Photo of Mushui Dai, M.D., Ph.D.

Mushui Dai M.D., Ph.D.

  • (503) 494-7719
    • Associate Professor of Molecular and Medical Genetics School of Medicine
    • Cancer Biology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. Dai’s research focuses on the understanding of the biological function and molecular mechanisms of the p53 tumor suppression and c-Myc oncogenic pathways. Dr. Dai’s prior research has demonstrated that some ribosomal proteins play a critical role in regulating both the MDM2-p53 and c-Myc pathway in response to nucleolar stress. His findings help to understand how ribosomal biogenesis is tightly coordinated with cell cycle progression during normal homeostasis. Currently, Dr. Dai’s lab is investigating (1) the mechanism underlying the RP inhibition of the MDM2-p53 pathway; (2) the mechanism underlying the regulation of c-myc mRNA stability by L11; (3) the role of deubiquitination in controlling p53 protein stability and activity by in response to stress. (4) the role of ubiquitination and deubiquitination in controlling c-Myc protein stability and activity. Dr. Dai’s research would provide important information on how p53 tumor and c-Myc oncoprotein are tightly controlled in both physiological and stress conditions, thereby providing a possible means to manipulate p53 and c-Myc function in cancer cells.

Education

  • M.D., Anhui Medical University China 1988
  • M.Sc., Sun Yat-Set University School of Medicine China 1994
  • Ph.D., Oregon Health & Science University, Portland Oregon 2005

Publications

  • "The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc" Proceedings of the National Academy of Sciences of the United States of America March 24 2015
  • "Enhancing effects of co-transduction of both human erythropoietin receptor and c-kit cDNAs into hematopoietic stem/progenitor cells from cord blood on proliferation and differentiation of erythroid progenitors" Cytokines, Cellular and Molecular Therapy  2000
  • "Introduction of human erythropoiet1n receptor cNA HV retroviral mediated gene transfer into murjne embryonic stem cells enhances erythroid commitment in embryoid bodies" Experimental Hematology  1998
  • "Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress" Molecular and Cellular Biology October 2011
  • "Growth inhibitory effects of large subunit ribosomal proteins in melanoma" Pigment Cell and Melanoma Research  2014
  • "Balance of yin and yang" Neoplasia (United States)  2006
  • "Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy" Current Pharmaceutical Design  2013
  • "Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer" Journal of Cellular Biochemistry October 15 2008
  • "SSRP1 functions as a co-activator of the transcriptional activator p63" EMBO Journal October 15 2002
  • "Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition" Molecular and Cellular Biology September 2004
  • "Inhibition of c-Myc activity by ribosomal protein L11" EMBO Journal July 25 2007
  • "Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF" Journal of Biological Chemistry May 18 2012
  • "Mycophenolic acid activation of p53 requires ribosomal proteins L5 and L11" Journal of Biological Chemistry May 2 2008
  • "Identification and characterization of nuclear and nucleolar localization signals in the adeno-associated virus serotype 2 assembly-activating protein" Journal of Virology  2015
  • "An expansion phase precedes terminal erythroid differentiation of hematopoietic progenitor cells from cord blood in vitro and is associated with up-regulation of cyclin E and cyclin-dependent kinase 2" Blood December 1 2000
  • "Differentially expressed genes during in vitro differentiation of murine embryonic stem cells transduced with a human erythropoietin receptor cDNA" Stem Cells and Development  2000
  • "Feedback regulation of c-Myc by ribosomal protein L11" Cell Cycle November 15 2007
  • "Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1" EMBO Journal February 1 2012
  • "Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation" Journal of Biological Chemistry August 13 2010
  • "MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation" EMBO Journal December 1 2003
  • "Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and Stabilize p53 protein" Journal of Biological Chemistry February 21 2014
  • "Enhancement of proliferation and differentiation of erythroid progenitors by co-transduction of erythropoietin receptor and H-ras cDNAs into single CD343+ cord blood cells" Bone Marrow Transplantation  2000
  • "Co-transduction of cDNAs for c-kit and steel factor into single CD34+ cord blood cells further enhances the growth of erythroid and multipotential progenitors" Stem Cells and Development  2000
  • "MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation" Journal of Biological Chemistry August 23 2002
  • "Introduction of Human Erythropoietin Receptor Complementary DNA by Retrovirus-Mediated Gene Transfer into Murine Embryonic Stem Cells Enhances Erythropoiesis in Developing Embryoid Bodies" Biology of Blood and Marrow Transplantation  2000
  • "Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2" Molecular and Cellular Biology July 2008
  • "Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest" Journal of Biological Chemistry October 6 2006
  • "The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific" Journal of Biological Chemistry July 19 2002
  • "Nucleophosmin is essential for ribosomal protein L5 nuclear export" Molecular and Cellular Biology May 2006
  • "Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression (Journal of Biological Chemistry (2005) 280, (12587-12594))" Journal of Biological Chemistry December 10 2010

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