Photo of Steven W. Johnson, M.D., Ph.D.

Steven W. Johnson M.D., Ph.D.

    • Professor of Neurology School of Medicine
    • Neuroscience Graduate Program School of Medicine

Dr. Johnson received his MD from University of Colorado Health Sciences University and his PhD in pharmacology from Oregon Health & Science University (OHSU). Dr. Johnson completed his neurology residency at OHSU in 1989.

Dr. Johnson joined the OHSU Movement Disorder faculty in 1990 and is now a Professor of Neurology. He maintains an active basic science program that investigates changes in brain neurochemistry that occur in animal models of Parkinson's disease. He is widely known nationally and internationally for his work that has characterized neuropharmacological actions of dopamine in the brain.

Dr. Johnson is also an expert clinician and has expertise in the clinical diagnosis and treatment of Parkinson's disease and other movement disorders.

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  • Residency:

    • Medicine, St. Lukes Presbyterian Hospital, Denver, CO
  • Fellowship:

    • Neuropharmacology-Oregon Health &Science University, Portland

Publications

  • "Phosphoinositol metabolism affects AMP kinase-dependent K-ATP currents in rat substantia nigra dopamine neurons." Brain research  In: , Vol. 1706, 01.03.2019, p. 32-40.
  • "Synaptic Plasticity Changes : Hallmark for Neurological and Psychiatric Disorders." Neural plasticity  In: , Vol. 2018, 01.01.2018.
  • "Differential actions of AMP kinase on ATP-sensitive K currents in ventral tegmental area and substantia nigra zona compacta neurons." European Journal of Neuroscience  In: , 2017.
  • "AMP kinase regulates ligand-gated K-ATP channels in substantia nigra dopamine neurons." Neuroscience  In: , Vol. 330, 25.08.2016, p. 219-228.
  • "Memantine selectively blocks extrasynaptic NMDA receptors in rat substantia nigra dopamine neurons." Brain Research  In: , Vol. 1603, 07.04.2015, p. 1-7.
  • "AMP kinase regulates K-ATP currents evoked by NMDA receptor stimulation in rat subthalamic nucleus neurons." Neuroscience  In: , Vol. 274, 22.08.2014, p. 138-152.
  • "Group i mGluRs evoke K-ATP current by intracellular Ca2+ mobilization in rat subthalamus neurons." Journal of Pharmacology and Experimental Therapeutics  In: , Vol. 345, No. 1, 04.2013, p. 139-150.
  • "Chronic dopamine depletion augments the functional expression of K-ATP channels in the rat subthalamic nucleus." Neuroscience Letters  In: , Vol. 531, No. 2, 07.12.2012, p. 104-108.
  • "Anti-dyskinetic mechanisms of amantadine and dextromethorphan in the 6-OHDA rat model of Parkinson's disease : Role of NMDA vs. 5-HT1A receptors." European Journal of Neuroscience  In: , Vol. 36, No. 9, 11.2012, p. 3224-3234.
  • "NMDA alters rotenone toxicity in rat substantia nigra zona compacta and ventral tegmental area dopamine neurons." NeuroToxicology  In: , Vol. 33, No. 3, 06.2012, p. 429-435.
  • "Regulation of polysynaptic subthalamonigral transmission by D 2, D 3 and D 4 dopamine receptors in rat brain slices." Journal of Physiology  In: , Vol. 590, No. 10, 05.2012, p. 2273-2284.
  • "Gamma-aminobutyric acidB receptor activation suppresses stimulus-evoked burst firing in rat substantia nigra reticulata neurons." NeuroReport  In: , Vol. 23, No. 1, 04.01.2012, p. 40-44.
  • "Dopamine oxidation facilitates rotenone-dependent potentiation of N-methyl-d-aspartate currents in rat substantia nigra dopamine neurons." Neuroscience  In: , Vol. 195, 10.11.2011, p. 138-144.
  • "Evaluation of the aesthetics of physical methods of euthanasia of anesthetized rats." Journal of the American Association for Laboratory Animal Science  In: , Vol. 50, No. 5, 09.2011, p. 695-701.
  • "Mitochondrial uncoupling agents antagonize rotenone actions in rat substantia nigra dopamine neurons." Brain Research  In: , Vol. 1395, 13.06.2011, p. 86-93.
  • "MK-801 inhibits l-DOPA-induced abnormal involuntary movements only at doses that worsen parkinsonism." Neuropharmacology  In: , Vol. 58, No. 7, 06.2010, p. 1002-1008.
  • "Ca2+ influx through NMDA-gated channels activates ATP-sensitive K+ currents through a nitric oxide-cGMP pathway in subthalamic neurons." Journal of Neuroscience  In: , Vol. 30, No. 5, 03.02.2010, p. 1882-1893.
  • "The sigma-1 antagonist BMY-14802 inhibits L-DOPA-induced abnormal involuntary movements by a WAY-100635-sensitive mechanism." Psychopharmacology  In: , Vol. 204, No. 4, 07.2009, p. 743-754.
  • "Erratum : The sigma-1 antagonist BMY-14802 inhibits L-DOPA-induced abnormal involuntary movements by a WAY-100635-sensitive mechanism (Psychopharmacology DOI: 10.1007/s00213-009-1505-8)." Psychopharmacology  In: , Vol. 204, No. 1, 05.2009, p. 185-187.
  • "Rotenone reduces Mg2+-dependent block of NMDA currents in substantia nigra dopamine neurons." NeuroToxicology  In: , Vol. 30, No. 2, 03.2009, p. 320-325.
  • "Rebound bursts following inhibition : How dopamine modifies firing pattern in subthalamic neurons." Journal of Physiology  In: , Vol. 586, No. 8, 15.04.2008, p. 2033.
  • "Complex EPSCs evoked in substantia nigra reticulata neurons are disrupted by repetitive stimulation of the subthalamic nucleus." Synapse  In: , Vol. 62, No. 4, 04.2008, p. 237-242.
  • "5-HT inhibits synaptic transmission in rat subthalamic nucleus neurons in vitro." Neuroscience  In: , Vol. 151, No. 4, 19.02.2008, p. 1029-1033.
  • "Sigma ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias." NeuroReport  In: , Vol. 19, No. 1, 01.2008, p. 111-115.
  • "Rotenone enhances N-methyl-D-aspartate currents by activating a tyrosine kinase in rat dopamine neurons." NeuroReport  In: , Vol. 18, No. 17, 11.2007, p. 1813-1816.
  • "Evaluation of levodopa dose and magnitude of dopamine depletion as risk factors for levodopa-induced dyskinesia in a rat model of Parkinson's disease." Journal of Pharmacology and Experimental Therapeutics  In: , Vol. 323, No. 1, 10.2007, p. 277-284.
  • "Multiple conductances are modulated by 5-HT receptor subtypes in rat subthalamic nucleus neurons." Neuroscience  In: , Vol. 148, No. 4, 21.09.2007, p. 996-1003.
  • "Rotenone potentiates NMDA currents in substantia nigra dopamine neurons." Neuroscience Letters  In: , Vol. 421, No. 2, 27.06.2007, p. 96-100.
  • "Tyramine excites rat subthalamic neurons in vitro by a dopamine-dependent mechanism." Neuropharmacology  In: , Vol. 52, No. 4, 03.2007, p. 1169-1178.
  • "Subthalamic stimulation evokes complex EPSCs in the rat substantia nigra pars reticulata in vitro." Journal of Physiology  In: , Vol. 573, No. 3, 15.06.2006, p. 697-709.

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