Recent Publications

Jorgensen ET, Gonzalez AE, Harkness JH, Hegarty DM, Thakar A, Burchi DJ, Aadland JA, Aicher SA, Sorg BA, Brown TE. Cocaine memory reactivation induces functional adaptations within parvalbumin interneurons in the rat medial prefrontal cortex [published online ahead of print, 2020 Aug 4]. Addict Biol. 2020;e12947.

Shi Z, Wong J, Brooks VL. Obesity: sex and sympatheticsBiol Sex Differ. 2020;11(1):10. Published 2020 Mar 11.

Shi Z, Pelletier NE, Wong J, Li B, Sdrulla AD, Madden CJ, Marks DL, Brooks VL. Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus. Elife. 2020 Jun 15;9:e55357.

Guyenet PG, Stornetta RL, Souza GMPR, Abbott SBG, Brooks VL. Neuronal Networks in Hypertension: Recent AdvancesHypertension. 2020;76(2):300-311.

Brooks VL, Fu Q, Shi Z, Heesch CM. Adaptations in autonomic nervous system regulation in normal and hypertensive pregnancyHandb Clin Neurol. 2020;171:57-84.

Shi Z, Zhao D, Cassaglia PA, Brooks VL. Sites and sources of sympathoexcitation in obese male rats: role of brain insulin. Am J Physiol Regul Integr Comp Physiol. 2020 Jan 22.

Hong X, Daiker J, Sadilek M, DeBarber AE, Chiang J, Duan J, Bootsma AH, Huidekoper HH, Vaz FM, Gelb MH. Toward newborn screening of cerebrotendinous xanthomatosis: results of a biomarker research study using 32,000 newborn dried blood spots [published online ahead of print, 2020 Jun 10]. Genet Med.

Varin J, Reynolds MM, Bouzidi N, Tick S, Wohlschlegel J, Becquart O, Michiels C, Dereure O, Duvoisin RM, Morgans CW, Sahel JA, Samaran Q, Guillot B, Pulido JS, Audo I, Zeitz C. Identification and characterization of novel TRPM1 autoantibodies from serum of patients with melanoma-associated retinopathy [published correction appears in PLoS One. 2020 May 13;15(5):e0233424]. PLoS One. 2020;15(4):e0231750. Published 2020 Apr 23.

Wang L, Olivas A, Francis Stuart SD, Tapa S, Blake MR, Woodward WR, Habecker BA, Ripplinger CM. Cardiac sympathetic nerve transdifferentiation reduces action potential heterogeneity after myocardial infarction. Am J Physiol Heart Circ Physiol. 2020 Mar 1;318(3):H558-H565.

Amodei R, Gribbin K, He W, Lindgren I, Corder KR, Jonker SS, Estill CT, Coolen LM, Lehman MN, Whitler W, Stormshak F, Roselli CE. Role for Kisspeptin and Neurokinin B in Regulation of Luteinizing Hormone and Testosterone Secretion in the Fetal Sheep. Endocrinology. 2020 Feb 1.

Hartley MD, Shokat MD, DeBell MJ, Banerji T, Kirkemo LL, Scanlan TS. Pharmacological Complementation Remedies an Inborn Error of Lipid MetabolismCell Chem Biol. 2020;27(5):551-559.e4.

Huey J, Keutler K, Schultz C. Chemical Biology Toolbox for Studying Pancreatic Islet Function - A Perspective. Cell Chem Biol. 2020;27(8):1015-1031

Müller R, Citir M, Hauke S, Schultz C. Synthesis and Cellular Labeling of Caged Phosphatidylinositol Derivatives. Chemistry. 2020 Jan 7;26(2):384-389.

Wang H, Loerke D, Bruns C, Müller R, Koch PA, Puchkov D, Schultz C, Haucke V. Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway. J Biol Chem. 2020 Jan 24;295(4):1091-1104.

Dziuba D, Hoffmann JE, Hentze MW, Schultz C. A Genetically Encoded Diazirine Analogue for RNA-Protein Photo-crosslinkingChembiochem. 2020;21(1-2):88-93.

Hagner M, Frey DL, Guerra M, Dittrich AS, Halls VS, Wege S, Herth FJF, Schultz C, Mall MA. New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometryEur Respir J. 2020;55(4):1902355. Published 2020 Apr 30.

