Photo of Randy L. Woltjer, M.D., Ph.D.

Randy L. Woltjer M.D., Ph.D.

  •      (503) 494-0100
    • Associate Professor of Pathology School of Medicine
    • Director, Neuropathology Core of the Layton Aging & Alzheimer’s Disease Center

Education

  • B.S., Grand Rapids, Grand Rapids Michigan 1985
  • M.A., Michigan State University, East Lansing Michigan 1986
  • Ph.D., Vanderbilt University, Nashville Tennessee 1992
  • M.D., Vanderbilt University, Nashville Tennessee 1994
  • Residency:

    • Pathology, Vanderbilt University Medical Center, 1994-1997
  • Fellowship:

    • Research and Clinical Pathology, Vanderbuilt University Medical Center, Nashville Tennessee, 1997-2000
    • Neuropathology, Vanderbilt University Medical Center, Nashville, Tennessee, 2000-2002
    • Fellow, OHSU Human Investigations Program, Portland, Oregon, 2008-2009
  • Certifications:

    • Anatomic and Clinical Pathology, American Board of Pathology, 2000
    • Neuropathology, American Board of Pathology, 2005

Memberships and associations

  • Society for Free Radical Biology and Medicine American Society for Investigative Pathology

Publications

  • "Genes and pathways underlying regional and cell type changes in Alzheimer's disease" Genome Medicine May 25 2013
  • "Novel histopathologic findings in molecularly-confirmed pantothenate kinase-associated neurodegeneration" Brain April 2011
  • "Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+in cognitively intact aged individuals with Alzheimer's disease neuropathology" Molecular Neurodegeneration May 28 2012
  • "Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions" Nature Genetics March 2010
  • "Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML" Blood September 27 2012
  • "F 2-Dihomo-isoprostanes arise from free radical attack on adrenic acid" Journal of Lipid Research May 1 2008
  • "Liquid Chromatography with Tandem Mass Spectrometry-Based Proteomic Discovery in Aging and Alzheimer's Disease" Neurotherapeutics July 2006
  • "Trajectory of white matter hyperintensity burden preceding mild cognitive impairment" Neurology August 21 2012
  • "Nephrogenic systemic fibrosis presenting as myopathy" Neuromuscular Disorders June 2010
  • "Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases" Acta Neuropathologica September 2007
  • "Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis" Nature Genetics December 2012
  • "Quantitation and mapping of cerebral detergent-insoluble proteins in the elderly" Brain Pathology July 2009
  • "Aggressive course in encephalitis with opsoclonus, ataxia, chorea, and seizures the first pediatric case of y-aminobutyric acid type B receptor autoimmunity" JAMA Neurology  2014
  • "Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration" Archives of Neurology April 2011
  • "Alzheimer disease pathology in cognitively healthy elderly" Neurobiology of Aging December 2011
  • "Neuropathologic basis of age-associated brain atrophy" JAMA Neurology  2013
  • "Mutations in gamma adducin are associated with inherited cerebral palsy" Annals of Neurology December 2013
  • "Correlation of alzheimer disease neuropathologic changes with cognitive status" American Journal of Psychotherapy May 2012
  • "Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient" Brain Pathology April 2008
  • "Dysregulated phosphorylation of Ca 2+/calmodulin-dependent protein kinase II-α in the hippocampus of subjects with mild cognitive impairment and Alzheimer's disease" Journal of Neurochemistry November 2011
  • "Advanced glycation endproduct precursor alters intracellular amyloid- β/AβPP carboxy-terminal fragment aggregation and cytotoxicity" Journal of Alzheimer's Disease December 2003
  • "Neuropathologic effects of chemical warfare agents"   2009
  • "Role of soluble epoxide hydrolase in age-related vascular cognitive decline" Prostaglandins and Other Lipid Mediators September 30 2014
  • "Amyloid-β1-42 slows clearance of synaptically released glutamate by mislocalizing astrocytic GLT-1" Journal of Neuroscience March 20 2013
  • "Effects of sulfhydryl modification reagents on the kinase activity of the epidermal growth factor receptor" Biochemistry August 12 1997
  • "Quantitative proteomics identifies surfactant-resistant α-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy" American Journal of Pathology September 2007
  • "Alzheimer's disease and non-demented high pathology control nonagenarians" PLoS One November 7 2011
  • "Manipulation of microglial activation as a therapeutic strategy in Alzheimer's disease" Current Medicinal Chemistry November 2007
  • "NMDA receptor encephalitis mimicking seronegative neuromyelitis optica" Neurology May 2010
  • "Pathologic quiz case" Archives of Pathology and Laboratory Medicine  2003

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