug target. Ubr1 is the first genetically cloned E3 ligase, and is involved in the N-degron pathway. We used single-particle cryo-EM as a major tool to determine their structures in complex with the ubiquitinated substrates in multiple states, which provided mechanistic insights into these molecular machines.