Photo of Sara A Courtneidge, Ph.D., D.Sc.

Sara A Courtneidge Ph.D., D.Sc.

  • (503) 496-4750
    • Professor of Cell, Developmental and Cancer Biology School of Medicine
    • Cell and Developmental Biology Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Sara A. Courtneidge was born in the UK, and received her B.Sc. from the University of Leeds and her Ph.D. from the National Institute for Medical Research, London. Following postdoctoral study at the University of California, San Francisco, and an independent position at the National Institute for Medical Research, she joined the European Molecular Biology Laboratory in Heidelberg, Germany in 1985, where she rose to the position of Senior Scientist. Changing course in 1994, Dr. Courtneidge joined SUGEN Inc., where as Chief Scientist she guided novel kinase discovery and validation efforts in oncology. From 2001-2005 she was Distinguished Scientific Investigator at the Van Andel Research Institute in Grand Rapids, Michigan, and from 2005-2014 she served as Professor and Director of the Tumor Microenvironment and Metastasis Program, and Director of Academic Affairs, at the Sanford|Burnham Medical Research Institute. She joined OHSU in 2014, where she is an Associate Director of Translational Sciences for the Knight Cancer Institute, a Professor in the Department of Cell, Developmental & Cancer Biology, and a member of the Center for Spatial Systems Biomedicine. Dr. Courtneidge’s laboratory has studied the Src family of protein tyrosine kinases for a number of years, and has contributed to the understanding of Src transformation, regulation, substrate selection and function. Currently, her research on Src and it substrates focuses on cancer invasion and metastasis, with particular emphasis on the role of membrane structures called podosomes or invadopodia. She also retains an interest in translational research, with the goal of defining novel therapeutic points of intervention for cancer treatment. Dr. Courtneidge’s contributions to cancer research have been recognized with numerous honors, including election to the European Molecular Biology Organization, the Jubilee Lecture and Harden Medal of the British Biochemical Society, the Feodor Lynen Lecture and Lynen Medal, an honorary doctorate from the University of Leeds, and, most recently, the 2015 AACR-WICR Charlotte Friend Memorial Lectureship.

Publications

  • "Cell regulation. Editorial overview" Current Opinion in Cell Biology  1996
  • "Further characterisation of the complex containing middle T antigen and pp60." Current Topics in Microbiology and Immunology  1989
  • "The ADAMs family of metalloproteases" Genes and Development January 1 2003
  • "The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells" Cancer Cell February 2005
  • "Cancer" Nature April 24 2003
  • "Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis" Cell Reports  2014
  • "Genetic and cellular mechanisms of oncogenesis" Current Opinion in Genetics and Development February 2007
  • "Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis" Proceedings of the National Academy of Sciences of the United States of America June 19 2001
  • "Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases." Molecular Cancer Research October 1991
  • "Src regulated by C-terminal phosphorylation is monomeric" Proceedings of the National Academy of Sciences of the United States of America April 15 1997
  • "Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling" Molecular Cell January 2000
  • "Identification and Characterization of the Hamster Polyomavirus Middle T Antigen" Journal of Virology June 1991
  • "Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src" Nature  1995
  • "PI 3-kinase is a dual specificity enzyme" EMBO Journal February 1 1994
  • "Endothelial cell transformation by polyomavirus middle T antigen in mice lacking Src-related kinases" Current Biology February 1 1994
  • "Association of Fyn with the activated platelet-derived growth factor receptor" Oncogene October 1992
  • "The crystal structure of human CskSH3" FEBS Letters March 14 1994
  • "The invadopodia scaffold protein Tks5 is required for the growth of human breast cancer cells in vitro and in vivo" PLoS One March 31 2015
  • "Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns" Biochemical Journal  1992
  • "The Src SH3 domain is required for DNA synthesis induced by platelet- derived growth factor and epidermal growth factor" Journal of Biological Chemistry  1996
  • "Induction of interleukin-2 transcription by the hamster polyomavirus middle T antigen" European Journal of Immunology February 1995
  • "The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1" Molecular Biology of the Cell July 2008
  • "Fibroblast growth factor receptor-1 regulation of Src family kinases" Oncogene  1995
  • "No requirement for Src family kinases for PDGF signaling in fibroblasts expressing SV40 large T antigen" Oncogene June 1 2000
  • "Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors" Journal of Biological Chemistry  1995
  • "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells" Journal of Biological Chemistry May 9 2003
  • "Rapid and efficient purification of Src homology 2 domain-containing proteins" Biochemical Journal  1994
  • "MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro" Journal of Cell Biology April 5 2010
  • "Cytotoxic T cells to type A influenza virus; viral hemagglutinin induces A-strain specificity while infected cells confer cross-reactive cytotoxicity" European Journal of Immunology  1977
  • "The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice" Cell Death and Differentiation  2009

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