Basappa J, Citir M, Zhang Q, Wang HY, Liu X, Melnikov O, Yahya H, Stein F, Muller R, Traynor-Kaplan A, Schultz C, Wasik MA, Ptasznik A. ACLY is the novel signaling target of PIP2/PIP3 and Lyn in acute myeloid leukemiaHeliyon. 2020;6(5):e03910. Published 2020 May 7.

Bittner T, Wittwer C, Hauke S, Wohlwend D, Mundinger S, Dutta AK, Bezold D, Dürr T, Friedrich T, Schultz C, Jessen HJ. Photolysis of Caged Inositol Pyrophosphate InsP8 Directly Modulates Intracellular Ca2+ Oscillations and Controls C2AB Domain LocalizationJ Am Chem Soc. 2020;142(24):10606-10611.

Morstein J, Dacheux MA, Norman DD, Shemet A, Donthamsetti PC, Citir M, Frank JA, Schultz C, Isacoff EY, Parrill AL, Tigyi GJ, Trauner D. Optical Control of Lysophosphatidic Acid SignalingJ Am Chem Soc. 2020;142(24):10612-10616.

Martin GM, Sung MW, Shyng SL. Pharmacological chaperones of ATP-sensitive potassium channels: Mechanistic insight from cryoEM structuresMol Cell Endocrinol. 2020;502:110667.

Jacobson DA, Shyng SL. Ion Channels of the Islets in Type 2 DiabetesJ Mol Biol. 2020;432(5):1326-1346.

Boodhansingh KE, Kandasamy B, Mitteer L, Givler S, De Leon DD, Shyng SL, Ganguly A, Stanley CA. Novel dominant KATP channel mutations in infants with congenital hyperinsulinism: Validation by in vitro expression studies and in vivo carrier phenotyping. Am J Med Genet A. 2019 Nov;179(11):2214-2227.

Balamurugan K, Kavitha B, Yang Z, Mohan V, Radha V, Shyng SL. Functional characterization of activating mutations in the sulfonylurea receptor 1 (ABCC8) causing neonatal diabetes mellitus in Asian Indian children. Pediatr Diabetes. 2019 Jun;20(4):397-407. 

Qiu J, Bosch MA, Zhang C, Rønnekleiv OK, Kelly MJ. Estradiol Protects Neuropeptide Y/Agouti-Related Peptide Neurons against Insulin Resistance in Females. Neuroendocrinology. 2020;110(1-2):105-118.

Heskett MB, Smith LG, Spellman P, Thayer MJ. Reciprocal monoallelic expression of ASAR lncRNA genes controls replication timing of human chromosome 6. RNA. 2020;26(6):724-738.

Licon MH, Yates PA. Purine-responsive expression of the Leishmania donovani NT3 purine nucleobase transporter is mediated by a conserved RNA stem-loopJ Biol Chem. 2020;295(25):8449-8459.

Hobbs SJ, Harbour JC, Yates PA, Ortiz D, Landfear SM, Nolz JC. Vaccinia Virus Vectors Targeting Peptides for MHC Class II Presentation to CD4+ T Cells. Immunohorizons. 2020;4(1):1-13. Published 2020 Jan 2.

Alwan KB, Welch EF, Blackburn NJ. Catalytic M Center of Copper Monooxygenases Probed by Rational Design. Effects of Selenomethionine and Histidine Substitution on Structure and Reactivity. Biochemistry. 2019 Nov 5; 58(44):4436-4446.

Alwan KB, Welch EF, Arias RJ, Gambill BF, Blackburn NJ. Rational Design of a Histidine-Methionine Site Modeling the M-Center of Copper Monooxygenases in a Small Metallochaperone Scaffold. Biochemistry. 2019 Jul 16;58(28):3097-3108.

Shi Z, Cassaglia PA, Pelletier NE, Brooks VL. Sex differences in the sympathoexcitatory response to insulin in obese rats: role of neuropeptide YJ Physiol. 2019;597(6):1757-1775.

