Photo of Shoukhrat Mitalipov, Ph.D.

Shoukhrat Mitalipov Ph.D.

    • Professor Oregon National Primate Research Center
    • Professor of Obstetrics and Gynecology School of Medicine
    • Professor and Director GT.Center for Embryonic Cell & Gene Therapy
    • Program in Molecular and Cellular Biosciences School of Medicine

Shoukhrat Mitalipov is the Director of the OHSU Center for Embryonic Cell and Gene Therapy. He is also a Professor in the Division of Reproductive & Developmental Sciences of Oregon National Primate Research Center. After receiving his Ph.D. degree, he came to Utah State University in 1995 to conduct his postdoctoral training in developmental biology. Dr. Mitalipov joined OHSU in 1998.

Areas of interest

  • Gamete and Embryo Biology
  • Mitochondrial Genetics
  • Special focus on Germline Gene Therapy

Education

  • M.S., Timiriasev Academy, Moscow Russian Federation 1987
  • Ph.D., Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow Russian Federation 1994
  • Fellowship:

    • Postdoctoral Fellow, Dept of Animal, Dairy and Veterinary Sciences, Utah State University, 1995-1998
    • Postdoctoral Fellow, Institute of Human Genetics, Muenster University, Muenster, Germany, 1995

Honors and awards

  • 2013 – Recognized by journal Nature as top 10 people who mattered in 2013
  • 2010 – Recipient of the 2010 Discovery Award, The Medical Research Foundation of Oregon
  • 2010 – Recipient of 2010 Women’s Health Research Award, the Center for Women’s Health, Circle of Giving
  • 1995 – Fellowship award, Exchange Visitor Program “Cooperation in Applied Sciences and Technologies (CAST)”. Development of culture system to maintain pluripotency of bovine embryonic stem cells. Utah State University.
  • 2017 - Recipient of “Thousand Talents Plan” Award in China in the category of the Recruitment Program for Foreign Experts

Publications

Selected publications

  • Ma H, Marti-Gutierrez N, Park SW, Wu J, Lee Y, Suzuki K, Koski A, Ji D, Hayama T, Ahmed R, Darby H, Van Dyken C, Li Y, Kang E, Park AR, Kim D, Kim ST, Gong J, Gu Y, Xu X, Battaglia D, Krieg SA, Lee DM, Wu DH, Wolf DP, Heitner SB, Belmonte JCI, Amato P, Kim JS, Kaul S, Mitalipov S. Correction of a pathogenic gene mutation in human embryos. Nature. 2017;548(7668):413-419. PMID: 28783728.

  • Kang E, Wu J, Gutierrez NM, Koski A, Tippner-Hedges R, Agaronyan K, Platero-Luengo A, Martinez-Redondo P, Ma H, Lee Y, Hayama T, Van Dyken C, Wang X, Luo S, Ahmed R, Li Y, Ji D, Kayali R, Cinnioglu C, Olson S, Jensen J, Battaglia D, Lee D, Wu D, Huang T, Wolf DP, Temiakov D, Belmonte JC, Amato P, Mitalipov S. Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. Nature. 2016;540(7632):270-275. PMID: 27919073.

  • Kang E, Wang X, Tippner-Hedges R, Ma H, Folmes CD, Gutierrez NM, Lee Y, Van Dyken C, Ahmed R, Li Y, Koski A, Hayama T, Luo S, Harding CO, Amato P, Jensen J, Battaglia D, Lee D, Wu D, Terzic A, Wolf DP, Huang T, Mitalipov S. Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs. Cell Stem Cell. 2016;18(5):625-636. PMID: 27151456.

  • Ma H, Folmes CD, Wu J, Morey R, Mora-Castilla S, Ocampo A, Ma L, Poulton J, Wang X, Ahmed R, Kang E, Lee Y, Hayama T, Li Y, Van Dyken C, Gutierrez NM, Tippner-Hedges R, Koski A, Mitalipov N, Amato P, Wolf DP, Huang T, Terzic A, Laurent LC, Izpisua Belmonte JC, Mitalipov S. Metabolic rescue in pluripotent cells from patients with mtDNA disease. Nature. 2015;524(7564):234-238. PMID: 26176921.

  • Ma H, Morey R, O'Neil RC, He Y, Daughtry B, Schultz MD, Hariharan M, Nery JR, Castanon R, Sabatini K, Thiagarajan RD, Tachibana M, Kang E, Tippner-Hedges R, Ahmed R, Gutierrez NM, Van Dyken C, Polat A, Sugawara A, Sparman M, Gokhale S, Amato P, Wolf DP, Ecker JR, Laurent LC, Mitalipov S. Abnormalities in human pluripotent cells due to reprogramming mechanisms. Nature. 2014;511(7508):177-183. PMCID: PMC4898064.

