Photo of Thomas R. Shearer, Ph.D.

Thomas R. Shearer Ph.D.

  • (503) 494-8770

    Portland Campus

    • Professor of Integrative Biosciences School of Dentistry
    • Biochemistry and Molecular Biology Graduate Program School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Areas of interest

  • biochemistry
  • nutrition
  • statistics
  • pharmacology

Publications

  • "Contribution of calpain and caspases to cell death in cultured monkey RPE cells." Investigative Ophthalmology and Visual Science  In: , Vol. 58, No. 12, 01.10.2017, p. 5412-5420.
  • "In Silico Ocular Pharmacokinetic Modeling : Delivery of Topical FK962 to Retina." Journal of Ocular Pharmacology and Therapeutics  In: , Vol. 33, No. 7, 01.09.2017, p. 556-566.
  • "Selecting fuchs patients for drug trials involving endothelial cell proliferation." European Journal of Ophthalmology  In: , Vol. 26, No. 6, 01.11.2016, p. 536-539.
  • "FK962 induces neurite outgrowth in cultured monkey trigeminal ganglion cells." Graefe's Archive for Clinical and Experimental Ophthalmology  In: , 24.10.2016, p. 1-6.
  • "Galectin-3 enhances extracellular matrix associations and wound healing in monkey corneal epithelium." Experimental Eye Research  In: , Vol. 137, 01.08.2015, p. 71-78.
  • "Serum antibodies against βH-crystallins in the American Cocker Spaniel." Veterinary Ophthalmology  In: , Vol. 18, No. 2, 01.03.2015, p. 109-115.
  • "Hypoxia activates calpains in the nerve fiber layer of monkey retinal explants." Investigative Ophthalmology and Visual Science  In: , Vol. 56, No. 10, 2015, p. 6049-6057.
  • "Loss of calpastatin leads to activation of calpain in human lens epithelial cells." Investigative Ophthalmology and Visual Science  In: , Vol. 55, No. 8, 22.07.2014, p. 5278-5283.
  • "Dry eye in LASIK patients." BMC Research Notes  In: , Vol. 7, No. 1, 420, 03.07.2014.
  • "Mechanism for laser-induced neovascularization in rat choroid : Accumulation of integrin α chain-positive cells and their ligands." Molecular Vision  In: , Vol. 20, 19.06.2014, p. 864-871.
  • "Degeneration and dysfunction of retinal neurons in acute ocular hypertensive rats : Involvement of calpains." Journal of Ocular Pharmacology and Therapeutics  In: , Vol. 30, No. 5, 01.06.2014, p. 419-428.
  • "Galectin-3 enhances epithelial cell adhesion and wound healing in rat cornea." Ophthalmic Research  In: , Vol. 51, No. 2, 01.2014, p. 96-103.
  • "Activation of the mitochondrial caspase pathway and subsequent calpain activation in monkey RPE cells cultured under zinc depletion." Eye (Basingstoke)  In: , Vol. 28, No. 1, 01.2014, p. 85-92.
  • "Calpain protease causes hypoxia-induced proteolysis in cultured human Retina." Current Eye Research  In: , Vol. 39, No. 4, 2014, p. 421-424.
  • "Involvement of NFκB in the production of chemokines by rat and human conjunctival cells cultured under allergenic conditions." Current Eye Research  In: , Vol. 38, No. 8, 08.2013, p. 825-834.
  • "Pituitary adenylate cyclase-activating peptide induces neurite outgrowth in cultured monkey trigeminal ganglion cells : Involvement of receptor PAC1." Molecular Vision  In: , Vol. 19, 28.01.2013, p. 174-183.
  • "Concerted inhibition of HIF-1α and -2α expression markedly suppresses angiogenesis in cultured RPE cells." Molecular and Cellular Biochemistry  In: , Vol. 383, No. 1-2, 2013, p. 113-122.
  • "Lacritin-induced secretion of tear proteins from cultured monkey lacrimal acinar cells." Investigative Ophthalmology and Visual Science  In: , Vol. 54, No. 4, 2013, p. 2533-2540.
  • "FK962 promotes neurite elongation and regeneration of cultured rat trigeminal ganglion cells : Possible involvement of GDNF." Investigative Ophthalmology and Visual Science  In: , Vol. 53, No. 9, 08.2012, p. 5312-5319.
  • "Involvement of calpain 2 in ionomycin-induced cell death in cultured mouse lens epithelial cells." Current Eye Research  In: , Vol. 36, No. 10, 10.2011, p. 930-936.
  • "Calpain, not caspase, is the causative protease for hypoxic damage in cultured monkey retinal cells." Investigative Ophthalmology and Visual Science  In: , Vol. 52, No. 10, 09.2011, p. 7059-7067.
  • "Mechanism for carbachol-induced secretion of lacritin in cultured monkey lacrimal acinar cells." Investigative Ophthalmology and Visual Science  In: , Vol. 51, No. 9, 09.2010, p. 4395-4406.
  • "Patient selection criteria for pilot studies on amelioration of non-neovascular age-related macular degeneration." Journal of Ocular Pharmacology and Therapeutics  In: , Vol. 26, No. 4, 01.08.2010, p. 367-371.
  • "Human and monkey lenses cultured with calcium ionophore form αB-crystallin lacking the c-terminal lysine, a prominent feature of some human cataracts." Investigative Ophthalmology and Visual Science  In: , Vol. 50, No. 12, 12.2009, p. 5828-5836.
  • "Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells." Journal of Ocular Pharmacology and Therapeutics  In: , Vol. 25, No. 5, 01.10.2009, p. 409-414.
  • "The Role of Calcium-Activated Protease Calpain in Experimental Retinal Pathology." Survey of Ophthalmology  In: , Vol. 53, No. 2, 03.2008, p. 150-163.
  • "Establishment of an appropriate animal model for lacritin studies : Cloning and characterization of lacritin in monkey eyes." Experimental Eye Research  In: , Vol. 85, No. 5, 11.2007, p. 651-658.
  • "Contribution of calpain to cellular damage in human retinal pigment epithelial cells cultured with zinc chelator." Current Eye Research  In: , Vol. 32, No. 6, 06.2007, p. 565-573.
  • "Contribution of calpains to photoreceptor cell death in N-methyl-N-nitrosourea-treated rats." Experimental Neurology  In: , Vol. 204, No. 1, 03.2007, p. 39-48.
  • "PACAP Induces Neurite Outgrowth in Cultured Trigeminal Ganglion Cells and Recovery of Corneal Sensitivity After Flap Surgery in Rabbits." American Journal of Ophthalmology  In: , Vol. 143, No. 2, 02.2007.

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