Photo of Martina Ralle, Ph.D.

Martina Ralle Ph.D.

  • (503) 494-3225
    • Associate Professor of Molecular and Medical Genetics School of Medicine
    • Associate Professor of Molecular and Medical Genetics School of Medicine
    • Director USR Elemental Analysis Core
    • Molecular and Medical Genetics Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Areas of interest

  • The role of trace elements in neurodegenerative diseases
  • Trace metal imaging
  • Tool development for X-ray fluorescence microscopy
  • Cellular metal homeostasis
  • Elemental analysis of biological specimen

Education

  • Ph.D., University of Bonn Germany, Bonn, Nordrhein-Westfalen Germany 1993

Honors and awards

  • Feodor-Lynen Fellowship

Memberships and associations

  • American Chemical Society
  • American Society for Biochemistry and Molecular Biology
  • American Association for the Advancement of Science

Publications

  • "Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- And cisplatin-binding ecto-domain" Proceedings of the National Academy of Sciences of the United States of America November 12 2013
  • "The selenocysteine-substituted blue copper center" Journal of the American Chemical Society June 16 2004
  • "X-ray powder diffraction data and thermal expansion of N(CH3)4Br and N(CH3)4I" Powder Diffraction September 1996
  • "In vivo and in vitro analyses of amygdalar function reveal a role for copper" Journal of Neurophysiology  2014
  • "The N-terminal Metal-binding Site 2 of the Wilson's Disease Protein Plays a Key Role in the Transfer of Copper from Atox1" Journal of Biological Chemistry April 9 2004
  • "Selenomethionine-substituted Thermus thermophilus cytochrome ba3" Biochemistry June 1 1999
  • "The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylation" Biochemistry June 23 2009
  • "Nutrigenomics analysis reveals that copper deficiency and dietary sucrose up-regulate inflammation, fibrosis and lipogenic pathways in a mature rat model of nonalcoholic fatty liver disease" Journal of Nutritional Biochemistry October 1 2015
  • "Temperature dependent Rh ⋯ Rh EXAFS in dinuclear and adsorbed rhodium species" Journal of the American Chemical Society May 31 1995
  • "Biological X-ray fluorescence microscopy" Microscopy and Microanalysis August 1 2014
  • "Major changes in copper coordination accompany reduction of peptidylglycine monooxygenase" Journal of Biological Inorganic Chemistry June 2000
  • "High serum Cu and Cu/Zn ratios correlate with impairments in bone density, physical performance and overall health in a population of elderly men with frailty characteristics" Experimental Gerontology July 2012
  • "Modulation of tau phosphorylation by environmental copper" Translational Neurodegeneration November 17 2014
  • "Genetic determinants of amidating enzyme activity and its relationship with metal cofactors in human serum" BMC Endocrine Disorders July 15 2014
  • "Quantitative imaging of metals in tissues" BioMetals February 2009
  • "Gender effects on plasma and brain copper" International Journal of Alzheimer's Disease  2011
  • "Synthesis and Crystal Structure Determination of LaAuO3 " Journal of Solid State Chemistry August 1993
  • "A copper-lowering strategy attenuates amyloid pathology in a transgenic mouse model of Alzheimer's disease" Journal of Alzheimer's Disease  2010
  • "Large scale production of the copper enzyme peptidylglycine monooxygenase using an automated bioreactor" Protein Expression and Purification January 2007
  • "Oral zinc reduces amyloid burden in Tg2576 mice" Journal of Alzheimer's Disease  2014
  • "Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity" Journal of Neurochemistry December 2013
  • "Heterobinucleating ligand-induced structural and chemical variations in [(L)Fe(III)-O-Cu(II)]+ μ-oxo complexes [9]" Journal of the American Chemical Society September 23 1998
  • "High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease" Journal of Biological Chemistry March 16 2007
  • "Elevated copper remodels hepatic RNA processing machinery in the mouse model of Wilson's disease" Journal of Molecular Biology February 11 2011
  • "Using XAS and SXRF to study copper in wilson disease at the molecular and tissue level"   2007
  • "Phytic acid as a potential treatment for Alzheimer's pathology" Journal of Alzheimer's Disease  2011
  • "Copper transfer to the N-terminal domain of the Wilson disease protein (ATP7B)" Journal of Inorganic Biochemistry May 2004
  • "X-ray absorption spectroscopy of the copper chaperone HAH1 reveals a linear two-coordinate Cu(I) center capable of adduct formation with exogenous thiols and phosphines" Journal of Biological Chemistry June 20 2003
  • "Peroxo-, oxo-, and hydroxo-bridged dicopper complexes" Journal of the American Chemical Society December 16 1998
  • "Spectroscopic Characterization of an Engineered Purple CuA Center in Azurin" Inorganic Chemistry  1998

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