  • Kang E, Wu G, Ma H, Li Y, Tippner-Hedges R, Tachibana M, Sparman M, Wolf DP, Scholer HR, Mitalipov S. Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos. Nature. 2014;509(7498):101-104. PMCID: PMC4124901.

  • Tachibana M, Amato P, Sparman M, Gutierrez NM, Tippner-Hedges R, Ma H, Kang E, Fulati A, Lee HS, Sritanaudomchai H, Masterson K, Larson J, Eaton D, Sadler-Fredd K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer RL, Wolf D, Mitalipov S. Human embryonic stem cells derived by somatic cell nuclear transfer. Cell. 2013;153(6):1228-1238. PMCID: PMC3772789.

  • Tachibana M, Amato P, Sparman M, Woodward J, Sanchis DM, Ma H, Gutierrez NM, Tippner-Hedges R, Kang E, Lee HS, Ramsey C, Masterson K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer R, Mitalipov S. Towards germline gene therapy of inherited mitochondrial diseases. Nature. 2013;493(7434):627-631. PMCID: PMC3561483.

  • Tachibana M, Sparman M, Sritanaudomchai H, Ma H, Clepper L, Woodward J, Li Y, Ramsey C, Kolotushkina O, Mitalipov S. Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature. 2009;461(7262):367-372. PMCID: PMC2774772.

  • Kang E, Wu J, Gutierrez NM, Koski A, Tippner-Hedges R, Agaronyan K, Platero-Luengo A, Martinez-Redondo P, Ma H, Lee Y, Hayama T, Van Dyken C, Wang X, Luo S, Ahmed R, Li Y, Ji D, Kayali R, Cinnioglu C, Olson S, Jensen J, Battaglia D, Lee D, Wu D, Huang T, Wolf DP, Temiakov D, Belmonte JC, Amato P, Mitalipov S. Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. Nature. 2016;540(7632):270-275. PMID: 27919073.

Publications

  • "Discovery of a novel imprinted gene by transcriptional analysis of parthenogenetic embryonic stem cells" Human Reproduction August 2010
  • "Vliianie dlitel'nosti kul'tivirovaniia na pliuripotentnost' émbrional'nykh stvolovykh (ES) kletok myshi in vitro i in vivo." Ontogenez November 1994
  • "DNA methylation programming and reprogramming in primate embryonic stem cells" PCR Methods and Applications December 2009
  • "Towards germline gene therapy of inherited mitochondrial diseases" Nature January 31 2013
  • "Clinical and ethical implications of mitochondrial gene transfer" Trends in Endocrinology and Metabolism January 2014
  • "Producing primate embryonic stem cells by somatic cell nuclear transfer" Nature November 21 2007
  • "Cell cycle features of primate embryonic stem cells" Stem Cells March 2006
  • "Erratum" Stem Cells March 2006
  • "Methylation status of imprinting centers for H19/IGF2 and SNURF/SNRPN in primate embryonic stem cells" Stem Cells March 2007
  • "Development of nuclear transfer and parthenogenetic rabbit embryos activated with inositol 1,4,5-trisphosphate" Biology of Reproduction  1999
  • "Nuclear transfer in nonhuman primates." Methods in molecular biology (Clifton, N.J.)  2006
  • "Developmental biology" Nature May 28 2009
  • "Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells" Stem Cells February 2007
  • "Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy" Proceedings of the National Academy of Sciences of the United States of America December 24 2013
  • "Pluripotent stem cells" Ontogenez November 2008
  • "Genomic imprinting in primate embryos and embryonic stem cells" Reproduction, Fertility and Development  2006
  • "Totipotency, pluripotency and nuclear reprogramming"   2009
  • "Mammalian cloning" Annals of Medicine  2000
  • "Cloning Primates"  October 2013
  • "Chromosome transfer in mature oocytes." Fertility and Sterility May 2012
  • "Differentiation of monkey embryonic stem cells into neural lineages" Biology of Reproduction May 1 2003
  • "Reprogramming following somatic cell nuclear transfer in primates is dependent upon nuclear remodeling" Human Reproduction August 2007
  • "Aberrant genomic imprinting in rhesus monkey embryonic stem cells" Stem Cells March 2006
  • "A comparative approach to somatic cell nuclear transfer in the rhesus monkey" Human Reproduction October 2006
  • "Erratum" Nature December 11 2014
  • "Generation of chimeric rhesus monkeys" Cell January 20 2012
  • "Isolation and characterization of novel rhesus monkey embryonic stem cell lines" Stem Cells October 2006
  • "Developmental competence of oocytes after ICSI in the rhesus monkey" Human Reproduction  2001
  • "Abnormalities in human pluripotent cells due to reprogramming mechanisms" Nature  2014
  • "Rapid Mitochondrial DNA Segregation in Primate Preimplantation Embryos Precedes Somatic and Germline Bottleneck" Cell Reports May 31 2012

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