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Oscar Miranda-Dominguez

Oscar is a biomedical engineer with more than nine years of experience in research, industry and academy. He holds a Master’s Degree in Control Engineering and Automation (Tecnologico de Monterrey), and a PhD from the department of Biomedical Engineering at the University of Minnesota. He is currently a Research Assistant Professor in the Department of Behavioral Neuroscience in Oregon Health and Science University (OHSU) where he has developed expertise in neuroimaging and clinical research.

He has studied the brain at different spatiotemporal scales by using different mathematical frameworks and experimental approaches, going from single cell recordings in the hippocampal formation in rats to non-invasive functional MRI in mice, macaques and humans.

He has directed his training to developed methods and technologies combining the latest findings from neuroimaging, electrophysiology, and clinical psychology to identify biomarkers of psychiatric and neurological disorders at their earlier manifestations, and to build model-based approaches to therapeutics. To this end, he is using functional MRI to a) extract unique and stable personalized brain fingerprints in different species that can be detected with limited data, b) identify shared patterns of brain connectivity among groups that generalize across studies, and c) methods to bridge functional neuroimaging findings across species.

As a member of the Developmental Cognition and Neuroimaging (DCAN) laboratory he collaborates closely with the Parkinson’s Center of Oregon in several Projects aimed to characterize how brain function relates to cognition and mobility.

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Areas of interest

  • Neuroimaging
  • Neuromodulation
  • Mathematical modeling of physiological systems
  • Computational neuroscience
  • Data assimilation and signal processing
  • Design of medical devices
  • Closed loop control

Education

  • B.S., Instituto Politecnico Nacional, Mexico City, Mexico 2000
  • M.S., Tecnologico de Monterrey, Monterrey, Nuevo Leon, Mexico 2001
  • Ph.D., University of Minnesota, Minneapolis Minnesota United States 2012
  • Fellowship:

    • Global Biodesign Fellowship | Stanford University

Publications

Selected publications

  • "Heritability of the human connectome: A connectotyping study."
    Network Neuroscience, Volume 2, No. 2, Focus Feature: New Trends in Connectomics, p.175-199. Posted Online June 04, 2018

  • "Connectotyping: Model based fingerprinting of the functional connectome."
    PLoS One, vol. 9, no. 11, p. e111048, Nov. 2014.

  • "Bridging the gap between the human and macaque connectome: a quantitative comparison of global interspecies structure-function relationships and network topology." J. Neurosci., vol. 34, no. 16, pp. 5552–63, Apr. 2014.

  • "Firing rate control of a neuron using a linear proportional-integral controller." J Neural Eng, vol. 7, no. 6, p. 66004, Dec. 2010.

Publications

  • "Large-scale topology and the default mode network in the mouse connectome" Proceedings of the National Academy of Sciences of the United States of America December 30 2014
  • "Connectotyping" PLoS One November 11 2014
  • "Bridging the gap between the human and macaque connectome" Journal of Neuroscience  2014
  • "At risk of being risky" Developmental Cognitive Neuroscience April 1 2017
  • "Real-time motion analytics during brain MRI improve data quality and reduce costs" NeuroImage November 1 2017
  • "Firing rate control of a neuron using a linear proportional-integral controller" Journal of Neural Engineering December 1 2010
  • "Parameterized phase response curves for characterizing neuronal behaviors under transient conditions" Journal of Neurophysiology June 7 2013
  • "Dysfunctional Limbic Circuitry Underlying Freezing of Gait in Parkinson's Disease" Neuroscience March 15 2018
  • "Subtyping cognitive profiles in Autism Spectrum Disorder using a Functional Random Forest algorithm" NeuroImage May 15 2018
  • "Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo" Cell Reports April 10 2018
  • "Diet matters" Psychoneuroendocrinology May 1 2018
  • "Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring" Nature Neuroscience April 9 2018
  • "Correlated gene expression and anatomical communication support synchronized brain activity in the mouse functional connectome" Journal of Neuroscience June 20 2018
  • "Individual differences in functional brain connectivity predict temporal discounting preference in the transition to adolescence" Developmental Cognitive Neuroscience November 1 2018
  • "The Heterogeneity Problem" Trends in Cognitive Sciences January 1 2019

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