Photo of Michael Klein, M.D.

Michael Klein M.D.

  • (503) 494-3055
    • Professor of Ophthalmology School of Medicine
    • Casey Eye Institute School of Medicine
    • Ophthalmology School of Medicine

Dr. Klein specializes in retinal disease. His research interests include macular degeneration, retinal vascular diseases and diabetic retinopathy.


  • M.D., Northwestern University Medical School, Chicago Illinois 1966
  • Residency:

    • Ophthalmology-University of Illinois Eye and Ear Infirmary, Chicago
  • Fellowship:

    • Retina-Boston University, Retina-Wilmer Institute, Johns Hopkins, Baltimore
  • Certifications:

    • American Board of Ophthalmology


  • "Inflammation and age-related macular degeneration [6] (multiple letters)" JAMA - Journal of the American Medical Association July 1 2004
  • "A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss" JAMA Ophthalmology  2001
  • "Visual function and the subsequent development of exudative age-related macular degeneration" Investigative Ophthalmology and Visual Science  1992
  • "Natural course of perfused central retinal vein occlusion" Canadian Journal of Ophthalmology  1995
  • "Risk factors for choroidal neovascularization in the second eye of patients with juxtafoveal or subfoveal choroidal neovascularization secondary to age-related macular degeneration" JAMA Ophthalmology  1997
  • "Diagnostic and therapeutic challenges" Retina May 2006
  • "Clinicopathologic correlation of choroidal and retinal neovascular lesions in age-related macular degeneration" American Journal of Ophthalmology January 2011
  • "Lutein/zeaxanthin for the treatment of age-related cataract" JAMA Ophthalmology July 2013
  • "Risk assessment model for development of advanced age-related macular degeneration" JAMA Ophthalmology December 2011
  • "Clinical and pathologic effects of grid macular laser in aged primate eyes containing drusen" Investigative Ophthalmology and Visual Science  1997
  • "Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration" Genes and Immunity December 2010
  • "Analysis of the ARMD1 locus" Human Molecular Genetics December 15 2003
  • "Hemolytic uremic syndrome associated with Purtscher-like retinopathy" JAMA Ophthalmology  1998
  • "Predictors of optical density of lutein and zeaxanthin in retinas of older women in the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women's Health Initiative" American Journal of Clinical Nutrition November 1 2006
  • "Rhesus monkeys and humans share common susceptibility genes for age-related macular disease" Human Molecular Genetics  2008
  • "Age-related macular degeneration" JAMA Ophthalmology August 1998
  • "Discrete expression and distribution pattern of TIMP-3 in the human retina and choroid" Current Eye Research  1997
  • "Natural History of Drusenoid Pigment Epithelial Detachment in Age-Related Macular Degeneration" Ophthalmology March 2010
  • "Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression AREDS2 report no. 3" JAMA Ophthalmology February 2014
  • "Cavernous hemangioma of the retina" Annals of Ophthalmology  1975
  • "Purtscher's-like retinopathy in chronic renal failure" Ophthalmology  1992
  • "Central vein occlusion study" Transactions of the American Ophthalmological Society  1994
  • "Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration" PLoS One May 12 2009
  • "Sorsby fundus dystrophy" JAMA Ophthalmology  1997
  • "Technical Brief" Molecular Vision September 24 2004
  • "Maculopathy in cynomolgus monkeys" JAMA Ophthalmology  1981
  • "Subretinal neovascularization developing after prophylactic argon laser photocoagulation of atrophic macular scars" American Journal of Ophthalmology  1976
  • "Age-related macular degeneration - A genome scan in extended families" American Journal of Human Genetics September 1 2003
  • "Update on the role of genetics in the onset of age-related macular degeneration" Clinical Ophthalmology  2011
  • "Pharmacogenetics for genes associated with age-related macular degeneration in the comparison of AMD treatments trials (CATT)" Ophthalmology March 2013

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