Photo of Robert F. Klein, M.D.

Robert F. Klein M.D.

    • Professor of Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition School of Medicine
    • Graduate Programs in Human Nutrition School of Medicine

Dr. Klein received his medical degree in 1980 from the University of California-San Francisco. He completed his residency at New York Hospital-Columbia University Medical Center, and underwent his fellowship in diabetes, endocrinology and metabolism at UCSF. Dr. Klein became board certified in internal medicine in 1983, and in endocrinology in 1987.

  • Residency:

    • New York Hospital, Columbia University Medical Center
  • Fellowship:

    • Diabetes/endocrinology/metabolism-University of California, San Francisco

Memberships and associations

  • Internal medicine, 1983


  • "Regulation of lean mass, bone mass, and exercise tolerance by the central melanocortin system" PLoS One July 27 2012
  • "Adrenocortical function in acquired immunodeficiency syndrome" Journal of Clinical Endocrinology and Metabolism  1987
  • "Parathyroid hormone-like adenylate cyclase-stimulating activity from a human carcinoma is associated with bone-resorbing activity" Endocrinology  1987
  • "Genetic regulation of bone mineral density in mice" Journal of Musculoskeletal Neuronal Interactions  2002
  • "Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar collagen-rich tissues such as tendons, skin, and bones (The Journal of Biological Chemistry (2010) 285, (17253-17262) DOI" Journal of Biological Chemistry June 25 2010
  • "Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones" Journal of Pharmacology and Experimental Therapeutics  1991
  • "Neonatal estrogen exposure results in biphasic age-dependent effects on the skeletal development of male mice" Endocrinology January 1 2015
  • "Sex and the single nucleotide polymorphism" Journal of Bone and Mineral Research October 2012
  • "A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia" Proceedings of the National Academy of Sciences of the United States of America August 18 2009
  • "Forskolin mimics the effects of calcitonin but not parathyroid hormone on bone resorption in vitro" Bone and Mineral  1988
  • "Melanocortin-3 receptor regulates the normal fasting response" Proceedings of the National Academy of Sciences of the United States of America June 5 2012
  • "Perioperative parathyroid hormone levels in thyroid surgery" Laryngoscope April 2006
  • "Increased serum levels of a parathyroid hormone-like protein in malignancy-associated hypercalcemia" Annals of Internal Medicine  1989
  • "The Genetics of Peak Bone Mass"   2010
  • "A trial of amitriptyline and fluphenazine in the treatment of painful diabetic neuropathy" JAMA - Journal of the American Medical Association  1986
  • "The bone disease associated with factor VIII deficiency in mice is secondary to increased bone resorption" Haemophilia November 2013
  • "The transiliac bone biopsy" Endocrinologist  1992
  • "Vitamin D metabolites and bioactive parathyroid hormone levels during Spacelab 2" Aerospace medicine and human performance  1988
  • "Congenic mice provide in vivo evidence for a genetic locus that modulates intrinsic transforming growth factor β1-mediated signaling and bone acquisition" Journal of Bone and Mineral Research June 2012
  • "Bone loss in men" Endocrinologist  1994
  • "A Trial of Amitriptyline and Fluphenazine in the Treatment of Painful Diabetic Neuropathy" JAMA - Journal of the American Medical Association February 7 1986
  • "High performance liquid chromatography used to distinguish the autoimmune hypoglycemia syndrome from factitious hypoglycemia" Journal of Clinical Endocrinology and Metabolism  1985
  • "In silico mapping of complex disease-related traits in mice" Science June 8 2001
  • "Phenotypic characterization of mice bred for high and low peak bone mass" Journal of Bone and Mineral Research  2001
  • "Osteoporosis in men" Endocrine Reviews  1995
  • "Genetics of osteoporosis - Utility of mouse models" Journal of Musculoskeletal Neuronal Interactions  2008
  • "Nonpharmacological approaches to improve bone health and reduce osteoporosis" Current Opinion in Rheumatology March 2008
  • "Ethanol inhibits human osteoblastic cell proliferation" Alcoholism: Clinical and Experimental Research  1996
  • "Relationship of muscle capillary basement membrane thickness and diabetic retinopathy" Diabetes Care  1987
  • "Murine models of osteoporosis"   2005

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