Photo of Mary L. Wirtz, Ph.D.

Mary L. Wirtz Ph.D.

    • Research Associate Professor of Ophthalmology School of Medicine
    • Molecular Microbiology and Immunology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Publications

  • "Investigation of founder effects for the Thr377Met Myocilin mutation in glaucoma families from differing ethnic backgrounds" Molecular Vision  2007
  • "Gyrate atrophy of the choroid and retina" American Journal of Human Genetics  1989
  • "A large GLC1C Greek family with a myocilin T377M mutation" Investigative Ophthalmology and Visual Science February 2006
  • "Age-related macular degeneration" JAMA Ophthalmology August 1998
  • "Discrete expression and distribution pattern of TIMP-3 in the human retina and choroid" Current Eye Research  1997
  • "Proteoglycan expression by human trabecular meshworks" Current Eye Research  1997
  • "A cysteine for glycine substitution at position 1017 in an α1(I) chain of type I collagen in a patient with mild dominantly inherited osteogenesis imperfecta" Molecular Biology and Medicine  1988
  • "The genetic loci of open-angle glaucoma" Ophthalmology Clinics of North America December 2003
  • "Expression profile and genome location of cDNA clones from an infant human trabecular meshwork cell library" Investigative Ophthalmology and Visual Science December 1 2002
  • "Primary open angle glaucoma due to T377M MYOC" Clinical Ophthalmology  2010
  • "Myocilin variations and familial glaucoma in Taxiarchis, a small Greek village" Molecular Vision April 25 2008
  • "Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma" Journal of Ocular Pharmacology and Therapeutics March 1 2014
  • "Weill-Marchesani syndrome - Possible linkage of the autosomal dominant form to 15q21.1" American Journal of Medical Genetics, Part A October 2 1996
  • "The path to open-angle glaucoma gene discovery" Investigative Ophthalmology and Visual Science July 2010
  • "Association of POAG risk factors and the Thr377met MYOC mutation in an isolated greek population" Investigative Ophthalmology and Visual Science June 2010
  • "Delineation of the catalytic components of the NADPH-dependent O2- generating oxidoreductase of human neutrophils" Biochemical and Biophysical Research Communications February 10 1983
  • "Refining the primary open-angle glaucoma GLC1C region on chromosome 3 by haplotype analysis" Clinical Genetics January 2004
  • "In vivo and in vitro noncovalent association of excised α1(i) amino-terminal propeptides with mutant pnα2(I) collagen chains in native mutant collagen in a case of Ehlers-Danlos syndrome, type VII" Journal of Biological Chemistry  1990
  • "A cysteine for glycine substitution at position 175 in an α1 (i) chain of type I collagen produces a clinically heterogeneous form of osteogenesis imperfecta" Connective Tissue Research  1993
  • "Prospects for genetic intervention in primary open-angle glaucoma" Drugs and Aging  1998
  • "Clinical Features Associated With an Asp380His Myocilin Mutation in a US Family With Primary Open-Angle Glaucoma" American Journal of Ophthalmology July 2007
  • "Malattia leventinese" American Journal of Ophthalmology September 1998
  • "Weill-Marchesani syndrome" Investigative Ophthalmology and Visual Science February 15 1996
  • "TIMP3 expression in the human retina and choroid" Investigative Ophthalmology and Visual Science February 15 1996
  • "Heterogeneity and complementation analysis of fibroblasts from vitamin B6 responsive and non-responsive patients with gyrate atrophy of the choroid and retina" Journal of Inherited Metabolic Disease June 1985
  • "Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q" American Journal of Human Genetics February 1997
  • "Repeated helical epitopes of defined amino acid sequence in human type III collagen identified by monoclonal antibodies" Molecular Immunology  1992
  • "Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells" Molecular Vision July 25 2013
  • "Variants in ASB10 are associated with open-angle glaucoma" Human Molecular Genetics March 2012
  • "Identification and expression of a novel type I procollagen C-proteinase enhancer protein gene from the glaucoma candidate region on 3q21-q24" Genomics June 15 2000

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