Shi Z, Hansen KM, Bullock KM, Morofuji Y, Banks WA, Brooks VL. Resistance to the sympathoexcitatory effects of insulin and leptin in late pregnant ratsJ Physiol. 2019;597(15):4087-4100

Munnur D, Bartlett E, Mikolčević P, Kirby IT, Matthias Rack JG, Mikoč A, Cohen MS, Ahel I. Reversible ADP-ribosylation of RNA. Nucleic Acids Res. 2019 Jun 20;47(11):5658-5669. 

Šileikytė J, Devereaux J, de Jong J, Schiavone M, Jones K, Nilsen A, Bernardi P, Forte M, Cohen MSSecond-Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability. ChemMedChem. 2019 Sep 6.

Sharon F. Freedman, Charlotte Brennand, John Chiang, Andrea DeBarber, Monte A. Del Monte, P. Barton Duell, John Fiorito, Randall Marshall. Prevalence of Cerebrotendinous Xanthomatosis Among Patients Diagnosed With Acquired Juvenile-Onset Idiopathic Bilateral Cataracts. JAMA Ophthalmol. 2019 Sep 19;137(11):1312-1316.

Duvoisin RM, Ren G, Haley TL, Taylor MH, Morgans CW. TRPM1 Autoantibodies in Melanoma Patients Without Self-Reported Visual SymptomsInvest Ophthalmol Vis Sci. 2019;60(6):2330-2335.

Rønnekleiv OK, Qiu J, Kelly MJ. Arcuate Kisspeptin Neurons Coordinate Reproductive Activities with Metabolism. Semin Reprod Med. 2019 May;37(3):131-140.

Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL. Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM. Elife. 2019 Jul 25;8:e46417.

Cochrane V, Shyng SL. Leptin-induced Trafficking of KATP Channels: A Mechanism to Regulate Pancreatic β-cell Excitability and Insulin Secretion. Int J Mol Sci. 2019 May 30;20(11):2660.

Stincic TL, Rønnekleiv OK, Kelly MJMembrane and nuclear initiated estrogenic regulation of homeostasis. Steroids. 2019 Jun 20:108428.

Hartley MD, Banerji T, Tagge IJ, Kirkemo LL, Chaudhary P, Calkins E, Galipeau D, Shokat MD, DeBell MJ, Van Leuven S, Miller H, Marracci G, Pocius E, Banerji T, Ferrara SJ, Meinig JM, Emery B, Bourdette D, Scanlan TS. Myelin repair stimulated by CNS-selective thyroid hormone action. JCI Insight. 2019 Apr 18;4(8):e126329.

Meinig JM, Ferrara SJ, Banerji T, Banerji T, Sanford-Crane HS, Bourdette D, Scanlan TS. Structure-Activity Relationships of Central Nervous System Penetration by Fatty Acid Amide Hydrolase (FAAH)-Targeted Thyromimetic Prodrugs. ACS Med Chem Lett. 2018 Dec 4;10(1):111-116.

Chattergoon NN, Louey S, Scanlan T, Lindgren I, Giraud GD, Thornburg KL. Thyroid hormone receptor function in maturing ovine cardiomyocytes. J Physiol. 2019 Apr;597(8):2163-2176.

Smith TJ, Scanlan TS, Fernando R. Response to Letter to the Editor: "Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy". J Clin Endocrinol Metab. 2019 Apr 1;104(4):1077-1078. 

Hauke S, Dutta AK, Eisenbeis VB, Bezold D, Bittner T, Wittwer C, Thakor D, Pavlovic I, Schultz C, Jessen HJ. Photolysis of cell-permeant caged inositol pyrophosphates controls oscillations of cytosolic calcium in a β-cell line. Chem Sci. 2019;10(9):2687-2692. Published 2019 Jan 10.

Baser A, Skabkin M, Kleber S, Dang Y, Gülcüler Balta GS, Kalamakis G, Göpferich M, Ibañez DC, Schefzik R, Lopez AS, Bobadilla EL, Schultz C, Fischer B, Martin-Villalba A. Onset of differentiation is post-transcriptionally controlled in adult neural stem cellsNature. 2019;566(7742):100-104.

Laguerre A, Hauke S, Qiu J, Kelly MJ, Schultz C. Photorelease of 2-Arachidonoylglycerol in Live CellsJ Am Chem Soc. 2019;141(42):16544-16547

Mücksch F, Citir M, Lüchtenborg C, Glass B, Traynor-Kaplan A, Schultz C, Brügger B, Kräusslich HG. Quantification of phosphoinositides reveals strong enrichment of PIP2 in HIV-1 compared to producer cell membranes. Sci Rep. 2019;9(1):17661. Published 2019 Nov 27.

