Martin Pike, Ph.D., focuses his research on the pathophysiology of brain diseases, including malignant glioma and stroke, using MRI/MRS in tandem with other approaches. His lab employs dynamic contrast MRI approaches to investigate anti-angiogenic/anti-tumor treatment strategies employing mouse models of malignant glioma. Dr. Pike’s team is currently developing novel combinational treatment strategies for malignant glioma which exploit autophagic cell death. These are implemented in combination with immunohistological analyses and in vitro assessments of underlying mechanisms.
Dr. Pike's goal is to develop effective molecularly targeted combination treatment strategies that will provide hope for patients with malignant glioma. His group is also investigating stroke neuroprotection strategies and using MR based molecular imaging approaches to investigate stroke related inflammation.
Dr. Pike completed his bachelor’s from Williams College in Williamstown, Massachusetts in 1978 and his doctorate in chemistry from the State University of New York in 1985. He was an NIH Postdoctoral Fellow at The Johns Hopkins University School of Medicine, Division of Cardiology in Baltimore, Maryland and, from 1988 to 2008, was a faculty member at the Department of Medicine, division of cardiovascular disease and the Department of Cell Biology at the University of Alabama at Birmingham. He joined OHSU as a visiting scholar at the Advanced Imaging Research Center in 2007 and became a research associate professor at the OHSU Knight Cancer Institute in 2008.Read more
Areas of interest
- Dynamic contrast MRI
- Magnetic resonance imaging
- Ph.D., State University of New York 1985
- NIH Postdoctoral Fellow, Johns Hopkins University School of Medicine, Division of Cardiology in Baltimore, MD, 1985-88
- "Aquaporin-4-dependent glymphatic solute transport in the rodent brain." eLife In: , Vol. 7, e40070, 01.12.2018.
- "Rearing environment influences boldness and prey acquisition behavior, and brain and lens development of bull trout." Environmental Biology of Fishes In: , 16.12.2017, p. 1-19.
- "High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 36, No. 7, 01.07.2016, p. 1257-1270.
- "High-dose estrogen treatment at reperfusion reduces lesion volume and accelerates recovery of sensorimotor function after experimental ischemic stroke." Brain Research In: , Vol. 1639, 15.05.2016, p. 200-213.
- "Synergistic antivascular and antitumor efficacy with combined cediranib and SC6889 in intracranial mouse glioma." PLoS One In: , Vol. 10, No. 12, 0144488, 01.12.2015.
- "Soluble Epoxide Hydrolase in Hydrocephalus, Cerebral Edema, and Vascular Inflammation after Subarachnoid Hemorrhage." Stroke In: , Vol. 46, No. 7, 04.07.2015, p. 1916-1922.
- "Neurobehavioral and Imaging Correlates of Hippocampal Atrophy in a Mouse Model of Vascular Cognitive Impairment." Translational Stroke Research In: , Vol. 6, No. 5, 05.06.2015, p. 390-398.
- "Combined efficacy of cediranib and quinacrine in glioma is enhanced by hypoxia and causally linked to autophagic vacuole accumulation." PLoS One In: , Vol. 9, No. 12, e114110, 09.12.2014.
- "Cancer nanomedicine." Journal of Nanomaterials In: , Vol. 2013, 353941, 2013.
- "Quinacrine synergistically enhances the antivascular and antitumor efficacy of cediranib in intracranial mouse glioma." Neuro-Oncology In: , Vol. 15, No. 12, 2013, p. 1673-1683.
- "Estradiol modulates post-ischemic cerebral vascular remodeling and improves long-term functional outcome in a rat model of stroke." Brain Research In: , Vol. 1461, 21.06.2012, p. 76-86.
- "Dynamic-contrast-enhanced-MRI with extravasating contrast reagent : Rat cerebral glioma blood volume determination." Journal of Magnetic Resonance In: , Vol. 206, No. 2, 10.2010, p. 190-199.
