Matthew H. Brush

  • Research Assistant Professor, Library
  • Senior Research Associate, Ontology Development Group, Library


Major Responsibilities
Ontology development, data modeling, and curation for Monarch Initiative, eagle-I, and CTSA Connect projects

Development of best-practices and documentation for community ontology engineering and data curation

Active development, coordination, and integration of broader community ontology efforts


  • B.S., 2000, Notre Dame
  • Ph.D., 2005, Duke University


Selected publications

  • Vasilevsky NA, Brush MH, Paddock H, Ponting L, Tripathy SJ, LaRocca GM, Haendel MA. (2013) On the reproducibility of science: unique identification of research resources in the biomedical literature. PeerJ 1:e148
  • Nicole Vasilevsky, Tenille Johnson, Karen Corday, Carlo Torniai, Matthew Brush, Erik Segerdell, Melanie Wilson, Chris Shaffer, David Robinson and Melissa Haendel Research Resources: Curating the new eagle-i discovery system, Database, Volume 2012, 2012, doi: 10.1093/database/bar067
  • Zhou W*, Brush MH*, Choy MS, Shenolikar S., Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein.  J Biol Chem. 2011 Jun 17;286(24):21687-96. Epub 2011 Apr 25. (* co-first author)
  • Aslan JE,  You H, Williamson DM, Endig J, Shu H, Du Y, Milewski RL, Youker RT,  Thomas L, Brush MH, Possemato A, Sprott K, Fu H, Greis KD, Runckel DN, Vogel A and Thomas G.  Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with Apo2L/TRAIL-induced apoptosis. Mol Cell. 2009 May 14;34(4):497-509
  • Brush MH, Shenolikar S. Control of cellular GADD34 levels by the 26S proteasome.  (2008) Mol Cell Biol. Dec;28(23):6989-7000.
  • Voltz JW, Brush M, Sikes S, Steplock D, Weinman EJ, Shenolikar S. Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets. (2007) J Biol Chem. Nov 16;282(46):33879-87.
  • Hagerty L, Weitzel DH, Chambers J, Fortner CN, Brush MH, Loiselle D, Hosoya H, Haystead TA. ROCK1 phosphorylates and activates zipper-interacting protein kinase (2007) J Biol Chem.. Feb 16;282(7):4884-93.
  • Roadcap DW, Brush MH, and Shenolikar S. Identification of Protein Phosphatase-1 Regulators. (2006) Methods in Molecular Biology 365:181-96.
  • Brush MH, Guardiola A, Connor JH , Yao TP, and Shenolikar S. Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. (2004)  J Biol Chem. 279:7685-91.
  • Brush MH, Weiser DC, and Shenolikar S. GADD34 Targets Protein Phosphatase-1 to the endoplasmic reticulum to facilitate the dephosphorylation of the eukaryotic initiation factor, eIF2α (2003) Mol Cell Biol. 23:1292-303.


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