Guerra M, Frey D, Hagner M, Dittrich S, Paulsen M, Mall MA, Schultz C. Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow CytometryACS Cent Sci. 2019;5(3):539-548.

Ermakova YG, Mishina NM, Schultz C, Belousov VV. Visualization of Intracellular Hydrogen Peroxide with the Genetically Encoded Fluorescent Probe HyPer in NIH-3T3 Cells. Methods Mol Biol. 2019;1982:259-274.

Margaroli C, Garratt LW, Horati H, Dittrich AS, Rosenow T, Montgomery ST, Frey DL, Brown MR, Schultz C, Guglani L, Kicic A, Peng L, Scholte BJ, Mall MA, Janssens HM, Stick SM, Tirouvanziam R. Elastase Exocytosis by Airway Neutrophils Is Associated with Early Lung Damage in Children with Cystic Fibrosis. Am J Respir Crit Care Med. 2019 Apr 1;199(7):873-881.

Baser A, Skabkin M, Kleber S, Dang Y, Gülcüler Balta GS, Kalamakis G, Göpferich M, Ibañez DC, Schefzik R, Lopez AS, Bobadilla EL, Schultz C, Fischer B, Martin-Villalba A. Onset of differentiation is post-transcriptionally controlled in adult neural stem cells. Nature. 2019 Feb;566(7742):100-104.

Riederer EA, Valiyaveetil FI. Investigation of the allosteric coupling mechanism in a glutamate transporter homolog via unnatural amino acid mutagenesisProc Natl Acad Sci U S A. 2019;116(32):15939-15946.

McDonald SK, Levitz TS, Valiyaveetil FI. A Shared Mechanism for the Folding of Voltage-Gated K+ ChannelsBiochemistry. 2019;58(12):1660-1671

Jiang M, Yan Y, Yang K, Liu Z, Qi J, Zhou H, Qian N, Zhou Q, Wang T, Xu X, Xiao X, Deng L. Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis. J Cell Mol Med. 2019 Feb;23(2):1224-1234. 

Slaker ML, Jorgensen ET, Hegarty DM, Liu X, Kong Y, Zhang F, Linhardt RJ, Brown TE, Aicher SA, Sorg BA. Cocaine Exposure Modulates Perineuronal Nets and Synaptic Excitability of Fast-Spiking Interneurons in the Medial Prefrontal Cortex. eNeuro. 2018 Oct 4;5(5). pii: ENEURO.0221-18.2018. 

Hegarty DM, Hermes SM, Morgan MM, Aicher SA (2018) Acute hyperalgesia and delayed dry eye after corneal abrasion injury. Pain Reports June 20, 2018 

Mohammed M, Madden CJ, Andresen MC, Morrison SF. Activation of TRPV1 in nucleus tractus solitarius reduces brown adipose tissue thermogenesis, arterial pressure, and heart rate. Am J Physiol Regul Integr Comp Physiol. 2018 Jul 1;315(1):R134-R143. 

Komegae EN, Farmer DGS, Brooks VL, McKinley MJ, McAllen RM, Martelli D. Vagal afferent activation suppresses systemic inflammation via the splanchnic anti-inflammatory pathway. Brain Behav Immun. 2018 Oct;73:441-449. 

Chacón KN, Perkins J, Mathe Z, Alwan K, Ho EN, Ucisik MN, Merz KM, BlackburnNJ. Trapping intermediates in metal transfer reactions of the CusCBAF export pump of Escherichia coli. Commun Biol. 2018 Nov 14

Carter-O’Connell, I.O., Vermehren-Schmaedick, A, Jin, H, Haihong Jin, Morgan, R.K., David, L.L., Cohen, M.S Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14)., ACS Chemical Biology, Article ASAP (2018).

Kirby, I.T. and Cohen, M.S. "Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapuetics." Current Topics in Microbiology and Immunology, (2018). Cohen, M.S. and Chang, P. “Insights into the biogenesis, function, and regulation of ADP-ribosylation,” Nature Chemical Biology, 14, 236 (2018). 

Cohen, M.S., Stewart, M.L., Goodman, R.H., Cambronne, X.A. “Methods for using a genetically encoded fluorescent biosensor to monitor nuclear NAD,” Methods in Molecular Biology, 1813, 391 (2018).  Kirby, I.T., Morgan, R.K., and Cohen, M.S. “A simple, sensitive, and generalizable plate assay for screening PARP inhibitors,” Methods in Molecular Biology, 1813, 245 (2018).  

DeBarber AE, Kalfon L, Fedida A, Fleisher Sheffer V, Ben Haroush S, Chasnyk N, Shuster Biton E, Mandel H, Jeffries K, Shinwell ES, Falik-Zaccai TC. Newborn screening for cerebrotendinous xanthomatosis is the solution for early identification and treatment. J Lipid Res. 2018 Nov;59(11):2214-2222.

Torres ERS, Akinyeke T, Stagaman K, Duvoisin RM, Meshul CK, Sharpton TJ, Raber J. Effects of Sub-Chronic MPTP Exposure on Behavioral and Cognitive Performance and the Microbiome of Wild-Type and mGlu8 Knockout Female and Male Mice. Front Behav Neurosci. 2018 Jul 18;12:140.   

Denfeld, Q.E., Habecker B.A., and Woodward, W.R. (2018) Measurement of Plasma Norepinephrine and 3,4-Dihydroxyphenylglycol: Method Development for a Translational Research Study. BMC Research Notes, 11(1):248. 

Bayles R.G., Olivas A., Denfeld Q., Woodward W.R., Fei S.S., Gao L., Habecker B.A. (2018) Transcriptomic and neurochemical analysis of the stellate ganglia in mice highlights sex differences. Scientific Reports, 8(1):8963. d

Francis Stuart SD, Wang L, Woodard WR, Ng GA, Habecker BA, Ripplinger CM. Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation. J Physiol. 2018 Jun 25. doi: 10.1113/JP276396. [Epub ahead of print] PubMed PMID: 29938794.Veruki ML, Zhou Y, Castilho Á, Morgans CW, Hartveit E. Extrasynaptic NMDA receptors on rod pathway amacrine cells: molecular composition, activation, and signaling. J Neurosci. 2018 Nov 20. pii: 2267-18. 

Stincic TL, Grachev P, Bosch MA, Rønnekleiv OKKelly MJEstradiol Drives the Anorexigenic Activity of Proopiomelanocortin Neurons in Female Mice. eNeuro. 2018 Oct 10;5(4). pii: ENEURO.0103-18.2018. 

Vazquez MJ, Toro CA, Castellano JM, Ruiz-Pino F, Roa J, Beiroa D, Heras V, Velasco I, Dieguez C, Pinilla L, Gaytan F, Nogueiras R, Bosch MA, Rønnekleiv OK, Lomniczi A, Ojeda SR, Tena-Sempere M. SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression. Nat Commun. 2018 Oct 10;9(1):4194. 

Qiu J, Bosch MA, Meza C, Navarro UV, Nestor CC, Wagner EJ, Rønnekleiv OKKelly MJEstradiol Protects Proopiomelanocortin Neurons Against Insulin Resistance. Endocrinology. 2018 Feb 1;159(2):647-664. 

Kelly MJ, Qiu J, Rønnekleiv OK.TRPCing around the hypothalamus. Front Neuroendocrinol. 2018 May 31. pii: S0091-3022(18)30042-6. 

Scully CM, Estill CT, Amodei R, McKune A, Gribbin KP, Meaker M, Stormshak F, Roselli CEEarly prenatal androgen exposure reduces testes size and sperm concentration in sheep without altering neuroendocrine differentiation and masculine sexual behavior. Domest Anim Endocrinol. 2018 Jan;62:1-9. 

Roselli CENeurobiology of gender identity and sexual orientation. J Neuroendocrinol. 2018 Jul;30(7):e12562. 

Heck AL, Crestani CC, Fernández-Guasti A, Larco DO, Mayerhofer A, Roselli CENeuropeptide and steroid hormone mediators of neuroendocrine regulation. J Neuroendocrinol. 2018 Apr 12:e12599. 

