Skye C. Mayo M.D., M.P.H., F.A.C.S.

Photo of Skye C. Mayo, M.D., M.P.H., F.A.C.S.
Faculty profile
  • Assistant Professor of Surgery, Division of Surgical Oncology

Assistant Professor of Surgery, Division of Surgical Oncology School of Medicine

Accepting new patients

4.8 out of 5 (153 Ratings, 50 Comments)


  • Cancer
  • Surgery

Special focus on

  • Biliary Tract Cancer
  • Liver Cancer
  • Metastatic Colorectal Cancer
  • Pancreatic Cancer
  • Retroperitoneal Sarcoma


  • M.D., Oregon Health & Science University School of Medicine 2006
  • M.P.H., Oregon Health & Science University School of Public Health and Preventive Medicine 2006
  • Internship:

    • General Surgery, The Johns Hopkins Hospital, 2006
  • Residency:

    • General Surgery, The Johns Hopkins Hospital, 2013
  • Fellowship:

    • Cancer Immunology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medical Institutions, 2011
    • Complex General Surgical Oncology, Hepatopancreatobiliary Focus, Memorial Sloan-Kettering Cancer Center, 2013-15
  • Certifications:

    • American Board of Surgery, General Surgery, 2013
    • American Board of Surgery, Complex General Surgical Oncology, 2016


Dr. Skye Mayo is board certified in both Complex General Surgical Oncology and in General Surgery. His clinical practice serves patients with tumors of the liver, bile ducts, and pancreas. He also treats patients with gall bladder cancer, cancers of the stomach and digestive system, and retroperitoneal sarcomas.  His research focuses on helping patients with cancers that have spread to or arise in the liver, such as colorectal cancer and intrahepatic cholangiocarcinoma.

Dr. Mayo is an Oregon native: born in Eastern Oregon and raised in Central Oregon. During his surgical residency at Johns Hopkins his clinical and research work focused on the treatment of patients with pancreatic and liver cancers.  He completed a research fellowship in Cancer Immunology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins investigating the role of immune therapy in patients with metastatic liver disease. His surgical oncology fellowship at Memorial Sloan-Kettering Cancer Center in New York was focused in advanced Hepatopancreatobiliary Surgery where he was also certified to perform robotic cancer operations.

He is a member of a talented team of surgeons and oncologists at OHSU where he uses his experience and research to help advance the treatment of patients with cancers of the liver, bile ducts, and pancreas.  He is a member of the OHSU Knight Cancer Institute and of the Southwest Oncology Group, which offers patients the latest in cancer care through participation in clinical trials. His research at OHSU involves using hepatic arterial regional therapy for patients with liver and bile duct cancers and investigating how to harness the immune system to fight cancer. Specifically, his research efforts are directed toward the early detection of recurrent cancer and monitoring responses to treatment in patients with colorectal cancer metastatic to the liver.

Dr. Mayo views it as a privilege to work with patients, their families, and primary care doctors to develop the best treatment plans. He is dedicated to offering the highest quality of service. He looks forward to working with other cancer specialists to help give his patients the most options and the best possible outcome.

Read more


  • English

Memberships and associations

  • Society of Surgical Oncology (SSO)
  • Americas Hepato Pancreato Biliary Association (AHPBA)
  • American Society of Clinical Oncology (ASCO)
  • Connective Tissue Oncology Society (CTOS, Sarcoma)
  • American Association of Cancer Research (AACR)
  • Johns Hopkins Surgery, Old Hands Club
  • American College of Surgeons
  • North Pacific Surgical Association
  • Portland Surgical Society
  • Mackenzie Surgical Society
  • Alpha Omega Alpha (AOA) Medical Honor Society
  • SWOG (Southwest Oncology Group) Surgery and Gastrointestinal Oncology Committee Member
  • Trans Atlantic Retroperitoneal Sarcoma Working Group (TARPSWG), Member

Patient Ratings

4.8 out of 5 (153 Ratings, 50 Comments)

The patient ratings score is an average of all responses to the question "How likely would you be to recommend this provider to your family and friends (on a scale of 0 to 10)" on our nationally-recognized NRC patient surveys.

Patient Comments

  • May 04, 2019

    Both Dr. Mayo and Dr. Pasko are quite lovely and always make sure I feel heard and seen. I know they care about me.

  • Apr 25, 2019

    It didn't go as I wanted it to, but I understand his reasoning

  • Apr 18, 2019

    Dr Mayo is amazing. He is informative, caring, very thorough and compassionate. I always leave knowing I’m in the best hands with him.

  • Apr 18, 2019

    Dr. Skye and staff are amazing in every way. I feel like royalty every visit and or interaction with them. They are a blessing to us.

  • Apr 12, 2019

    My visit with Dr Mayo was outstanding, getting great news that my cancer is gone. Dr Mayo and his Team are fabulous.My experience with OHSU and OHHU has been the best care I could ever have. Thank you Thank You Thank you

  • Apr 11, 2019

    We love him. He’s thorough and covers all the information to make sure you understand. For a surgeon he has a wonderful bedside manner. I have no complaints against him or any of his staff. They are all great,

  • Apr 04, 2019

    Dr Mayo explains everything thoroughly and made sure we understood exactly what procedures were going to take place. He never made us feel rushed, and even checked back in on us as we were waiting for his assistant to come speak with us about the surgery.

  • Apr 01, 2019

    Excellent care

  • Mar 15, 2019

    Very caring communicative and competent physician and staff

  • Mar 05, 2019

    Dr Mayo and his team have addressed my concerns and helped me to understand the procedure to be performed. I have confidence in his expertise and skill.

