Photo of Martin M. Pike, Ph.D.

Martin M. Pike Ph.D.

  • Portland Campus

    • Associate Professor Advanced Imaging Research Center
    • Biomedical Engineering Graduate Program School of Medicine

Martin Pike, Ph.D., focuses his research on the pathophysiology of brain diseases, including malignant glioma and stroke, using MRI/MRS in tandem with other approaches. His lab employs dynamic contrast MRI approaches to investigate anti-angiogenic/anti-tumor treatment strategies employing mouse models of malignant glioma. Dr. Pike’s team is currently developing novel combinational treatment strategies for malignant glioma which exploit autophagic cell death. These are implemented in combination with immunohistological analyses and in vitro assessments of underlying mechanisms.

Dr. Pike's goal is to develop effective molecularly targeted combination treatment strategies that will provide hope for patients with malignant glioma. His group is also investigating stroke neuroprotection strategies and using MR based molecular imaging approaches to investigate stroke related inflammation.

Dr. Pike completed his bachelor’s from Williams College in Williamstown, Massachusetts in 1978 and his doctorate in chemistry from the State University of New York in 1985. He was an NIH Postdoctoral Fellow at The Johns Hopkins University School of Medicine, Division of Cardiology in Baltimore, Maryland and, from 1988 to 2008, was a faculty member at the Department of Medicine, division of cardiovascular disease and the Department of Cell Biology at the University of Alabama at Birmingham. He joined OHSU as a visiting scholar at the Advanced Imaging Research Center in 2007 and became a research associate professor at the OHSU Knight Cancer Institute in 2008.

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Areas of interest

  • Glioma
  • Dynamic contrast MRI
  • Magnetic resonance imaging

Education

  • Ph.D., State University of New York 1985
  • Fellowship:

    • NIH Postdoctoral Fellow, Johns Hopkins University School of Medicine, Division of Cardiology in Baltimore, MD, 1985-88

Publications

  • "Dynamic-contrast-enhanced-MRI with extravasating contrast reagent" Journal of Magnetic Resonance October 2010
  • "Aqueous shift reagents for high-resolution cationic nuclear magnetic resonance. 2. 25Mg, 39K, and 23Na resonances shifted by chelidamate complexes of dysprosium(III) and thulium(III)" Inorganic Chemistry  1983
  • "Cancer nanomedicine" Journal of Nanomaterials  2013
  • " 23Na-NMR measurements of intracellular sodium in intact perfused ferret hearts during ischemia and reperfusion" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  1990
  • "Aqueous shift reagents for high-resolution cationic nuclear magnetic resonance. III. Dy(TTHA)3-, Tm(TTHA)3-, and Tm(PPP)2 7- " Journal of Magnetic Resonance (1969)  1984
  • "High-resolution NMR studies of transmembrane cation transport" Proceedings of the National Academy of Sciences of the United States of America  1982
  • "Early reperfusion levels of Na+ and Ca2+ are strongly associated with postischemic functional recovery but are disassociated from KATP channel-induced cardioprotection" Journal of Molecular and Cellular Cardiology August 2004
  • "High-resolution 23Na-NMR studies of human erythrocytes" American Journal of Physiology - Renal Fluid and Electrolyte Physiology May 1984
  • "Dynamic MRI using iron oxide nanoparticles to assess early vascular effects of antiangiogenic versus corticosteroid treatment in a glioma model" Journal of Cerebral Blood Flow and Metabolism April 2009
  • "Neurobehavioral and Imaging Correlates of Hippocampal Atrophy in a Mouse Model of Vascular Cognitive Impairment" Translational Stroke Research June 5 2015
  • "The Functional Recovery of Post-Ischemic Myocardium Requires Glycolysis During Early Reperfusion" Journal of Molecular and Cellular Cardiology March 1993
  • "Estradiol modulates post-ischemic cerebral vascular remodeling and improves long-term functional outcome in a rat model of stroke" Brain Research June 21 2012
  • "High-resolution 23Na-NMR studies of human erythrocytes" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  1984
  • "NMR study of rat diaphragm exposed to metabolic and compensated metabolic acidosis" Journal of Applied Physiology  1988
  • "Quantification of [Ca2+](i) in perfused hearts. Critical evaluation of the 5F-BAPTA and nuclear magnetic resonance method as applied to the study of ischemia and reperfusion" Circulation Research  1990
  • " 23Na and 39K nuclear magnetic resonance studies of perfused rat hearts. Discrimination of intra- and extracellular ions using a shift reagent" Biophysical Journal  1985
  • "Fasudil prevents KATP channel-induced improvement in postischemic functional recovery" American Journal of Physiology - Renal Fluid and Electrolyte Physiology June 2005
  • "Sodium transport and phosphorus metabolism in sodium-loaded yeast" Biochemistry  1987
  • "Combined efficacy of cediranib and quinacrine in glioma is enhanced by hypoxia and causally linked to autophagic vacuole accumulation" PLoS One December 9 2014
  • " 1H-NMR spectroscopy can accurately quantitate the lipolysis and oxidation of cardiac triacylglycerols" Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids August 11 1993
  • "Acylcarnitine accumulation does not correlate with reperfusion recovery in palmitate-perfused rat hearts" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  1995
  • "23Na and 31P nuclear magnetic resonance studies of ischemia-induced ventricular fibrillation" Circulation Research August 1995
  • "High-resolution longitudinal assessment of flow and permeability in mouse glioma vasculature" Magnetic Resonance in Medicine March 2009
  • "Quinacrine synergistically enhances the antivascular and antitumor efficacy of cediranib in intracranial mouse glioma" Neuro-Oncology  2013
  • "Use of shift reagents for nuclear magnetic resonance studies of the kinetics of ion transfer in cells and perfused hearts." Circulation November 1985
  • "Simultaneous multicompartment intracellular Ca2+ measurements in the perfused heart using 19F NMR spectroscopy" Magnetic Resonance in Medicine May 1996
  • "Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus" Development (Cambridge) December 2005
  • "The effect of KATP channel activation on myocardial cationic and energetic status during ischemia and reperfusion" Journal of Molecular and Cellular Cardiology  2001
  • "Nuclear magnetic resonance studies of cationic and energetic alterations with oxidant stress in the perfused heart" Circulation Research  1995
  • "Ischemic dysfunction and impaired recovery in hypertensive hypertrophied hearts is associated with exaggerated intracellular sodium accumulation" American Journal of Hypertension August 1994

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