Devereaux J, Ferrara SJ, Scanlan TSQuantification of Thyromimetic Sobetirome Concentration in Biological Tissue Samples. Methods Mol Biol. 2018;1801:193-206. 

Kath, C., Mueller, R., Schultz, C., Haucke, V., Eickholt, B., Schmoranzer, J. PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules. PLoS One 13, e0193257 (2018). 

Hauke, S., Keutler, K., Yushchenko, D., Schultz, CEndogenous Fatty Acids are Essential Autocrine Signaling Factors of Pancreatic β-Cells and Insulin Secretion. Diabetes 67, (2018). 

Hoffmann, J.-E., Dziuba, D., Stein, F., Schultz, CA bifunctional noncanonical amino acid: synthesis, expression and residue-specific proteome-wide incorporation. Biochemistry (2018). In press

Frank, J., Broichhagen, J., Yushchenko, D., Trauner, D.,  Schultz, C., Hodson, D. Optical tools for understanding the complexity of beta cell signaling and insulin release. Nat. Rev. Endocrinol. (2018) accepted

Laguerre A, Schultz CNovel lipid tools and probes for biological investigations. Curr Opin Cell Biol. 2018 Aug;53:97-104. 

Kirby, I. T., Kojic, A., Arnold, M. R., Thorsell, A.-G., Karlberg, T., Vermehren-Schmaedick, A., Sreenivasan, R., Schultz, C., Schüler, H., Cohen M. S.  A potent and selective PARP11 inhibitor suggests coupling between cellular localization and catalytic activity. Cell Chem. Biol. (2018). accepted

Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S, Belaaouaj A, Dalpke AH, Schultz C, Mall MA. Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease. Am J Respir Crit Care Med. 2014 May 1;189(9):1082-92. 

Infield DT, Matulef K, Galpin JD, Lam K, Tajkhorshid E, Ahern CA, Valiyaveetil FIMain-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor. Nat Commun. 2018 Nov 29;9(1):5055. 

Matulef K, Valiyaveetil FIPatch-Clamp Recordings of the KcsA K(+) Channel in Unilamellar Blisters. Methods Mol Biol. 2018;1684:181-191. 

Riederer EA, Focke PJ, Georgieva ER, Akyuz N, Matulef K, Borbat PP, Freed JH, Blanchard SC, Boudker O, Valiyaveetil FIA facile approach for the in vitro assembly of multimeric membrane transport proteins. Elife. 2018 Jun 11;7. pii: e36478. 

Jiang M, Yan Y, Yang K, Liu Z, Qi J, Zhou H, Qian N, Zhou Q, Wang T, Xu X, Xiao X, Deng L. Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis. J Cell Mol Med. 2018 Nov 20. 

Li, B. X.;* Chen, J.; Chao, B.; David, L; Xiao, X. "A lamin-binding ligand LBL1 targets nuclear lamins", ACS Chem. Biol., 2018, 13, 1380-1387. 

Li, B. X.;* Chen, J.;Chao, B.;Zheng, Y.;Xiao, X.* "A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks" ACS Cent. Sci. 2018.

Sanford-Crane, H.; Pejovic, T.; Xiao, X. "Drugging Homologous Recombination: Back to the Future" Future Medicinal Chemistry, 2018, 10, 1279-1281.

Meng, Q.;Li, B. X.; Xiao, X. "Towards Developing Chemical Modulators of Hsp60 as Potential Therapeutics" Front. Mol. Biosci., 2018.

Winters BL, Gregoriou GC, Kissiwaa SA, Wells OA, Medagoda DI, Hermes SM, Burford NT, Alt A, Aicher SA, Bagley EE. Endogenous opioids regulate moment-to-moment neuronal communication and excitability. Nat Commun. 2017 Mar 22;8:14611. 

Hegarty DM, Hermes SM, Yang K, Aicher SASelect noxious stimuli induce changes on corneal nerve morphology. J Comp Neurol. 2017 Jun 1;525(8):2019-2031. 

McDougall SJ, Guo H, Andresen MCDedicated C-fibre viscerosensory pathways to central nucleus of the amygdala. J Physiol. 2017 Feb 1;595(3):901-917. 

Hofmann ME, Andresen MCDynasore blocks evoked release while augmenting spontaneous synaptic transmission from primary visceral afferents. PLoS One. 2017 Mar 30;12(3):e0174915.  