  • Feb 16, 2019

    I was treated... in a friendly, timely, and courteous manner, and... all the providers seemed to be very... knowledgeable, and informed me very well about my situation.

  • Feb 08, 2019

    I felt very confident with him and his...I don't know whether she's another intern or just another doctor that he had with him. I thought they were both very professional and...and very interested my process and were making sure that I got the best care so I was very happy with it.

  • Feb 02, 2019

    Upfront, gentle, kind, realistic. Honest

  • Jan 31, 2019

    Prompt, courteous, and efficient

  • Jan 25, 2019

    Very competent and compassionate

  • Dec 31, 2018

    Dr. Mayo, Rachel and The Whole Team are Amazing in every way! I am forever Grateful for their Care of me!! Thank you!

  • Dec 29, 2018

    He was informative and honest

  • Dec 28, 2018

    My surgical oncologist is Dr. Skye Mayo. Dr. Mayo is the best doctor I have ever had. He is communicative and compassionate. He and his staff (special kudos to [Name] have made my journey much easier to bear.

  • Dec 28, 2018

    Dr Mayo is thorough, considerate and informative. He is careful to go through all the information and answer any questions I might have. His confidence makes me feel like I'm in very good hands.

  • Dec 27, 2018

    One of the best. He is a person who truly cares about his patients.

  • Dec 22, 2018

    He's a very good doctor, caring, he's passionate about his work, and he's always there for you, and he does a great job.

  • Dec 21, 2018

    Good communicator and compassionate care giver. Has great staff around him

  • Dec 21, 2018

    Great personal attention. Caring. Pro-active.Informed. Action plan.

  • Dec 14, 2018

    The doctor was very competent. He answered my questions. I had hoped that he would tell me that the surgery would solve all the problems. I am happy I got a second oppion. I would have hated to have surgery, and still have the problems.

  • Nov 30, 2018

    Dr Mayo was informative and is making sure I have the neccessary support system in place before scheduling my surgical procedure.

  • Nov 12, 2018

    Dr. Mayo is very, very considerate. Remote travelers in our time and everything to get there and back. He explains everything to us so, so thoroughly. He makes us feel so comfortable. I can't say enough nice things about him, but it's been enjoy.... even during a rough situation, it's been a joy. Thank you.

  • Nov 09, 2018

    Okay. We have always found Dr. Skye Mayo and his staff to be very, very knowledgeable, helpful, informative. Very pleased with the care we received, or I received, and highly recommend them to anyone and everyone. And can't say enough good things about OHSU and Dr. Skye Mayor and his staff. Thank you.

  • Nov 09, 2018

    I would like to thank Dr Mayo, staff and students for all they did to help get through surgery, the care I received was awesome!!!!!!

  • Nov 09, 2018

    Dr. Mayo has wonderful bed side manner, he explains everything so you have an understanding of what's happening, and test results and what to expect, and very knowledgeable about the type of cancer that I was dealing with.

  • Nov 09, 2018

    Professional listen knowledgable, understanding

  • Nov 03, 2018

    Dr. Mayo is very communicative. He spent some time with both myself and my family members that were there. He also called me back at home about some test results, and I think he performs very well.

  • Oct 19, 2018

    I can?t possibly imagine getting the opportunity to deal with doctors and staff that are more compassionate and informative than what I experienced at OHSU , it truly is a great experience when coming there!

  • Oct 15, 2018

    Dr. Mayo is always professional and compassionate. He is what all doctors should be.

  • Sep 28, 2018

    Dr Mayo and staff are both knowledgeable and kind, I feel like I'm in the best of hands.

  • Sep 06, 2018

    Dr Mayo is a great one of a kind doctor

  • Sep 01, 2018

    Professional, very helpfull,.

  • Sep 01, 2018

    My experience at OHSU was exceptional. I was given a thorough work-up and examination by Dr. Skye Mayo and his HPB fellow, Dr. Lauren Wancata. The medical and family history taken by them was more detailed than any I had had before. Dr. Mayo's coordinator, Rachel Schafer, then worked to make a number of lab and CT scan appointments for me.

  • Aug 09, 2018

    Dr. Mayo and his staff have always been very helpful and professional. They, collectively, have fully satisfied my needs.

  • Aug 09, 2018

    Dr Mayo is always positive and caring. He takes time to answer my questions.

  • Aug 09, 2018

    Dr. Mayo was totally familiar with my chart. He truly cared about what is best for me. He listened attentively and clearly answered questions fully.

  • Aug 06, 2018

    Very knowledgeable and personable

  • Aug 03, 2018

    Dr. Mayo is very communicative, answered my questions, and was very patient answering my wife and son's questions.

  • Aug 02, 2018


  • Aug 01, 2018

    I think Dr Mayo is the best, kind and caring and a awesome surgeon

  • Jul 26, 2018

    This is by far the best hospital I have ever stepped foot in, the staff are beyond professional and make you feel as if you are being cared for in the absolute best manner possible! Can?t say enough good things about OHSU

  • Jul 13, 2018

    They?re amazing with their knowledge. Kind a responsive

  • Jul 13, 2018

    He was very nice and informative and confident. Thank you.

  • Jul 13, 2018

    Great care. Compassionate Doctors. Efficient staff.

  • Jun 20, 2018

    I appreciate that Dr. Mayo was able to clearly and early in the visit clearly state I had no issues. Getting that out of the way immediately greatly reduced my stress.

  • May 16, 2018