Photo of Michael C. Andresen, Ph.D.

Michael C. Andresen Ph.D.

  • (503) 494-5831
    • Professor of Physiology and Pharmacology School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Our lab is interested in the neurobiology of visceral sensory integration. Our work deals with a portion of the brain that regulates vital organ function called the nucleus of the solitary tract (NTS). Peripheral afferents from the vital organs (e.g. heart, lungs, gut) directly contact NTS neurons. Areas of particular focus include the gating of glutamate release by activation of TRPV1, contrasting control of evoked and spontaneous transmission and the impact of vagal nerve stimulation. High fat diet alters NTS sensory transmission.

Arterial baroreceptors (BR) encode stretch of arteries with each cardiac cycle. This dynamic information  is transmitted to second order neurons in the NTS. We study these NTS neurons and synaptic transmission in brain slices using dyes to visualize the central terminal boutons of BRs within NTS.

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Areas of interest

  • autonomic
  • electrophysiology
  • synaptic transmission

Education

  • B.S., University of California, Irvine 1971
  • M.S., San Diego State University 1973
  • Ph.D., University of Texas Medical Branch 1978

Publications

  • "Neonatal capsaicin treatment permanently eliminates most rat C-type baroreceptors but baroreflex function is preserved" FASEB Journal March 20 1998
  • "Angiotensin potentiates excitatory sensory synaptic transmission to medial solitary tract nucleus neurons" American Journal of Physiology - Renal Fluid and Electrolyte Physiology May 1 2003
  • "Propofol modulates synaptic transmission within medial nucleus tractus solitarius (mNTS)" FASEB Journal  1997
  • "Differential frequency-dependent reflex integration of myelinated and nonmyelinated rat aortic baroreceptors" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  1998
  • "An ionic current model for neurons in the rat medial nucleus tractus solitarii receiving sensory afferent input" Journal of Physiology  1993
  • "Ketamine inhibits sodium currents in identified cardiac parasympathetic neurons in nucleus ambiguus" Anesthesiology  2002
  • "Isoflurane actions on central nervous system and cardiovascular toxicity of bupivacaine in rats" FASEB Journal  1996
  • "Baroreceptor response to modeled aortic pressure"   1999
  • "Cellular mechanisms of baroreceptor integration at the nucleus tractus solitarius" Annals of the New York Academy of Sciences  2001
  • "The unsilent majority-TRPV1 drives "spontaneous" transmission of unmyelinated primary afferents within cardiorespiratory NTS" American Journal of Physiology - Renal Fluid and Electrolyte Physiology December 15 2012
  • "Presynaptic actions of propofol enhance inhibitory synaptic transmission in isolated solitary tract nucleus neurons" Brain Research August 25 2009
  • "Baroreflex frequency-response characteristics to aortic depressor and carotid sinus nerve stimulation in rats" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  1996
  • "Vanilloid receptors presynaptically modulate cranial visceral afferent synaptic transmission in nucleus tractus solitarius" Journal of Neuroscience September 15 2002
  • "Vanilloid-sensitive afferents activate neurons with prominent A-type potassium currents in nucleus tractus solitarius" Journal of Neuroscience September 15 2002
  • "Rapid resetting of baroreceptors and renal baroreflex in conscious rabbits" Federation Proceedings  1984
  • "A-type potassium channels differentially tune afferent pathways from rat solitary tract nucleus to caudal ventrolateral medulla or paraventricular hypothalamus" Journal of Physiology July 2007
  • "Propofol enhances both tonic and phasic inhibitory currents in second-order neurons of the solitary tract nucleus (NTS)" Neuropharmacology March 2008
  • "Paired assessment of volatile anesthetic voncentrations with synaptic actions recorded in vitro" PLoS One October 8 2008
  • "Rapid baroreceptor resetting is unaltered by chronic hypertension in rats" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  1989
  • "Photoresponses of a sensitive extraretinal photoreceptor in Aplysia" Journal of Physiology  1979
  • "The role of diffusion in the photoresponse of an extraretinal photoreceptor of Aplysia" Journal of Physiology  1979
  • "Effects of changes in extracellular ionic concentrations on aortic baroreceptors with nonmyelinated afferent fibers" Circulation Research  1982
  • "Contribution of potassium channels to the discharge properties of rat aortic baroreceptor sensory endings" Brain Research November 28 1994
  • "Diet-induced obesity severely impairs myelinated aortic baroreceptor reflex responses" American Journal of Physiology - Renal Fluid and Electrolyte Physiology May 15 2012
  • "GABAB restrains release from singly-evoked GABA terminals" Neuroscience October 13 2011
  • "Non-NMDA receptors mediate sensory afferent synaptic transmission in medial nucleus tractus solitarius" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  1990
  • "Gadolinium and mechanotransduction of rat aortic baroreceptors" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  1992
  • "Peptidergic modulation of mechanotransduction in rat arterial baroreceptors" Circulation Research  1990
  • "Propofol Modulates γ-Aminobutyric Acid-mediated Inhibitory Neurotransmission to Cardiac Vagal Neurons in the Nucleus Ambiguus" Anesthesiology May 2004
  • "Differential Distribution and Function of Hyperpolarization-Activated Channels in Sensory Neurons and Mechanosensitive Fibers" Journal of Neuroscience March 31 2004

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