Matt Whorton, Ph.D., is an assistant scientist at the Vollum Institute. He graduated from Duke University in 2001 with a B.S. in Biology, and went on to obtain a Ph.D. in Pharmacology from the University of Michigan in 2008. He did postdoctoral research at Rockefeller University before joining the Vollum in 2013.
The Whorton Lab is interested in understanding detailed mechanisms of how membrane proteins—ion channels, transporters, and receptors—function. Cells have developed many ways to get nutrients, ions, and signaling information across the barrier of the lipid membrane. This places membrane proteins as central players in many physiological processes and makes them important drug targets.
Areas of interest
- x-ray crystallography
- ion channels and transporters
- structural biology
- signal transduction
- membrane proteins
- B.S., Duke University, Durham North Carolina 2001
- Ph.D., University of Michigan, Ann Arbor Michigan 2008
Honors and awards
- American Asthma Foundation Scholar Award (2016)
- "Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating." eLife In: , Vol. 6, e24149, 16.01.2017.
- "Calcium-activated proteins visualized." Nature In: , Vol. 516, No. 7530, 11.12.2014, p. 176-178.
- "Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system." eLife In: , Vol. 3, 2014, p. e03671.
- "X-ray structure of the mammalian GIRK2-βγ G-protein complex." Nature In: , Vol. 498, No. 7453, 2013, p. 190-197.
- "Crystal structure of the mammalian GIRK2 K + channel and gating regulation by G proteins, PIP 2, and sodium." Cell In: , Vol. 147, No. 1, 30.09.2011, p. 199-208.
- "The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 106, No. 23, 09.06.2009, p. 9501-9506.
- "Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer." Journal of Biological Chemistry In: , Vol. 283, No. 7, 15.02.2008, p. 4387-4394.
- "A CE assay for the detection of agonist-stimulated adenylyl cyclase activity." Electrophoresis In: , Vol. 28, No. 12, 06.2007, p. 1913-1920.
- "A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 104, No. 18, 01.05.2007, p. 7682-7687.
- "SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 104, No. 6, 06.02.2007, p. 1805-1810.
- "ARF6 activation by Gαq signaling : Gαq forms molecular complexes with ARNO and ARF6." Cellular Signalling In: , Vol. 18, No. 11, 11.2006, p. 1988-1994.
- "Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues." Journal of Biological Chemistry In: , Vol. 280, No. 9, 04.03.2005, p. 7712-7719.
- "Chemical and Functional Analysis of Hydroxyurea Oral Solutions." Journal of Pediatric Hematology/Oncology In: , Vol. 26, No. 3, 03.2004, p. 179-184.
- "Identification of Hemochromatosis Gene Polymorphisms in Chronically Transfused Patients with Sickle Cell Diseases." American Journal of Hematology In: , Vol. 74, No. 4, 12.2003, p. 243-248.
- "Adenylyl Cyclases." Handbook of Cell Signaling. Vol. 2-3 Elsevier Inc., 2003. p. 419-426.
- "Thrombophilic DNA mutations as independent risk factors for stroke and avascular necrosis in sickle cell anemia." Hematology In: , Vol. 6, No. 5, 2001, p. 347-353.