Photo of Robb E. Moses, M.D.

Robb E. Moses M.D.

    • Professor Emeritus of Molecular and Medical Genetics School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine

My lab studies DNA crosslink repair using two model systems. Fanconi anemia is a recessive disease affecting multiple organ systems and results in severe anemia and an increased risk of leukemia. Cells from the patients are hypersensitive to DNA crosslinkers. The Moses group is part of a program project on Fanconi anemia and has participated in the positional cloning of one of the genes, from among at least twelve. The role of the FA genes inrepair of DNA cross links is intriguing not just because of the association with disease, but because the FA cells are competent in all other types of DNA repair tested. Our current work is focused on the role of chromatin remodeling in FA and potential defects in remodeling which might affect ICL repair. A second project investigates the function a mammalian gene responsible for crosslink repair, the hSNM1 gene. We have isolated the protein encoded by the gene and it is a 5’-exonuclease which is required for intermediate processing in the repair of ICLs.

Education

  • M.D., Johns Hopkins University Medical School 1966
  • Residency:

    • Johns Hopkins Hospital, Baltimore
  • Fellowship:

    • Fellowship in biochemistry, Harvard Medical School, Boston

Memberships and associations

  • Medical genetics, 1982

Publications

  • "Holoenzyme DNA polymerase III fixes mutations" Mutation Research Letters  1990
  • "The Ashkenazi Jewish fanconi anemia mutations" Human Mutation  1994
  • "DNA interstrand crosslink repair in mammalian cells" Journal of Cellular Physiology September 2009
  • "A FANCD2 domain activates Tip60-dependent apoptosis" Cell Biology International September 2010
  • "Map location of the pcbA mutation and physiology of the mutant" Journal of Bacteriology  1984
  • "Excision of pyrimidine dimers in toluene treated Escherichia coli" Journal of Bacteriology  1976
  • "Diseases with DNA damage-processing defects." American Journal of the Medical Sciences January 1988
  • "Partial purification on an endonuclease that cleaves bleomycin treated DNA" Federation Proceedings  1981
  • "BRCA1 interacts directly with the Fanconi anemia protein FANCA" Human Molecular Genetics October 1 2002
  • "Enzymatic mechanisms of DNA replication in Escherichia coli." Federation Proceedings September 1972
  • "The yeast Snm1 protein is a DNA 5′-exonuclease" DNA Repair February 3 2005
  • "REGγ deficiency promotes premature aging via the casein kinase 1 pathway" Proceedings of the National Academy of Sciences of the United States of America July 2 2013
  • "uvrC gene function in excision repair in toluene-treated Escherichia coli" Journal of Bacteriology  1979
  • "Fanconi anemia group A and D cell lines respond normally to inhibitors of cell cycle regulation" Somatic Cell and Molecular Genetics  1998
  • "Topo IIIα and BLM act within the fanconi anemia pathway in response to DNA-crosslinking agents" Cytogenetic and Genome Research September 2009
  • "Multiple pathways for repair of hydrogen peroxide-induced DNA damage in Escherichia coli." Journal of Bacteriology February 1989
  • "Repair of bleomycin-damaged DNA by human fibroblasts"   1981
  • "Distal regulatory functions for the uvrC of E. coli" Nucleic Acids Research July 11 1984
  • "Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells" Mutation Research - DNA Repair  1990
  • "Denervation effects on newt limb regeneration" Developmental Biology  1973
  • "Inactivation of the 5′-3′ exonuclease of Thermus aquaticus DNA polymerase" Biochimica et Biophysica Acta - Gene Structure and Expression November 7 1995
  • "Effect of bleomycin on deoxyribonucleic acid synthesis in toluene treated Escherichia coli cells" Antimicrobial Agents and Chemotherapy  1976
  • "Ultraviolet irradiation induced DNA synthesis in toluene treated Escherichia coli cells" Federation Proceedings  1974
  • "Permeabilized cells" ImmunoMethods  1995
  • "Conversion of replicative intermediates in human DNA-repair defective cells" Experimental Cell Research  1986
  • "Repair response to bleomycin-induced damage"   1978
  • "Nonspecific cleavage of φX174 RFI deoxyribonucleic acid by bleomycin" Biochemistry  1981
  • "Intermolecular plasmid recombination in fibroblasts from humans with DNA damage-processing defects" Plasmid  1989
  • "Repair of bleomycin-damaged DNA by human fibroblasts"   1981
  • "The hSNM1 protein is a DNA 5′-exonuclease" Nucleic Acids Research September 2007

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