Beaumont E, Campbell RP, Andresen MC, Scofield S, Singh K, Libbus I, KenKnight BH, Snyder L, Cantrell N. Cervical vagus nerve stimulation augments spontaneous discharge in second- and higher-order sensory neurons in the rat nucleus of the solitary tract. Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H354-H367. 

Shi Z, Madden CJ, Brooks VLArcuate neuropeptide Y inhibits sympathetic nerve activity via multiple neuropathways. J Clin Invest. 2017 Jun 30;127(7):2868-2880.   

Morgan, R.K, and Cohen, M.S. “Detecting protein ADP-ribosylation using a clickable aminooxy probe,” Methods in Molecular Biology, 1601, 71 (2017).

Cohen, M.S. “Axon Degeneration: Too Much NMN is Actually Bad,” Current Biology, 27, R310 (2017).

Thorsell, A.G., Ekblad, T. Karlberg, T., Low, M., Pinto, A.F., Tresaugues, L., Moche, M.,Cohen, M.S., and Schuler, H. “Structural Basis for Potency and Promiscuity in Poly)ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors,” Journal of Medicinal Chemistry, 60, 1262 (2017).

Cambronne, X.A.*,Stewart, M.L., Kim, D., Jones-Brunette, A.M., Morgan, R.K., Farrens, D.L.,Cohen, M.S.*, Goodman, R.H. "Biosensor reveals multiple sources for mitochondrial NAD+," Science 352, 1474 (2016). *corresponding authors Featured in: Perspectives: Science, 352, 1396 (2017) and Research Highlights: Nature Methods, 13, 610 (2017)

Hitchcock P, Mathur A, Bennett J, Cameron P, Chow C, Clifford P, Duvoisin R, Feig A, Finneran K, Klotz DM, McGee R, O'Riordan M, Pfund C, Pickett C, Schwartz N, Street NE, Watkins E, Wiest J, Engelke D. The future of graduate and postdoctoral training in the biosciences. Elife. 2017 Oct 19;6. pii: e32715.  

Duvoisin RM, Haley TL, Ren G, Strycharska-Orczyk I, Bonaparte JP, Morgans CWAutoantibodies in Melanoma-Associated Retinopathy Recognize an Epitope Conserved Between TRPM1 and TRPM3. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2732-2738. 

Vaseghi, M., Yagishita, D., Rajendran, P.J., Woodward, W.R., Hamon, D., Yamakawa, K., Irie, T., Habecker B.A., and Shivkumar, K.Parasympathetic Dysfunction and Mechanistic Basis of Anti-arrhythmic Effects of Vagal Nerve Stimulation Following Myocardial Infarction.  JCI Insight. 2017 Aug 17;2(16). pii: 86715. 

Murphy, S.R., Wang, L., Wang, Z., Domondon, P., Lang, D., Habecker, B.A., Myles, R.C., and Ripplinger, C.M. (2017) β-adrenergic inhibition prevents action potential and calcium handling changes during regional myocardial ischemia.  Frontiers in Physiology, Aug 28;8:630. 

Parrish, D.C., Olivas, A., Francis Stuart, S.D., Wang, L., Nykjaer, A., Ripplinger, C.M., and Habecker, B.A. (2018) Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility. AJP:Heart and Circulatory Physiology. 314(3):H415-H423. 

Padilla SL, Qiu J, Nestor CC, Zhang C, Smith AW, Whiddon BB, Rønnekleiv OKKelly MJ, Palmiter RD. AgRP to Kiss1 neuron signaling links nutritional state and fertility. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2413-2418. 

Asquith M, Davin S, Stauffer P, Michell C, Janowitz C, Lin P, Ensign-Lewis J, Kinchen JM, Koop DR, Rosenbaum JT. Intestinal Metabolites Are Profoundly Altered in the Context of HLA-B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis. Arthritis Rheumatol. 2017 Oct;69(10):1984-1995. 

Al-Uzri A, Freeman KA, Wade J, Clark K, Bleyle LA, Munar M, Koop DRLongitudinal study on the use of dried blood spots for home monitoring in children after kidney transplantation. Pediatr Transplant. 2017 Sep;21(6). 

