The Center for ADHD Research engages and utilizes resources collaboratively with world-class core facilities at OHSU:
Center faculty members are actively engaged in national and international research consortia to leverage our data and expertise with others working on ADHD.
These consortia enable analysis of very large data sets that can answer questions not possible in local, single-institution studies. These efforts complement the deeper dive studies on particular topics the consortium does uniquely at OHSU.
Among these collaborative consortia are the following:
The Psychiatric Genomics Consortium
This is one of the largest experiments in the history of psychiatry. The central idea of the PGC is leveraging global collaboration to advance genetic discovery of biologically, clinically, and therapeutically meaningful insights. Our focus in particular is on our participation in the Attention Deficit Hyperactivity Disorder Workgroup, a worldwide collaboration to discover genetic influences on ADHD.
The ENIGMA Consortium
This network brings together researchers in imaging genomics to understand brain structure, function, and disease, based on brain imaging and genetic data. Here again, our primary focus is our active collaboration with ENIGMA ADHD. The ENIGMA ADHD working group aims to carry out mega- and Meta-Analysis of existing brain imaging (MRI) data of children and adults with ADHD and non-ADHD controls. At this time we have included data from 34 cohorts around the world with over 4,000 participants.
The Adolescent Brain and Cognitive Development study (ABCD)
This project is the largest long-term study of brain development and child health in the United States. Nearly 11,000 children representing the United States population, from 21 sites around the country, are undergoing annual evaluation and MRI brain imaging. Genetic and clinical data as well as a host of environmental exposure variables are obtained. We are one of the sites and our investigators actively participate in data analysis and writing.
The International Consortium for the Study of DNA Methylation Epigenetics in ADHD
This group of investigators from multiple sites is pooling data on DNA methylation in children and adults with ADHD. DNA methylation is a type of chemical attachment to the DNA that changes gene expression, and can be a clue to environmental influences on ADHD.
We also collaborate with outside partners on particular technically demanding analyses. These include: