Photo of Penelope Hogarth, M.D.

Penelope Hogarth M.D.

Director of clinical research: Dr. Penny Hogarth joined the OHSU movement disorders faculty in 2000 and is currently an associate professor of neurology. She holds a joint appointment as clinician scientist at the VA Medical Center and a joint appointment in the department of genetics. Dr. Hogarth’s research interests have focused on deep brain stimulation for Parkinson's disease and the natural history of Huntington’s disease. She heads up the DBS cooperative study comparing best medical management versus stimulation of subthalamic nucleus and globus pallidus for the treatment of Parkinson's disease. She is also part of the Huntington’s study group and is interested in novel therapies for Huntington’s disease. Dr. Hogarth is an expert clinician in all movement disorders with a special interest in Huntington’s disease.

  • Residency:

    • University of Colorado School of Medicine, Denver
  • Fellowship:

    • Experimental therapeutics and movement disorders, University of Rochester, Rochester, N.Y., 2000.

Memberships and associations

  • Neurology, 1999

Publications

  • "Novel histopathologic findings in molecularly-confirmed pantothenate kinase-associated neurodegeneration" Brain April 2011
  • "Neuro-ophthalmologic and electroretinographic findings in pantothenate kinase-associated neurodegeneration (formerly Hallervorden-Spatz syndrome)" American Journal of Ophthalmology August 2005
  • "The national DBS brain tissue network pilot study" Cell and Tissue Banking August 2011
  • "The effect of deep brain stimulation randomized by site on balance in Parkinson's disease" Movement Disorders  2014
  • "Neurodegeneration associated with genetic defects in phospholipase A2" Neurology October 28 2008
  • "Randomized trial of deep brain stimulation for Parkinson disease" Neurology July 3 2012
  • "Clinical features of neurodegeneration with brain iron accumulation due to a C19orf12 gene mutation" Movement Disorders September 2013
  • "Multisite randomized trial of deep brain stimulation [4] (multiple letters)" Archives of Neurology October 2005
  • "Neuropsychological changes following deep brain stimulation surgery for Parkinson's disease" Journal of Neurology, Neurosurgery and Psychiatry June 1 2015
  • "Bilateral deep brain stimulation vs best medical therapy for patients with advanced parkinson disease" JAMA - Journal of the American Medical Association January 7 2009
  • "Effects of deep brain stimulation in the subthalamic nucleus or globus pallidus internus on step initiation in Parkinson disease" Journal of Neurosurgery December 2012
  • "Pallidal vs subthalamic nucleus deep brain stimulation in Parkinson disease" Archives of Neurology April 2005
  • "Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease" Movement Disorders June 1 2015
  • "Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset" Proceedings of the National Academy of Sciences of the United States of America March 9 2004
  • "Treatment of ADHD in children with tics" Neurology February 26 2002
  • "Exome sequencing reveals de novo WDR45 mutations causing a phenotypically distinct, X-linked dominant form of NBIA" American Journal of Human Genetics December 7 2012
  • "Parkinson's disease" Current Neurology and Neuroscience Reports July 2001
  • "Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease" Proceedings of the National Academy of Sciences of the United States of America August 2 2005
  • "The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset" Annals of Human Genetics May 2007
  • "Correlates of excessive daytime sleepiness in de novo Parkinson's disease" Movement Disorders September 1 2015
  • "BPAN. The Only X-Linked Dominant NBIA Disorder" International Review of Neurobiology  2013
  • "Domains and correlates of clinical balance impairment associated with Huntington's disease" Gait and Posture March 1 2015
  • "Effects of a NR2B selective NMDA glutamate antagonist, CP-101,606, on dyskinesia and parkinsonism" Movement Disorders October 15 2008
  • "Intellectual and adaptive behaviour functioning in pantothenate kinase-associated neurodegeneration" Journal of Intellectual Disability Research June 2007
  • "A dissociation between symbolic number knowledge and analogue magnitude information" Brain and Cognition  2001
  • "Huntington disease" Neurology May 28 2013
  • "Interrater agreement in the assessment of motor manifestations of Huntington's disease" Movement Disorders March 2005
  • "Metabolism and energy requirements in pantothenate kinase-associated neurodegeneration" Molecular Genetics and Metabolism November 2013
  • "Site of deep brain stimulation and jaw velocity in Parkinson disease" Journal of Neurosurgery November 2011
  • "Sodium phenylbutyrate in Huntington's disease" Movement Disorders October 15 2007

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