Photo of Pierre T. Moenne-Loccoz, Ph.D.

Pierre T. Moenne-Loccoz Ph.D.

    • Associate Professor EH.Environmental & Biomolecular Systems

University of Oregon, Postdoctoral Research Associate, Department of Chemistry, 1990-92

University College London, Department of Biology, 1992-93

OHSU/OGI School of Science & Engineering, 1994-95; Research Scientist, 1996-1999; Research Assistant Professor, 1999-2000; Assistant Professor, 2000-2007

Research interests: Structure-function relationships within proteins. Metalloenzymes and hemoproteins. Spectroscopic studies of enzymatic active sites, cofactors, and metal clusters. Reaction intermediates within catalysis. Nitric oxide in bioinorganic chemistry.

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Publications

  • "Rational reprogramming of the R2 subunit of Escherichia coli ribonucleotide reductase into a self-hydroxylating monooxygenase" Journal of the American Chemical Society  2001
  • "Heme oxidation in a chimeric protein of the α-selective Neisseriae meningitidis heme oxygenase with the distal helix of the δ-selective Pseudomonas aeruginosa" Biochemistry October 25 2005
  • "Heme oxygenase-1, intermediates in verdoheme formation and the requirement for reduction equivalents" Journal of Biological Chemistry March 14 1997
  • "Electrostatic environment of the tryptophylquinone cofactor in methylamine dehydrogenase" Biochemistry April 16 1996
  • "Opposite movement of the external gate of a glutamate transporter homolog upon binding cotransported sodium compared with substrate" Journal of Neuroscience April 20 2011
  • "Vibrational analysis of mononitrosyl complexes in hemerythrin and flavodiiron proteins" Journal of the American Chemical Society April 18 2012
  • "A low-spin alkylperoxo-iron(III) complex with weak Fe-O and O-O bonds" Journal of the American Chemical Society November 8 2006
  • "Structural, NMR spectroscopic, and computational investigation of hemin loading in the hemophore hasap from pseudomonas aeruginosa" Journal of the American Chemical Society July 21 2010
  • "O2 activation by non-heme diiron proteins" Biochemistry October 20 1998
  • "Interdomain interactions within the two-component heme-based sensor DevS from Mycobacterium tuberculosis" Biochemistry August 28 2007
  • "Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 2. Effects on heme coordination and function" Biochemistry February 6 2001
  • "Nitric oxide dioxygenation reaction in devS and the initial response to nitric oxide in mycobacterium tuberculosis" Biochemistry February 15 2011
  • "Heme/Cu/O2 reactivity" Journal of the American Chemical Society October 13 2004
  • "Characterizing millisecond intermediates in hemoproteins using rapid-freeze-quench resonance Raman spectroscopy" Methods in molecular biology (Clifton, N.J.)  2014
  • "The millisecond intermediate in the reaction of nitric oxide with oxymyoglobin is an iron(III)-nitrato complex, not a peroxynitrite" Journal of the American Chemical Society June 3 2009
  • "Path of electron transfer in photosystem 1" Biochemistry  1994
  • "Fourier transform infrared characterization of the azido complex of methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath)" Journal of the American Chemical Society March 30 2005
  • "Reactivity studies on FeIII-(O2 2-)-Cu II compounds" Inorganic Chemistry August 6 2007
  • "Dioxygen and nitric oxide reactivity of a reduced heme/non-heme diiron(II) complex [(5L)Fe(II)···Fe(II)-Cl]+. Using a tethered tetraarylporphyrin for the development of an active site reactivity model for bacterial nitric oxide reductase" Inorganica Chimica Acta  2000
  • "Nitric oxide in biological denitrification" Chemical Reviews April 2002
  • "Proximal ligand electron donation and reactivity of the cytochrome P450 ferric-peroxo anion" Journal of the American Chemical Society April 18 2012
  • "Coupled oxidation vs heme oxygenation" Journal of the American Chemical Society April 9 2003
  • "Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae" Protein Expression and Purification April 1 2003
  • "Carboxylate as the protonation site in (peroxo)diiron(III) model complexes of soluble methane monooxygenase and related diiron proteins" Journal of the American Chemical Society February 3 2010
  • "Purification and characterization of the MQH2" Journal of Biological Chemistry September 19 2003
  • "Spectroscopic characterization of heme iron-nitrosyl species and their role in NO reductase mechanisms in diiron proteins" Natural Product Reports  2007
  • "Structural characterization of the catalytic high-spin heme b of nitric oxide reductase" Journal of the American Chemical Society June 3 1998
  • "Formation and characterization of a high-spin heme-copper dioxygen (peroxo) complex [8]" Journal of the American Chemical Society October 27 1999
  • "Accessibility of the distal heme face, rather than Fe-His bond strength, determines the heme-nitrosyl coordination number of cytochromes c′" Biochemistry June 21 2005
  • "Biochemistry" Science December 17 2010

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