Photo of Marjorie R. Grafe, M.D., Ph.D.

Marjorie R. Grafe M.D., Ph.D.

  •      (503) 494-8276
    • Professor of Pathology School of Medicine
    • Vice Chair, Education
    • Medical Director, Neuropathology
    • Program Director, Neuropathology Fellowship

Dr. Grafe received her medical degree from Stanford University and her Ph.D. in neurosciences from the University of Florida. She completed residency training in anatomic pathology and neuropathology at the University of California, San Diego. She has been active in resident, medical student and graduate student education. Her primary research interest is the pathobiology of hypoxicischemic brain injury, particularly in the perinatal period.


  • B.A., Stanford University, Stanford California 1976
  • Ph.D., University of Florida, Gainesville Florida 1981
  • M.D., Stanford University, Standford California 1985
  • Residency:

    • Anatomic Pathology, University of California, San Diego 1985-1986
    • Neuropathology, University of California, San Diego 1986-1988
  • Fellowship:

    • Neuropathology, University of California, San Diego 1986-1988
  • Certifications:

    • Anatomic and Neuropathology (American Board of Pathology), 1990


  • "Developmental factors affecting regeneration in the central nervous system" Journal of Neuroscience  1983
  • "Effects of MK-801 upon neurologic outcome following cardiac arrest in cats" Anesthesiology Review  1988
  • "Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke" Journal of Cerebral Blood Flow and Metabolism November 2011
  • "Recombinant TCR ligand reverses clinical signs and CNS damage of EAE induced by recombinant human MOG" Journal of NeuroImmune Pharmacology June 2010
  • "In vivo optical imaging of revascularization after brain trauma in mice" Microvascular Research January 2011
  • "Developmental changes in the topographical distribution of cells contributing to the lateral olfactory tract." Brain Research March 1982
  • "Monkey model of complete global ischemia [2]" Stroke  1993
  • "Novel histopathologic findings in molecularly-confirmed pantothenate kinase-associated neurodegeneration" Brain April 2011
  • "Inheritance of febrile seizures in sudden unexplained death in toddlers" Pediatric Neurology April 2012
  • "The cerebellum" American Journal of Neuroradiology  1990
  • "Neuropathology of the near-term and midgestation ovine fetal brain after sustained in utero hypoxemia" American Journal of Obstetrics and Gynecology  1994
  • "Estradiol after cardiac arrest and cardiopulmonary resuscitation is neuroprotective and mediated through estrogen receptor-β" Journal of Cerebral Blood Flow and Metabolism February 2009
  • "Effects of Androgens on Early Post-ischemic Neurogenesis in Mice" Translational Stroke Research  2014
  • "Contribution of GPR30 for 1,25 dihydroxyvitamin D 3 protection in EAE" Metabolic Brain Disease March 2012
  • "A comparison of the cerebral protective effects of isoflurane and mild hypothermia in a model of incomplete forebrain ischemia in the rat" Anesthesiology  1992
  • "Safety evaluation of intrathecal substance P-Saporin, a targeted neurotoxin, in dogs" Toxicological Sciences May 2006
  • "Human immunodeficiency virus (HIV) and JC virus in acquired immune deficiency syndrome (AIDS) patients with progressive multifocal leukoencephalopathy" Acta Neuropathologica July 1988
  • "High autopsy rates at a university medical center" Archives of Pathology and Laboratory Medicine August 1996
  • "Short- and long-term behavioral effects of exposure to 21%, 40% and 100% oxygen after perinatal hypoxia-ischemia in the rat" International Journal of Developmental Neuroscience October 2011
  • "Differential NF-κB regulation of bcl-x gene expression in hippocampus and basal forebrain in response to hypoxia" Journal of Neuroscience Research May 1 2001
  • "Biphasic changes in the levels of poly(ADP-ribose) polymerase-1 and caspase 3 in the immature brain following hypoxia-ischemia" International Journal of Developmental Neuroscience December 2005
  • "Pharmacology and toxicology of chronically infused epidural clonidine·HCL in dogs" Toxicological Sciences October 1994
  • "Strain-specific differences in perinatal rodent oligodendrocyte lineage progression and its correlation with human" Developmental Neuroscience October 2011
  • "Evaluation of spinal toxicity and long-term spinal reflex function after intrathecal levobupivaciane in the neonatal rat" Anesthesiology July 2013
  • "Toxicology of baclofen continuously infused into the spinal intrathecal space of the dog" NeuroToxicology  1993
  • "Intrathecal ketorolac in dogs and rats" Toxicological Sciences August 2004
  • "Developmental changes in the sensitivity of the neonatal rat brain to hypoxic/ischemic injury" Brain Research August 8 1994
  • "Role of salt-induced kinase 1 in androgen neuroprotection against cerebral ischemia" Journal of Cerebral Blood Flow and Metabolism January 2011
  • "CASE OF THE MONTH" Brain Pathology July 1999
  • "Role of recurrent hypoxia-ischemia in preterm white matter injury severity" PLoS One November 12 2014

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