- "A new model of cortical stroke in the rhesus macaque." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 29, No. 6, 06.2009, p. 1175-1186.
- "Dynamic MRI using iron oxide nanoparticles to assess early vascular effects of antiangiogenic versus corticosteroid treatment in a glioma model." Journal of Cerebral Blood Flow and Metabolism In: , Vol. 29, No. 4, 04.2009, p. 853-860.
- "High-resolution longitudinal assessment of flow and permeability in mouse glioma vasculature : Sequential small molecule and SPIO dynamic contrast agent MRI." Magnetic Resonance in Medicine In: , Vol. 61, No. 3, 03.2009, p. 615-625.
- "Effects of G207, a conditionally replication-competent oncolytic herpes simplex virus, on the developing mammalian brain." Journal of NeuroVirology In: , Vol. 13, No. 2, 03.2007, p. 118-129.
- "Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus." Development In: , Vol. 132, No. 23, 12.2005, p. 5329-5339.
- "Fasudil prevents KATP channel-induced improvement in postischemic functional recovery." American Journal of Physiology - Heart and Circulatory Physiology In: , Vol. 288, No. 6 57-6, 06.2005.
- "Early reperfusion levels of Na+ and Ca2+ are strongly associated with postischemic functional recovery but are disassociated from KATP channel-induced cardioprotection." Journal of Molecular and Cellular Cardiology In: , Vol. 37, No. 2, 08.2004, p. 483-496.
- "The effect of KATP channel activation on myocardial cationic and energetic status during ischemia and reperfusion : Role in cardioprotection." Journal of Molecular and Cellular Cardiology In: , Vol. 33, No. 3, 2001, p. 545-560.
- "Simultaneous multicompartment intracellular Ca2+ measurements in the perfused heart using 19F NMR spectroscopy." Magnetic Resonance in Medicine In: , Vol. 35, No. 5, 05.1996, p. 640-647.
- "23Na and 31P nuclear magnetic resonance studies of ischemia-induced ventricular fibrillation : Alterations of intracellular Na+ and cellular energy." Circulation Research In: , Vol. 77, No. 2, 08.1995, p. 394-406.
- "Acylcarnitine accumulation does not correlate with reperfusion recovery in palmitate-perfused rat hearts." American Journal of Physiology - Heart and Circulatory Physiology In: , Vol. 268, No. 6 37-6, 1995.
- "Nuclear magnetic resonance studies of cationic and energetic alterations with oxidant stress in the perfused heart : Modulation with pyruvate and lactate." Circulation Research In: , Vol. 77, No. 4, 1995, p. 773-783.
- "Ischemic dysfunction and impaired recovery in hypertensive hypertrophied hearts is associated with exaggerated intracellular sodium accumulation." American Journal of Hypertension In: , Vol. 7, No. 8, 08.1994, p. 745-754.
- " 1H-NMR spectroscopy can accurately quantitate the lipolysis and oxidation of cardiac triacylglycerols." Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism In: , Vol. 1169, No. 2, 11.08.1993, p. 176-182.
- "The Functional Recovery of Post-Ischemic Myocardium Requires Glycolysis During Early Reperfusion." Journal of Molecular and Cellular Cardiology In: , Vol. 25, No. 3, 03.1993, p. 261-276.
- "NMR measurements of Na+ and cellular energy in ischemic rat heart : Role of Na+-H+ exchange." American Journal of Physiology - Heart and Circulatory Physiology In: , Vol. 265, No. 6 34-6, 1993.
- " 23Na-NMR measurements of intracellular sodium in intact perfused ferret hearts during ischemia and reperfusion." American Journal of Physiology - Heart and Circulatory Physiology In: , Vol. 259, No. 6 28-6, 1990.
- "Quantification of [Ca2+](i) in perfused hearts. Critical evaluation of the 5F-BAPTA and nuclear magnetic resonance method as applied to the study of ischemia and reperfusion." Circulation Research In: , Vol. 66, No. 5, 1990, p. 1255-1267.