Photo of Paul Brehm, Ph.D.

Paul Brehm Ph.D.

Paul Brehm received his degree in zoology from the University of Wisconsin before entering the PhD program at UCLA where he trained with James Morin in marine biology and bioluminescence. Postgraduate training with Roger Eckert at UCLA and Yoshi Kidokoro at The Salk Institute focused on calcium channels and synaptic transmission. The next 10 years were spent as an associate professor in the Department of Physiology at Tufts Medical School in Boston and summers at the Marine Biological Laboratory at Woods Hole. In 1990 Brehm moved to Stony Brook University in New York where he served as professor of Neurobiology and Behavior before assuming a position as senior scientist at the Vollum in 2007.

Dr. Brehm's lab is currently focused on several projects involving ion channels and synaptic transmission in vertebrate animal models.

Areas of interest

  • zebrafish genetics
  • electrophysiology
  • ion channel function
  • imaging

Education

  • B.S., University of Wisconsin, Madison 1970
  • Ph.D., University of California, Los Angeles 1975

Honors and awards

  • AAAS Fellow
  • Jacob J. Javits Neuroscience Investigator, NIH, NINDS
  • Eureka Awardee, NIH, NINDS
  • McKnight Technology Awardee
  • Muscular Dystrophy Association Fellow
  • NIH Director's Award

Publications

  • "Astrocytic modulation of excitatory synaptic signaling in a mouse model of Rett syndrome." eLife  In: , Vol. 7, e31629, 09.01.2018.
  • "A Gradient in Synaptic Strength and Plasticity among Motoneurons Provides a Peripheral Mechanism for Locomotor Control." Current Biology  In: , Vol. 27, No. 3, 06.02.2017, p. 415-422.
  • "Fatigue in rapsyn-deficient zebrafish reflects defective transmitter release." Journal of Neuroscience  In: , Vol. 36, No. 42, 19.10.2016, p. 10870-10882.
  • "Nonequivalent release sites govern synaptic depression." Proceedings of the National Academy of Sciences of the United States of America  In: , Vol. 113, No. 3, 19.01.2016, p. E378-E386.
  • "Zebrafish Ca2.1 Calcium Channels Are Tailored for Fast Synchronous Neuromuscular Transmission." Biophysical Journal  In: , Vol. 108, No. 3, 03.02.2015, p. 578-584.
  • "Synchronous and asynchronous modes of synaptic transmission utilize different calcium sources." eLife  In: , Vol. 2013, No. 2, e01206, 24.12.2013.
  • "Zebrafish calls for reinterpretation for the roles of P/Q calcium channels in neuromuscular transmission." Journal of Neuroscience  In: , Vol. 33, No. 17, 24.04.2013, p. 7384-7392.
  • "Zebrafish model for congenital myasthenic syndrome reveals mechanisms causal to developmental recovery." Proceedings of the National Academy of Sciences of the United States of America  In: , Vol. 109, No. 43, 23.10.2012, p. 17711-17716.
  • "Acetylcholine receptor gating in a zebrafish model for slow-channel syndrome." Journal of Neuroscience  In: , Vol. 32, No. 23, 06.06.2012, p. 7941-7948.
  • "An acetylcholine receptor lacking both γ and ε subunits mediates transmission in zebrafish slow muscle synapses." Journal of General Physiology  In: , Vol. 138, No. 3, 09.2011, p. 353-366.
  • "Paired patch clamp recordings from motor-neuron and target skeletal muscle in zebrafish." Journal of Visualized Experiments  In: , No. 45, e2351, 11.2010.
  • "Distinct roles for two synaptotagmin isoforms in synchronous and asynchronous transmitter release at zebrafish neuromuscular junction." Proceedings of the National Academy of Sciences of the United States of America  In: , Vol. 107, No. 31, 03.08.2010, p. 13906-13911.
  • "Synaptic homeostasis in a zebrafish glial glycine transporter mutant." Journal of Neurophysiology  In: , Vol. 100, No. 4, 10.2008, p. 1716-1723.
  • "Function of neuromuscular synapses in the zebrafish choline- acetyltransferase mutant bajan." Journal of Neurophysiology  In: , Vol. 100, No. 4, 10.2008, p. 1995-2004.
  • "An electrically coupled network of skeletal muscle in zebrafish distributes synaptic current." Journal of General Physiology  In: , Vol. 128, No. 1, 2006, p. 89-102.
  • "Paired motor neuron-muscle recordings in zebrafish test the receptor blockade model for shaping synaptic current." Journal of Neuroscience  In: , Vol. 25, No. 35, 31.08.2005, p. 8104-8111.
  • "A mutation in serca underlies motility dysfunction in accordion zebrafish." Developmental Biology  In: , Vol. 276, No. 2, 15.12.2004, p. 441-451.
  • "Persistent electrical coupling and locomotory dysfunction in the zebrafish mutant shocked." Journal of Neurophysiology  In: , Vol. 92, No. 4, 10.2004, p. 2003-2009.
  • "Tethering naturally occurring peptide toxins for cell-autonomous modulation of ion channels and receptors in vivo." Neuron  In: , Vol. 43, No. 3, 05.08.2004, p. 305-311.
  • "Acetylcholine receptors direct rapsyn clusters to the neuromuscular synapse in zebrafish." Journal of Neuroscience  In: , Vol. 24, No. 24, 16.06.2004, p. 5475-5481.
  • "Increased neuromuscular activity causes axonal defects and muscular degeneration." Development  In: , Vol. 131, No. 11, 06.2004, p. 2605-2618.
  • "Optical Measurements of Presynaptic Release in Mutant Zebrafish Lacking Postsynaptic Receptors." Journal of Neuroscience  In: , Vol. 23, No. 33, 19.11.2003, p. 10467-10474.
  • "The zebrafish motility mutant twitch once reveals new roles for rapsyn in synaptic function." Journal of Neuroscience  In: , Vol. 22, No. 15, 01.08.2002, p. 6491-6498.
  • "Regulation of neuronal traits by a novel transcriptional complex." Neuron  In: , Vol. 31, No. 3, 16.08.2001, p. 353-365.
  • "Paralytic zebrafish lacking acetylcholine receptors fail to localize rapsyn clusters to the synapse." Journal of Neuroscience  In: , Vol. 21, No. 15, 01.08.2001, p. 5439-5448.
  • "Calcium channel isoforms underlying synaptic transmission at embryonic Xenopus neuromuscular junctions." Journal of Neuroscience  In: , Vol. 21, No. 2, 15.01.2001, p. 412-422.
  • "Progesterone treatment abolishes exogenously expressed ionic currents in Xenopus oocytes." American Journal of Physiology - Cell Physiology  In: , Vol. 280, No. 3 49-3, 2001.
  • "Calcium channels in Xenopus spinal neurons differ in somas and presynaptic terminals." Journal of Neurophysiology  In: , Vol. 86, No. 1, 2001, p. 269-279.
  • "Distinction among neuronal subtypes of voltage-activated sodium channels by μ-conotoxin PIIIA." Journal of Neuroscience  In: , Vol. 20, No. 1, 01.01.2000, p. 76-80.
  • "Voltage-dependent sodium channel function is regulated through membrane mechanics." Biophysical Journal  In: , Vol. 77, No. 4, 10.1999, p. 1945-1959.

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