Frueh L, Li Y, Mather MW, Li Q, Pou S, Nilsen A, Winter RW, Forquer IP, Pershing AM, Xie LH, Smilkstein MJ, Caridha D, Koop DR, Campbell RF, Sciotti RJ, Kreishman-Deitrick M, Kelly JX, Vesely B, Vaidya AB, Riscoe MK. Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria. ACS Infect Dis. 2017 Oct 13;3(10):728-735. 

Mirto AJ, Austin KJ, Uthlaut VA, Roselli CE, Alexander BM. Fos Expression in the Olfactory Pathway of High- and Low-Sexually Performing Rams Exposed to Urine from Estrous or Ovariectomized Ewes. Appl Anim Behav Sci. 2017 Jan;186:22-28. 

Kramer AC, Mirto AJ, Austin KJ, Roselli CE, Alexander BM. Tyrosine hydroxylase in the ventral tegmental area of rams with high or low libido-A role for dopamine. Anim Reprod Sci. 2017 Dec;187:152-158. 

Meinig JM, Ferrara SJ, Banerji T, Banerji T, Sanford-Crane HS, Bourdette D, Scanlan TS. Targeting Fatty-Acid Amide Hydrolase with Prodrugs for CNS-Selective Therapy. ACS Chem Neurosci. 2017 Nov 15;8(11):2468-2476. 

Yu, X., Akbarzadeh, R., Pieper, M., Scholzen, T., Gehrig, S., Schultz, C., Zillikens, D., König, P., Petersen, F. Neutrophil adhesion is a prerequisite for antibody-mediated proteolytic tissue damage in experimental models of epidermolysis bullosa acquisita. J. Invest. Dermatol. (2018). 

Marat, A., Wallroth, A., Lo, W.-T., Mueller, R., Norata, G. D., Falasca, M., Schultz, C., Haucke, V. "Phosphatidylinositol 3,4-bisphosphate represses nutrient signaling by mTORC1" Science 356, 968-972 (2017).

Frank,, J. A., Yushchenko, D. A., Fine, N. H. F., Duca, M., Citir, M., Broichhagen, J., Hodson, D. J., Schultz, C., Trauner, D. Optical control of GPR40 signalling in pancreatic ß-cells. Chem. Sci. 8, 7604-7610 (2017). 

Müksch, F., Laketa, V., Müller, B., Schultz, C., Kräusslich, H.-G. Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring. eLife 6, e25287 (2017).

Zuidscherwoude, M., Dunlock, V.-M. E., van den Bogaart, G., van Deventer, S.J., van der Schaaf, A., van Oostrum, J., Goedhart, J., In 't Hout, J., Hämmerling, G. J., Tanaka, S., Nadler, A., Schultz, C., Wright, M. D., Adjobo-Hermans, M. J. W., van Spriel, A. B. Tetraspanin microdomains control localized protein kinase C signaling in B cells. Sci. Signal. 10, eaag2755 (2017).

Walter*, A., Mueller, R., Wierda, K. D. B., Tawfik, B., Pinheiro, P. S., Nadler, A., Ziomkiewicz, I., Kruse, M., Reither, G., Rettig, J., Haucke, V., Hille, B., Schultz*, C., Soerensen*, J. Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis, eLife 6, e30203 (2017). 

Dittrich, A. S., Kuehbandner, I., Gehrig, S., Rickert-Zacharias, V., Twigg, M., Wege, S., Taggert, C., Herth, F., Schultz, C., Mall, M. Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis. Eur. Resp. J. 29, pii 1701910 (2018). 

Bogdanova, Y. A., Schultz, C., Belousov, V. V. Local Generation and Imaging of Hydrogen Peroxide in Living Cells. Curr. Protocols Chem. Biol. 9, 117-127 (2017)

Kratochvil HT, Maj M, Matulef K, Annen AW, Ostmeyer J, Perozo E, Roux B, Valiyaveetil FI, Zanni MT. Probing the Effects of Gating on the Ion Occupancy of the K(+) Channel Selectivity Filter Using Two-Dimensional Infrared Spectroscopy. J Am Chem Soc. 2017 Jul 5;139(26):8837-8845. 

Valiyaveetil FIA glimpse into the C-type-inactivated state for a Potassium Channel. Nat Struct Mol Biol. 2017 Oct 5;24(10):787-788.