Matthew Wood earned his MD and a PhD in pharmacology and toxicology at Dartmouth Medical School in Hanover, New Hampshire. His graduate work with Dr. Yolanda Sanchez involved modeling the genetic defect of neurofibromatosis type 1 in budding yeast in order to create a novel drug screening platform. He then completed his residency in anatomic pathology and neuropathology fellowship at University of California, San Francisco, where he developed an interest in the molecular classification of brain tumors. He continued as a postdoctoral research fellow at the UCSF Brain Tumor Research Center, working with Dr. Russ Pieper, as part of an NIH-funded training program in translational brain tumor research.
Dr. Wood's research interests are in advancing molecular diagnostic approaches to brain tumors. He provides neuropathology support for collaborations with neurosurgery and pediatric neurology.Read more
Areas of interest
- Diagnostic surgical and autopsy neuropathology
- Using molecular testing to characterize brain tumors to enable the best possible disease classification, prognostication, and treatment.
- B.S., Carnegie Mellon University, Pittsburgh Pennsylvania United States 2002
- M.D., Ph.D., Geisel School of Medicine at Dartmouth, Hanover New Hampshire United States 2012
- Pathology Resident, University of California San Francisco, 2012-2014
- Neuropathology Fellow, University of California San Francisco, 2014-2016
- Anatomic Pathology (ABP), 2016
- Neuropathology (ABP), 2016
Wood MD, Tihan T, Perry AJ, Chacko G, Turner C, Pu C, Payne C, Yu A, Bannykh S, Solomon DA. "Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities." Brain Pathol. 2017 Sep 28. PMID: 28960623.
Wood MD, Reis GF, Reuss DE, Phillips JJ. "Protein Analysis of Glioblastoma Primary and Posttreatment Pairs Suggests a Mesenchymal Shift at Recurrence." J Neuropathol Exp Neurol. 2016 Oct;75(10):925-935. PMID: 27539476.
Wood M, Rawe M, Johansson G, Pang S, Soderquist RS, Patel AV, Nelson S, Seibel W, Ratner N, Sanchez Y. "Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells." Mol Cancer Ther. 2011 Sep;10(9):1740-50. PMID: 21697395.
Wood MD, Sanchez Y. "Deregulated Ras signaling compromises DNA damage checkpoint recovery in S. cerevisiae." Cell Cycle. 2010 Aug 15;9(16):3353-63. PMID: 20716966.
Hayes J, Yu Y, Jalbert LE, Mazor T, Jones LE, Wood MD, Walsh KM, Bengtsson H, Hong C, Oberndorfer S, Roetzer T, Smirnov IV, Clarke JL, Aghi MK, Chang SM, Nelson SJ, Woehrer A, Phillips JJ, Solomon DA, Costello JF. "Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas." Neuro Oncol. 2017 Oct 25. PMID: 29077933.
Rutkowski MJ, Birk HS, Wood M, Perry A, Nicolaides T, Ames CP, Gupta N. "Metastatic clival chordoma: a case report of multiple extraneural metastases following resection and proton beam radiotherapy in a 5-year old boy." J Neurosurg Pediatr. 2017 May;19(5):531-537. PMID: 28304223.
Ohba S, Mukherjee J, Johannessen TC, Mancini A, Chow TT, Wood M, Jones L, Mazor T, Marshall RE, Viswanath P, Walsh KM, Perry A, Bell RJ, Phillips JJ, Costello JF, Ronen SM, Pieper RO. "Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process." Cancer Res. 2016 Nov 15;76(22):6680-6689. PMID: 27758882.
Fontana MF, Baccarella A, Craft JF, Boyle MJ, McIntyre TI, Wood MD, Thorn KS, Anidi C, Bayat A, Chung MR, Hamburger R, Kim CY, Pearman E, Pham J, Tang JJ, Boon L, Kamya MR, Dorsey G, Feeney ME, Kim CC. "A Novel Model of Asymptomatic Plasmodium Parasitemia That Recapitulates Elements of the Human Immune Response to Chronic Infection." PLoS One. 2016;11(9):e0162132. PMID: 27583554;PMCID: PMC5008831.
Gospodarev V, Câmara J, Chakravarthy V, Perry A, Wood M, Dietz R, Wang J, De Los Reyes K, Raghavan R. "Treatment of IgG4-related pachymeningitis in a patient with steroid intolerance: The role of early use of rituximab." J Neuroimmunol. 2016 Oct 15;299:62-65. PMID: 27725123.